MORC3 (MORC family CW-type zinc finger 3)

2014-01-01  

Identity

HGNC
MORC3
LOCATION
21q22.12
LOCUSID
23515
ALIAS
NXP2,ZCW5,ZCWCC3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23515
MIM: 610078
HGNC: 23572
Ensembl: ENSG00000159256

Variants:

dbSNP: 23515
ClinVar: 23515
TCGA: ENSG00000159256
COSMIC: MORC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159256ENST00000400485Q14149
ENSG00000159256ENST00000546482H0YHQ4
ENSG00000159256ENST00000549948H0YHQ4
ENSG00000159256ENST00000551788H0YHQ4
ENSG00000159256ENST00000552581H0YIR5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
240378942013Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ.64
165676192006NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.52
222584832012Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy.37
225465002012Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis.28
173325042007Dynamic regulation of p53 subnuclear localization and senescence by MORC3.27
205016962010Two-step colocalization of MORC3 with PML nuclear bodies.22
119275932002The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains.21
276536852016Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.13
262022332015The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication.9
281294902017Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients.9

Citation

Dessen P

MORC3 (MORC family CW-type zinc finger 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-01-01

Online version: http://atlasgeneticsoncology.org/gene/53782/morc3