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MORC3 (MORC family CW-type zinc finger 3)

Identity

Alias (NCBI)NXP2
ZCW5
ZCWCC3
HGNC (Hugo) MORC3
HGNC Alias symbZCW5
NXP2
KIAA0136
HGNC Previous nameZCWCC3
HGNC Previous namezinc finger, CW-type with coiled-coil domain 3
 zinc finger, CW type with coiled-coil domain 3
LocusID (NCBI) 23515
Atlas_Id 53782
Location 21q22.12  [Link to chromosome band 21q22]
Location_base_pair Starts at 36320197 and ends at 36376632 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASXL2 (2p23.3) / MORC3 (21q22.12)MORC3 (21q22.12) / DOPEY2 (21q22.12)MORC3 (21q22.12) / FAM3B (21q22.3)
MORC3 (21q22.12) / MORC3 (21q22.12)MORC3 (21q22.12) / PPP3R1 (2p14)NEDD4L (18q21.31) / MORC3 (21q22.12)
ASXL2 2p23.3 / MORC3 21q22.12MORC3 21q22.12 / DOPEY2 21q22.12MORC3 21q22.12 / FAM3B 21q22.3
NEDD4L 18q21.31 / MORC3 21q22.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MORC3   23572
Cards
Entrez_Gene (NCBI)MORC3    MORC family CW-type zinc finger 3
AliasesNXP2; ZCW5; ZCWCC3
GeneCards (Weizmann)MORC3
Ensembl hg19 (Hinxton)ENSG00000159256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159256 [Gene_View]  ENSG00000159256 [Sequence]  chr21:36320197-36376632 [Contig_View]  MORC3 [Vega]
ICGC DataPortalENSG00000159256
TCGA cBioPortalMORC3
AceView (NCBI)MORC3
Genatlas (Paris)MORC3
SOURCE (Princeton)MORC3
Genetics Home Reference (NIH)MORC3
Genomic and cartography
GoldenPath hg38 (UCSC)MORC3  -     chr21:36320197-36376632 +  21q22.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MORC3  -     21q22.12   [Description]    (hg19-Feb_2009)
GoldenPathMORC3 - 21q22.12 [CytoView hg19]  MORC3 - 21q22.12 [CytoView hg38]
ImmunoBaseENSG00000159256
Genome Data Viewer NCBIMORC3 [Mapview hg19]  
OMIM610078   
Gene and transcription
Genbank (Entrez)AK025327 AK125011 AK292957 AK295133 BC007311
RefSeq transcript (Entrez)NM_001320445 NM_001320446 NM_015358
Consensus coding sequences : CCDS (NCBI)MORC3
Gene ExpressionMORC3 [ NCBI-GEO ]   MORC3 [ EBI - ARRAY_EXPRESS ]   MORC3 [ SEEK ]   MORC3 [ MEM ]
Gene Expression Viewer (FireBrowse)MORC3 [ Firebrowse - Broad ]
GenevisibleExpression of MORC3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23515
GTEX Portal (Tissue expression)MORC3
Human Protein AtlasENSG00000159256-MORC3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14149   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14149  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14149
PhosPhoSitePlusQ14149
Domaine pattern : Prosite (Expaxy)ZF_CW (PS51050)   
Domains : Interpro (EBI)HATPase_C_sf    Morc_S5    Znf_CW   
Domain families : Pfam (Sanger)Morc6_S5 (PF17942)    zf-CW (PF07496)   
Domain families : Pfam (NCBI)pfam17942    pfam07496   
Conserved Domain (NCBI)MORC3
PDB (RSDB)4QQ4    5SVI    5SVX    5SVY    6O1E    6O5W   
PDB Europe4QQ4    5SVI    5SVX    5SVY    6O1E    6O5W   
PDB (PDBSum)4QQ4    5SVI    5SVX    5SVY    6O1E    6O5W   
PDB (IMB)4QQ4    5SVI    5SVX    5SVY    6O1E    6O5W   
Structural Biology KnowledgeBase4QQ4    5SVI    5SVX    5SVY    6O1E    6O5W   
SCOP (Structural Classification of Proteins)4QQ4    5SVI    5SVX    5SVY    6O1E    6O5W   
CATH (Classification of proteins structures)4QQ4    5SVI    5SVX    5SVY    6O1E    6O5W   
SuperfamilyQ14149
AlphaFold pdb e-kbQ14149   
Human Protein Atlas [tissue]ENSG00000159256-MORC3 [tissue]
HPRD10316
Protein Interaction databases
DIP (DOE-UCLA)Q14149
IntAct (EBI)Q14149
BioGRIDMORC3
STRING (EMBL)MORC3
ZODIACMORC3
Ontologies - Pathways
QuickGOQ14149
Ontology : AmiGORNA binding  protein binding  nucleoplasm  protein phosphorylation  cell aging  zinc ion binding  post-embryonic development  nuclear matrix  PML body  peptidyl-serine phosphorylation  methylated histone binding  negative regulation of fibroblast proliferation  protein stabilization  maintenance of protein location in nucleus  maintenance of protein location in nucleus  
Ontology : EGO-EBIRNA binding  protein binding  nucleoplasm  protein phosphorylation  cell aging  zinc ion binding  post-embryonic development  nuclear matrix  PML body  peptidyl-serine phosphorylation  methylated histone binding  negative regulation of fibroblast proliferation  protein stabilization  maintenance of protein location in nucleus  maintenance of protein location in nucleus  
NDEx NetworkMORC3
Atlas of Cancer Signalling NetworkMORC3
Wikipedia pathwaysMORC3
Orthology - Evolution
OrthoDB23515
GeneTree (enSembl)ENSG00000159256
Phylogenetic Trees/Animal Genes : TreeFamMORC3
Homologs : HomoloGeneMORC3
Homology/Alignments : Family Browser (UCSC)MORC3
Gene fusions - Rearrangements
Fusion : MitelmanASXL2/MORC3 [2p23.3/21q22.12]  
Fusion : MitelmanMORC3/DOPEY2 [21q22.12/21q22.12]  
Fusion : MitelmanMORC3/FAM3B [21q22.12/21q22.3]  
Fusion : MitelmanNEDD4L/MORC3 [18q21.31/21q22.12]  
Fusion : QuiverMORC3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMORC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MORC3
dbVarMORC3
ClinVarMORC3
MonarchMORC3
1000_GenomesMORC3 
Exome Variant ServerMORC3
GNOMAD BrowserENSG00000159256
Varsome BrowserMORC3
ACMGMORC3 variants
VarityQ14149
Genomic Variants (DGV)MORC3 [DGVbeta]
DECIPHERMORC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMORC3 
Mutations
ICGC Data PortalMORC3 
TCGA Data PortalMORC3 
Broad Tumor PortalMORC3
OASIS PortalMORC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMORC3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMORC3
Mutations and Diseases : HGMDMORC3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMORC3
DgiDB (Drug Gene Interaction Database)MORC3
DoCM (Curated mutations)MORC3
CIViC (Clinical Interpretations of Variants in Cancer)MORC3
Cancer3DMORC3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610078   
Orphanet
DisGeNETMORC3
MedgenMORC3
Genetic Testing Registry MORC3
NextProtQ14149 [Medical]
GENETestsMORC3
Target ValidationMORC3
Huge Navigator MORC3 [HugePedia]
ClinGenMORC3
Clinical trials, drugs, therapy
MyCancerGenomeMORC3
Protein Interactions : CTDMORC3
Pharm GKB GenePA128394632
PharosQ14149
Clinical trialMORC3
Miscellaneous
canSAR (ICR)MORC3
HarmonizomeMORC3
DataMed IndexMORC3
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMORC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:21:08 CEST 2021

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