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MMP8 (matrix metallopeptidase 8 (neutrophil collagenase))

Identity

Other namesCLG1
HNC
MMP-8
PMNL-CL
HGNC (Hugo) MMP8
LocusID (NCBI) 4317
Location 11q22.2
Location_base_pair Starts at 102582526 and ends at 102595685 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MMP8   7175
Cards
Entrez_Gene (NCBI)MMP8  4317  matrix metallopeptidase 8 (neutrophil collagenase)
GeneCards (Weizmann)MMP8
Ensembl (Hinxton)ENSG00000118113 [Gene_View]  chr11:102582526-102595685 [Contig_View]  MMP8 [Vega]
ICGC DataPortalENSG00000118113
cBioPortalMMP8
AceView (NCBI)MMP8
Genatlas (Paris)MMP8
WikiGenes4317
SOURCE (Princeton)NM_002424
Genomic and cartography
GoldenPath (UCSC)MMP8  -  11q22.2   chr11:102582526-102595685 -  11q22.2   [Description]    (hg19-Feb_2009)
EnsemblMMP8 - 11q22.2 [CytoView]
Mapping of homologs : NCBIMMP8 [Mapview]
OMIM120355   
Gene and transcription
Genbank (Entrez)AK292659 AK303388 AK303511 AK313374 BC074988
RefSeq transcript (Entrez)NM_002424
RefSeq genomic (Entrez)AC_000143 NC_000011 NC_018922 NG_012101 NT_033899 NW_001838042 NW_004929381
Consensus coding sequences : CCDS (NCBI)MMP8
Cluster EST : UnigeneHs.161839 [ NCBI ]
CGAP (NCI)Hs.161839
Alternative Splicing : Fast-db (Paris)GSHG0006126
Alternative Splicing GalleryENSG00000118113
Gene ExpressionMMP8 [ NCBI-GEO ]     MMP8 [ SEEK ]   MMP8 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP22894 (Uniprot)
NextProtP22894  [Medical]
With graphics : InterProP22894
Splice isoforms : SwissVarP22894 (Swissvar)
Catalytic activity : Enzyme3.4.24.34 [ Enzyme-Expasy ]   3.4.24.343.4.24.34 [ IntEnz-EBI ]   3.4.24.34 [ BRENDA ]   3.4.24.34 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CYSTEINE_SWITCH (PS00546)    HEMOPEXIN (PS00024)    HEMOPEXIN_2 (PS51642)    ZINC_PROTEASE (PS00142)   
Domains : Interpro (EBI)Hemopexin-like_dom [organisation]   Hemopexin-like_repeat [organisation]   Hemopexin_CS [organisation]   MetalloPept_cat_dom [organisation]   MMP8 [organisation]   Pept_M10_metallopeptidase [organisation]   Pept_M10A [organisation]   Pept_M10A_stromelysin-type [organisation]   Pept_M10A_Zn_BS [organisation]   Peptidase_Metallo [organisation]   Peptidoglycan-bd-like [organisation]  
Related proteins : CluSTrP22894
Domain families : Pfam (Sanger)Hemopexin (PF00045)    Peptidase_M10 (PF00413)    PG_binding_1 (PF01471)   
Domain families : Pfam (NCBI)pfam00045    pfam00413    pfam01471   
Domain families : Smart (EMBL)HX (SM00120)  ZnMc (SM00235)  
DMDM Disease mutations4317
Blocks (Seattle)P22894
PDB (SRS)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4   
PDB (PDBSum)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4   
PDB (IMB)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4   
PDB (RSDB)1A85    1A86    1BZS    1I73    1I76    1JAN    1JAO    1JAP    1JAQ    1JH1    1JJ9    1KBC    1MMB    1MNC    1ZP5    1ZS0    1ZVX    2OY2    2OY4    3DNG    3DPE    3DPF    3TT4   
Human Protein AtlasENSG00000118113 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP22894
HPRD00385
IPIIPI00027846   IPI00910615   IPI01010335   IPI00979042   IPI00979828   IPI00978421   
Protein Interaction databases
DIP (DOE-UCLA)P22894
IntAct (EBI)P22894
FunCoupENSG00000118113
BioGRIDMMP8
InParanoidP22894
Interologous Interaction database P22894
IntegromeDBMMP8
STRING (EMBL)MMP8
Ontologies - Pathways
Ontology : AmiGOmetalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteinaceous extracellular matrix  extracellular space  proteolysis  zinc ion binding  extracellular matrix disassembly  extracellular matrix organization  collagen catabolic process  
Ontology : EGO-EBImetalloendopeptidase activity  serine-type endopeptidase activity  calcium ion binding  extracellular region  proteinaceous extracellular matrix  extracellular space  proteolysis  zinc ion binding  extracellular matrix disassembly  extracellular matrix organization  collagen catabolic process  
Protein Interaction DatabaseMMP8
Wikipedia pathwaysMMP8
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MMP8
snp3D : Map Gene to Disease4317
SNP (GeneSNP Utah)MMP8
SNP : HGBaseMMP8
Genetic variants : HAPMAPMMP8
Exome VariantMMP8
1000_GenomesMMP8 
ICGC programENSG00000118113 
Somatic Mutations in Cancer : COSMICMMP8 
CONAN: Copy Number AnalysisMMP8 
Mutations and Diseases : HGMDMMP8
Mutations and Diseases : intOGenMMP8
Genomic VariantsMMP8  MMP8 [DGVbeta]
dbVarMMP8
ClinVarMMP8
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM120355   
MedgenMMP8
GENETestsMMP8
Disease Genetic AssociationMMP8
Huge Navigator MMP8 [HugePedia]  MMP8 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMMP8
Homology/Alignments : Family Browser (UCSC)MMP8
Phylogenetic Trees/Animal Genes : TreeFamMMP8
Chemical/Protein Interactions : CTD4317
Chemical/Pharm GKB GenePA30888
Clinical trialMMP8
Cancer Resource (Charite)ENSG00000118113
Other databases
Probes
Litterature
PubMed143 Pubmed reference(s) in Entrez
CoreMineMMP8
iHOPMMP8
OncoSearchMMP8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:56:23 CEST 2014

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