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MNAT1 (MNAT1 component of CDK activating kinase)

Identity

Alias (NCBI)CAP35
MAT1
RNF66
TFB3
HGNC (Hugo) MNAT1
HGNC Alias symbMAT1
RNF66
HGNC Alias nameCDK-activating kinase assembly factor
HGNC Previous namemenage a trois 1 (CAK assembly factor)
 menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)
 MNAT CDK-activating kinase assembly factor 1
 MNAT1, CDK activating kinase assembly factor
LocusID (NCBI) 4331
Atlas_Id 41411
Location 14q23.1  [Link to chromosome band 14q23]
Location_base_pair Starts at 60734761 and ends at 60969964 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CACNA1C (12p13.33) / MNAT1 (14q23.1)HIF1A (14q23.2) / MNAT1 (14q23.1)MNAT1 (14q23.1) / L2HGDH (14q21.3)
MNAT1 (14q23.1) / MNAT1 (14q23.1)MNAT1 (14q23.1) / PCNXL4 ()MNAT1 (14q23.1) / RASGEF1B (4q21.21)
MNAT1 (14q23.1) / SEPT2 (2q37.3)MNAT1 (14q23.1) / SIX1 (14q23.1)SVIL (10p11.23) / MNAT1 (14q23.1)
TANK (2q24.2) / MNAT1 (14q23.1)HIF1A 14q23.2 / MNAT1 14q23.1MNAT1 14q23.1 C14orf135
MNAT1 14q23.1 / RASGEF1B 4q21.21MNAT1 14q23.1 / SIX1 14q23.1TANK 2q24.2 / MNAT1 14q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MNAT1   7181
Cards
Entrez_Gene (NCBI)MNAT1    MNAT1 component of CDK activating kinase
AliasesCAP35; MAT1; RNF66; TFB3
GeneCards (Weizmann)MNAT1
Ensembl hg19 (Hinxton)ENSG00000020426 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000020426 [Gene_View]  ENSG00000020426 [Sequence]  chr14:60734761-60969964 [Contig_View]  MNAT1 [Vega]
ICGC DataPortalENSG00000020426
TCGA cBioPortalMNAT1
AceView (NCBI)MNAT1
Genatlas (Paris)MNAT1
SOURCE (Princeton)MNAT1
Genetics Home Reference (NIH)MNAT1
Genomic and cartography
GoldenPath hg38 (UCSC)MNAT1  -     chr14:60734761-60969964 +  14q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MNAT1  -     14q23.1   [Description]    (hg19-Feb_2009)
GoldenPathMNAT1 - 14q23.1 [CytoView hg19]  MNAT1 - 14q23.1 [CytoView hg38]
ImmunoBaseENSG00000020426
Genome Data Viewer NCBIMNAT1 [Mapview hg19]  
OMIM602659   
Gene and transcription
Genbank (Entrez)AA053721 AK308701 BC000820 BU620200 CD701743
RefSeq transcript (Entrez)NM_001177963 NM_002431
Consensus coding sequences : CCDS (NCBI)MNAT1
Gene ExpressionMNAT1 [ NCBI-GEO ]   MNAT1 [ EBI - ARRAY_EXPRESS ]   MNAT1 [ SEEK ]   MNAT1 [ MEM ]
Gene Expression Viewer (FireBrowse)MNAT1 [ Firebrowse - Broad ]
GenevisibleExpression of MNAT1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4331
GTEX Portal (Tissue expression)MNAT1
Human Protein AtlasENSG00000020426-MNAT1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP51948   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP51948  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP51948
PhosPhoSitePlusP51948
Domaine pattern : Prosite (Expaxy)UIM (PS50330)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Cdk-activating_kinase_MAT1_cen    MAT1/Tfb3    UIM_dom    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)MAT1 (PF06391)    zf-C3HC4_5 (PF17121)   
Domain families : Pfam (NCBI)pfam06391    pfam17121   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)MNAT1
PDB (RSDB)1G25    6NMI    6O9L    6O9M    6XBZ    6XD3   
PDB Europe1G25    6NMI    6O9L    6O9M    6XBZ    6XD3   
PDB (PDBSum)1G25    6NMI    6O9L    6O9M    6XBZ    6XD3   
PDB (IMB)1G25    6NMI    6O9L    6O9M    6XBZ    6XD3   
Structural Biology KnowledgeBase1G25    6NMI    6O9L    6O9M    6XBZ    6XD3   
SCOP (Structural Classification of Proteins)1G25    6NMI    6O9L    6O9M    6XBZ    6XD3   
CATH (Classification of proteins structures)1G25    6NMI    6O9L    6O9M    6XBZ    6XD3   
SuperfamilyP51948
AlphaFold pdb e-kbP51948   
Human Protein Atlas [tissue]ENSG00000020426-MNAT1 [tissue]
HPRD04042
Protein Interaction databases
DIP (DOE-UCLA)P51948
IntAct (EBI)P51948
BioGRIDMNAT1
STRING (EMBL)MNAT1
ZODIACMNAT1
Ontologies - Pathways
QuickGOP51948
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  transcription factor TFIIH core complex  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIIH holo complex  transcription factor TFIIH holo complex  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  adult heart development  zinc ion binding  cyclin-dependent protein kinase activating kinase holoenzyme complex  ventricular system development  negative regulation of apoptotic process  positive regulation of cyclin-dependent protein serine/threonine kinase activity  protein N-terminus binding  positive regulation of smooth muscle cell proliferation  response to calcium ion  cyclin-dependent protein serine/threonine kinase activator activity  protein-containing complex assembly  CAK-ERCC2 complex  transcription factor TFIIK complex  negative regulation of DNA helicase activity  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  G1/S transition of mitotic cell cycle  G2/M transition of mitotic cell cycle  transcription factor TFIIH core complex  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIIH holo complex  transcription factor TFIIH holo complex  DNA repair  transcription-coupled nucleotide-excision repair  nucleotide-excision repair, preincision complex assembly  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  transcription initiation from RNA polymerase I promoter  termination of RNA polymerase I transcription  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription by RNA polymerase II  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  adult heart development  zinc ion binding  cyclin-dependent protein kinase activating kinase holoenzyme complex  ventricular system development  negative regulation of apoptotic process  positive regulation of cyclin-dependent protein serine/threonine kinase activity  protein N-terminus binding  positive regulation of smooth muscle cell proliferation  response to calcium ion  cyclin-dependent protein serine/threonine kinase activator activity  protein-containing complex assembly  CAK-ERCC2 complex  transcription factor TFIIK complex  negative regulation of DNA helicase activity  
Pathways : BIOCARTASonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle [Genes]   
Pathways : KEGGBasal transcription factors    Nucleotide excision repair   
NDEx NetworkMNAT1
Atlas of Cancer Signalling NetworkMNAT1
Wikipedia pathwaysMNAT1
Orthology - Evolution
OrthoDB4331
GeneTree (enSembl)ENSG00000020426
Phylogenetic Trees/Animal Genes : TreeFamMNAT1
Homologs : HomoloGeneMNAT1
Homology/Alignments : Family Browser (UCSC)MNAT1
Gene fusions - Rearrangements
Fusion : MitelmanHIF1A/MNAT1 [14q23.2/14q23.1]  
Fusion : MitelmanMNAT1/PCNXL4 [14q23.1/14q23.1]  
Fusion : MitelmanMNAT1/RASGEF1B [14q23.1/4q21.21]  
Fusion : MitelmanMNAT1/SIX1 [14q23.1/14q23.1]  
Fusion : MitelmanTANK/MNAT1 [2q24.2/14q23.1]  
Fusion : QuiverMNAT1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMNAT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MNAT1
dbVarMNAT1
ClinVarMNAT1
MonarchMNAT1
1000_GenomesMNAT1 
Exome Variant ServerMNAT1
GNOMAD BrowserENSG00000020426
Varsome BrowserMNAT1
ACMGMNAT1 variants
VarityP51948
Genomic Variants (DGV)MNAT1 [DGVbeta]
DECIPHERMNAT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMNAT1 
Mutations
ICGC Data PortalMNAT1 
TCGA Data PortalMNAT1 
Broad Tumor PortalMNAT1
OASIS PortalMNAT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMNAT1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMNAT1
Mutations and Diseases : HGMDMNAT1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMNAT1
DgiDB (Drug Gene Interaction Database)MNAT1
DoCM (Curated mutations)MNAT1
CIViC (Clinical Interpretations of Variants in Cancer)MNAT1
Cancer3DMNAT1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602659   
Orphanet
DisGeNETMNAT1
MedgenMNAT1
Genetic Testing Registry MNAT1
NextProtP51948 [Medical]
GENETestsMNAT1
Target ValidationMNAT1
Huge Navigator MNAT1 [HugePedia]
ClinGenMNAT1
Clinical trials, drugs, therapy
MyCancerGenomeMNAT1
Protein Interactions : CTDMNAT1
Pharm GKB GenePA30894
PharosP51948
Clinical trialMNAT1
Miscellaneous
canSAR (ICR)MNAT1
HarmonizomeMNAT1
DataMed IndexMNAT1
Probes
Litterature
PubMed114 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMNAT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:21:06 CEST 2021

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