MMS22L (MMS22 like, DNA repair protein)

2010-11-01 Affiliation

Identity

HGNC

MMS22L

LOCATION

6q16.1

LOCUSID

253714

ALIAS

C6orf167,dJ39B17.2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 253714
MIM: 615614
HGNC: 21475
Ensembl: ENSG00000146263

Variants:

dbSNP: 253714
ClinVar: 253714
TCGA: ENSG00000146263
COSMIC: MMS22L

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000146263	ENST00000275053	Q6ZRQ5
ENSG00000146263	ENST00000369251	E2QRD4
ENSG00000146263	ENST00000482634	H0Y8J1
ENSG00000146263	ENST00000496119	H9KVD7
ENSG00000146263	ENST00000509383	H9KVD8
ENSG00000146263	ENST00000510018	H0YAJ2

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

References

Pubmed ID	Year	Title	Citations
21055985	2010	A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability.	48
21055983	2010	The MMS22L-TONSL complex mediates recovery from replication stress and homologous recombination.	47
27338793	2016	H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.	44
21055984	2010	Identification of the MMS22L-TONSL complex that promotes homologous recombination.	42
21113133	2010	RNAi-based screening identifies the Mms22L-Nfkbil2 complex as a novel regulator of DNA replication in human cells.	27
27797818	2016	The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress.	18
29478807	2018	The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.	11
22895565	2012	Identification of a novel oncogene, MMS22L, involved in lung and esophageal carcinogenesis.	0

Citation

Dessen P

MMS22L (MMS22 like, DNA repair protein)

Atlas Genet Cytogenet Oncol Haematol. 2010-11-01

Online version: http://atlasgeneticsoncology.org/gene/51746/mms22l