MOGS (mannosyl-oligosaccharide glucosidase)

2014-11-01  

Identity

HGNC
MOGS
LOCATION
2p13.1
LOCUSID
7841
ALIAS
CDG2B,CWH41,DER7,GCS1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7841
MIM: 601336
HGNC: 24862
Ensembl: ENSG00000115275

Variants:

dbSNP: 7841
ClinVar: 7841
TCGA: ENSG00000115275
COSMIC: MOGS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115275ENST00000409065B8ZZE2
ENSG00000115275ENST00000414701C9JDQ1
ENSG00000115275ENST00000448666Q13724
ENSG00000115275ENST00000448666A0A384MDR6
ENSG00000115275ENST00000452063Q13724
ENSG00000115275ENST00000462443A0A3B3IRW2
ENSG00000115275ENST00000647723A0A3B3ITU6
ENSG00000115275ENST00000647753B4E3B8
ENSG00000115275ENST00000647771A0A3B3IRI1
ENSG00000115275ENST00000647915A0A3B3IU81
ENSG00000115275ENST00000648810A0A3B3IRW2
ENSG00000115275ENST00000649075A0A3B3ITC1
ENSG00000115275ENST00000649601A0A3B3IRI7
ENSG00000115275ENST00000649854A0A3B3IRK6
ENSG00000115275ENST00000650523A0A3B3IS52

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
N-Glycan biosynthesisKEGGko00510
N-Glycan biosynthesisKEGGhsa00510
Metabolic pathwaysKEGGhsa01100
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
N-glycan precursor trimmingKEGGhsa_M00073
N-glycan precursor trimmingKEGGM00073
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
N-glycan trimming in the ER and Calnexin/Calreticulin cycleREACTOMER-HSA-532668

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
247166612014Glycosylation, hypogammaglobulinemia, and resistance to viral infections.33
126264092003(Arg)3 within the N-terminal domain of glucosidase I contains ER targeting information but is not required absolutely for ER localization.8
119428562002Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells.7
124902812002Cloning MafF by recognition site screening with the NFE2 tandem repeat of HS2: analysis of its role in globin and GCSl genes regulation.4
305878462019Compound heterozygous variants in MOGS inducing congenital disorders of glycosylation (CDG) IIb.0

Citation

Dessen P

MOGS (mannosyl-oligosaccharide glucosidase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70367/mogs