Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MMP7 (matrix metallopeptidase 7)

Identity

Alias_namesMPSL1
matrix metalloproteinase 7 (matrilysin
Alias_symbol (synonym)PUMP-1
Other aliasMMP-7
HGNC (Hugo) MMP7
LocusID (NCBI) 4316
Atlas_Id 53331
Location 11q22.2  [Link to chromosome band 11q22]
Location_base_pair Starts at 102520508 and ends at 102530753 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MMP7 (11q22.2) / MMP7 (11q22.2)TMEM123 (11q22.2) / MMP7 (11q22.2)TMEM123 11q22.2 / MMP7 11q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  TMEM123/MMP7 (11q22)

External links

Nomenclature
HGNC (Hugo)MMP7   7174
Cards
Entrez_Gene (NCBI)MMP7  4316  matrix metallopeptidase 7
AliasesMMP-7; MPSL1; PUMP-1
GeneCards (Weizmann)MMP7
Ensembl hg19 (Hinxton)ENSG00000137673 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137673 [Gene_View]  ENSG00000137673 [Sequence]  chr11:102520508-102530753 [Contig_View]  MMP7 [Vega]
ICGC DataPortalENSG00000137673
TCGA cBioPortalMMP7
AceView (NCBI)MMP7
Genatlas (Paris)MMP7
WikiGenes4316
SOURCE (Princeton)MMP7
Genetics Home Reference (NIH)MMP7
Genomic and cartography
GoldenPath hg38 (UCSC)MMP7  -     chr11:102520508-102530753 -  11q22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MMP7  -     11q22.2   [Description]    (hg19-Feb_2009)
EnsemblMMP7 - 11q22.2 [CytoView hg19]  MMP7 - 11q22.2 [CytoView hg38]
Mapping of homologs : NCBIMMP7 [Mapview hg19]  MMP7 [Mapview hg38]
OMIM178990   
Gene and transcription
Genbank (Entrez)AI675414 AK222980 AK293359 AK309687 BC003635
RefSeq transcript (Entrez)NM_002423
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MMP7
Cluster EST : UnigeneHs.2256 [ NCBI ]
CGAP (NCI)Hs.2256
Alternative Splicing GalleryENSG00000137673
Gene ExpressionMMP7 [ NCBI-GEO ]   MMP7 [ EBI - ARRAY_EXPRESS ]   MMP7 [ SEEK ]   MMP7 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4316
GTEX Portal (Tissue expression)MMP7
Human Protein AtlasENSG00000137673-MMP7 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09237   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09237  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09237
Splice isoforms : SwissVarP09237
Catalytic activity : Enzyme3.4.24.23 [ Enzyme-Expasy ]   3.4.24.233.4.24.23 [ IntEnz-EBI ]   3.4.24.23 [ BRENDA ]   3.4.24.23 [ KEGG ]   
PhosPhoSitePlusP09237
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)M10A_MMP    Matrilysin    MetalloPept_cat_dom_sf    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_Zn_BS    Peptidase_Metallo    Peptidoglycan-bd-like    PGBD-like_sf   
Domain families : Pfam (Sanger)Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00413    pfam01471   
Domain families : Smart (EMBL)ZnMc (SM00235)  
Conserved Domain (NCBI)MMP7
DMDM Disease mutations4316
Blocks (Seattle)MMP7
PDB (RSDB)1MMP    1MMQ    1MMR    2DDY    2MZE    2MZH    2MZI    2Y6C    2Y6D    5UE2    5UE5   
PDB Europe1MMP    1MMQ    1MMR    2DDY    2MZE    2MZH    2MZI    2Y6C    2Y6D    5UE2    5UE5   
PDB (PDBSum)1MMP    1MMQ    1MMR    2DDY    2MZE    2MZH    2MZI    2Y6C    2Y6D    5UE2    5UE5   
PDB (IMB)1MMP    1MMQ    1MMR    2DDY    2MZE    2MZH    2MZI    2Y6C    2Y6D    5UE2    5UE5   
Structural Biology KnowledgeBase1MMP    1MMQ    1MMR    2DDY    2MZE    2MZH    2MZI    2Y6C    2Y6D    5UE2    5UE5   
SCOP (Structural Classification of Proteins)1MMP    1MMQ    1MMR    2DDY    2MZE    2MZH    2MZI    2Y6C    2Y6D    5UE2    5UE5   
CATH (Classification of proteins structures)1MMP    1MMQ    1MMR    2DDY    2MZE    2MZH    2MZI    2Y6C    2Y6D    5UE2    5UE5   
SuperfamilyP09237
Human Protein Atlas [tissue]ENSG00000137673-MMP7 [tissue]
Peptide AtlasP09237
HPRD01525
IPIIPI00013400   
Protein Interaction databases
DIP (DOE-UCLA)P09237
IntAct (EBI)P09237
FunCoupENSG00000137673
BioGRIDMMP7
STRING (EMBL)MMP7
ZODIACMMP7
Ontologies - Pathways
QuickGOP09237
Ontology : AmiGOmetalloendopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  proteolysis  aging  heparin binding  metallopeptidase activity  zinc ion binding  cell surface  extracellular matrix disassembly  extracellular matrix organization  collagen catabolic process  collagen catabolic process  extracellular matrix  response to nutrient levels  estrous cycle  maternal process involved in female pregnancy  extracellular exosome  cellular response to mechanical stimulus  
Ontology : EGO-EBImetalloendopeptidase activity  metalloendopeptidase activity  serine-type endopeptidase activity  protein binding  extracellular region  extracellular space  proteolysis  aging  heparin binding  metallopeptidase activity  zinc ion binding  cell surface  extracellular matrix disassembly  extracellular matrix organization  collagen catabolic process  collagen catabolic process  extracellular matrix  response to nutrient levels  estrous cycle  maternal process involved in female pregnancy  extracellular exosome  cellular response to mechanical stimulus  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkMMP7
Atlas of Cancer Signalling NetworkMMP7
Wikipedia pathwaysMMP7
Orthology - Evolution
OrthoDB4316
GeneTree (enSembl)ENSG00000137673
Phylogenetic Trees/Animal Genes : TreeFamMMP7
HOGENOMP09237
Homologs : HomoloGeneMMP7
Homology/Alignments : Family Browser (UCSC)MMP7
Gene fusions - Rearrangements
Fusion : MitelmanTMEM123/MMP7 [11q22.2/11q22.2]  [t(11;11)(q22;q22)]  
Fusion PortalTMEM123 11q22.2 MMP7 11q22.2 OV
Fusion : QuiverMMP7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP7
dbVarMMP7
ClinVarMMP7
1000_GenomesMMP7 
Exome Variant ServerMMP7
ExAC (Exome Aggregation Consortium)ENSG00000137673
GNOMAD BrowserENSG00000137673
Varsome BrowserMMP7
Genetic variants : HAPMAP4316
Genomic Variants (DGV)MMP7 [DGVbeta]
DECIPHERMMP7 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMMP7 
Mutations
ICGC Data PortalMMP7 
TCGA Data PortalMMP7 
Broad Tumor PortalMMP7
OASIS PortalMMP7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP7
DgiDB (Drug Gene Interaction Database)MMP7
DoCM (Curated mutations)MMP7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP7 (select a term)
intoGenMMP7
Cancer3DMMP7(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM178990   
Orphanet
DisGeNETMMP7
MedgenMMP7
Genetic Testing Registry MMP7
NextProtP09237 [Medical]
TSGene4316
GENETestsMMP7
Target ValidationMMP7
Huge Navigator MMP7 [HugePedia]
snp3D : Map Gene to Disease4316
BioCentury BCIQMMP7
ClinGenMMP7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4316
Chemical/Pharm GKB GenePA30887
Clinical trialMMP7
Miscellaneous
canSAR (ICR)MMP7 (select the gene name)
DataMed IndexMMP7
Probes
Litterature
PubMed426 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP7
EVEXMMP7
GoPubMedMMP7
iHOPMMP7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:25:49 CET 2019
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