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MMP8 (matrix metallopeptidase 8)

Identity

Alias_namesCLG1
matrix metalloproteinase 8 (neutrophil collagenase)
HGNC (Hugo) MMP8
LocusID (NCBI) 4317
Atlas_Id 41407
Location 11q22.2  [Link to chromosome band 11q22]
Location_base_pair Starts at 102582526 and ends at 102595685 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MMP8   7175
Cards
Entrez_Gene (NCBI)MMP8  4317  matrix metallopeptidase 8
AliasesCLG1; HNC; MMP-8; PMNL-CL
GeneCards (Weizmann)MMP8
Ensembl hg19 (Hinxton)ENSG00000118113 [Gene_View]  chr11:102582526-102595685 [Contig_View]  MMP8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000118113 [Gene_View]  chr11:102582526-102595685 [Contig_View]  MMP8 [Vega]
ICGC DataPortalENSG00000118113
TCGA cBioPortalMMP8
AceView (NCBI)MMP8
Genatlas (Paris)MMP8
WikiGenes4317
SOURCE (Princeton)MMP8
Genetics Home Reference (NIH)MMP8
Genomic and cartography
GoldenPath hg19 (UCSC)MMP8  -     chr11:102582526-102595685 -  11q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MMP8  -     11q22.2   [Description]    (hg38-Dec_2013)
EnsemblMMP8 - 11q22.2 [CytoView hg19]  MMP8 - 11q22.2 [CytoView hg38]
Mapping of homologs : NCBIMMP8 [Mapview hg19]  MMP8 [Mapview hg38]
OMIM120355   
Gene and transcription
Genbank (Entrez)AK292659 AK303388 AK303511 AK313374 AL597614
RefSeq transcript (Entrez)NM_001304441 NM_001304442 NM_002424
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_012101 NT_033899 NW_004929381
Consensus coding sequences : CCDS (NCBI)MMP8
Cluster EST : UnigeneHs.161839 [ NCBI ]
CGAP (NCI)Hs.161839
Alternative Splicing GalleryENSG00000118113
Gene ExpressionMMP8 [ NCBI-GEO ]   MMP8 [ EBI - ARRAY_EXPRESS ]   MMP8 [ SEEK ]   MMP8 [ MEM ]
Gene Expression Viewer (FireBrowse)MMP8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4317
GTEX Portal (Tissue expression)MMP8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22894   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP22894  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP22894
Splice isoforms : SwissVarP22894
Catalytic activity : Enzyme3.4.24.34 [ Enzyme-Expasy ]   3.4.24.343.4.24.34 [ IntEnz-EBI ]   3.4.24.34 [ BRENDA ]   3.4.24.34 [ KEGG ]   
PhosPhoSitePlusP22894
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom    Hemopexin-like_repeat    Hemopexin_CS    MetalloPept_cat_dom    MMP8    Pept_M10_metallopeptidase    Pept_M10A    Pept_M10A_stromelysin-type    Pept_M10A_Zn_BS    Peptidase_Metallo    Peptidoglycan-bd-like   
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
Conserved Domain (NCBI)MMP8
DMDM Disease mutations4317
Blocks (Seattle)MMP8
PDB (SRS)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4    4QKZ   
PDB (PDBSum)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4    4QKZ   
PDB (IMB)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4    4QKZ   
PDB (RSDB)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4    4QKZ   
Structural Biology KnowledgeBase1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4    4QKZ   
SCOP (Structural Classification of Proteins)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4    4QKZ   
CATH (Classification of proteins structures)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4    4QKZ   
SuperfamilyP22894
Human Protein AtlasENSG00000118113
Peptide AtlasP22894
HPRD00385
IPIIPI00027846   IPI00910615   IPI01010335   IPI00979042   IPI00979828   IPI00978421   
Protein Interaction databases
DIP (DOE-UCLA)P22894
IntAct (EBI)P22894
FunCoupENSG00000118113
BioGRIDMMP8
STRING (EMBL)MMP8
ZODIACMMP8
Ontologies - Pathways
QuickGOP22894
Ontology : AmiGOmetalloendopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteinaceous extracellular matrix  extracellular space  proteolysis  zinc ion binding  extracellular matrix disassembly  collagen catabolic process  endodermal cell differentiation  
Ontology : EGO-EBImetalloendopeptidase activity  serine-type endopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteinaceous extracellular matrix  extracellular space  proteolysis  zinc ion binding  extracellular matrix disassembly  collagen catabolic process  endodermal cell differentiation  
NDEx NetworkMMP8
Atlas of Cancer Signalling NetworkMMP8
Wikipedia pathwaysMMP8
Orthology - Evolution
OrthoDB4317
GeneTree (enSembl)ENSG00000118113
Phylogenetic Trees/Animal Genes : TreeFamMMP8
HOVERGENP22894
HOGENOMP22894
Homologs : HomoloGeneMMP8
Homology/Alignments : Family Browser (UCSC)MMP8
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMMP8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MMP8
dbVarMMP8
ClinVarMMP8
1000_GenomesMMP8 
Exome Variant ServerMMP8
ExAC (Exome Aggregation Consortium)MMP8 (select the gene name)
Genetic variants : HAPMAP4317
Genomic Variants (DGV)MMP8 [DGVbeta]
DECIPHER (Syndromes)11:102582526-102595685  ENSG00000118113
CONAN: Copy Number AnalysisMMP8 
Mutations
ICGC Data PortalMMP8 
TCGA Data PortalMMP8 
Broad Tumor PortalMMP8
OASIS PortalMMP8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMMP8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMMP8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MMP8
DgiDB (Drug Gene Interaction Database)MMP8
DoCM (Curated mutations)MMP8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MMP8 (select a term)
intoGenMMP8
Cancer3DMMP8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM120355   
Orphanet
MedgenMMP8
Genetic Testing Registry MMP8
NextProtP22894 [Medical]
TSGene4317
GENETestsMMP8
Huge Navigator MMP8 [HugePedia]
snp3D : Map Gene to Disease4317
BioCentury BCIQMMP8
ClinGenMMP8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4317
Chemical/Pharm GKB GenePA30888
Clinical trialMMP8
Miscellaneous
canSAR (ICR)MMP8 (select the gene name)
Probes
Litterature
PubMed163 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMMP8
EVEXMMP8
GoPubMedMMP8
iHOPMMP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:44:44 CET 2016

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