MOGAT2 (monoacylglycerol O-acyltransferase 2)

2014-11-01  

Identity

HGNC
LOCATION
11q13.5
LOCUSID
ALIAS
DGAT2L5,DGAT2L5.,MGAT2,hDC5
FUSION GENES

Other Information

Locus ID:

NCBI: 80168
MIM: 610270
HGNC: 23248
Ensembl: ENSG00000166391

Variants:

dbSNP: 80168
ClinVar: 80168
TCGA: ENSG00000166391
COSMIC: MOGAT2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166391ENST00000198801Q3SYC2
ENSG00000166391ENST00000525093Q3SYC2
ENSG00000166391ENST00000526712Q3SYC2

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerolipid metabolismKEGGhsa00561
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
126210632003MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine.50
125764792003Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2.41
247841382014Intestine-specific deletion of acyl-CoA:monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance.20
235366402013Intestine-specific expression of MOGAT2 partially restores metabolic efficiency in Mogat2-deficient mice.13
245736742014Monoacylglycerol acyltransferase-2 is a tetrameric enzyme that selectively heterodimerizes with diacylglycerol acyltransferase-1.8
275319672016Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome.3
255980792015Cell-based assay of MGAT2-driven diacylglycerol synthesis for profiling inhibitors: use of a stable isotope-labeled substrate and high-resolution LC/MS.1
276656772017Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo.0

Citation

Dessen P

MOGAT2 (monoacylglycerol O-acyltransferase 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70366/mogat2