MMRN2 (multimerin 2)

2014-08-01  

Identity

HGNC
MMRN2
LOCATION
10q23.2
LOCUSID
79812
ALIAS
EMILIN-3,EMILIN3,ENDOGLYX-1

Other Information

Locus ID:

NCBI: 79812
MIM: 608925
HGNC: 19888
Ensembl: ENSG00000173269

Variants:

dbSNP: 79812
ClinVar: 79812
TCGA: ENSG00000173269
COSMIC: MMRN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173269ENST00000372027Q9H8L6
ENSG00000173269ENST00000474994R4GMY6
ENSG00000173269ENST00000608090V9GY37
ENSG00000173269ENST00000609457V9GY43
ENSG00000173269ENST00000610081V9GYS9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
239797072013SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers.25
257459972015Blocking CLEC14A-MMRN2 binding inhibits sprouting angiogenesis and tumour growth.19
284350162017The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis.16
286716702017Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.15
289120332017Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium.11
305449092018Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis.4

Citation

Dessen P

MMRN2 (multimerin 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54823/mmrn2