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MORC3 (MORC family CW-type zinc finger 3)

Identity

Alias_namesZCWCC3
zinc finger, CW-type with coiled-coil domain 3
zinc finger, CW type with coiled-coil domain 3
Alias_symbol (synonym)ZCW5
NXP2
KIAA0136
Other alias
HGNC (Hugo) MORC3
LocusID (NCBI) 23515
Atlas_Id 53782
Location 21q22.12  [Link to chromosome band 21q22]
Location_base_pair Starts at 36320189 and ends at 36376646 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASXL2 (2p23.3) / MORC3 (21q22.12)MORC3 (21q22.12) / DOPEY2 (21q22.12)MORC3 (21q22.12) / FAM3B (21q22.3)
MORC3 (21q22.12) / MORC3 (21q22.12)MORC3 (21q22.12) / PPP3R1 (2p14)NEDD4L (18q21.31) / MORC3 (21q22.12)
ASXL2 2p23.3 / MORC3 21q22.12MORC3 21q22.12 / DOPEY2 21q22.12MORC3 21q22.12 / FAM3B 21q22.3
NEDD4L 18q21.31 / MORC3 21q22.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MORC3   23572
Cards
Entrez_Gene (NCBI)MORC3  23515  MORC family CW-type zinc finger 3
AliasesNXP2; ZCW5; ZCWCC3
GeneCards (Weizmann)MORC3
Ensembl hg19 (Hinxton)ENSG00000159256 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000159256 [Gene_View]  chr21:36320189-36376646 [Contig_View]  MORC3 [Vega]
ICGC DataPortalENSG00000159256
TCGA cBioPortalMORC3
AceView (NCBI)MORC3
Genatlas (Paris)MORC3
WikiGenes23515
SOURCE (Princeton)MORC3
Genetics Home Reference (NIH)MORC3
Genomic and cartography
GoldenPath hg38 (UCSC)MORC3  -     chr21:36320189-36376646 +  21q22.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MORC3  -     21q22.12   [Description]    (hg19-Feb_2009)
EnsemblMORC3 - 21q22.12 [CytoView hg19]  MORC3 - 21q22.12 [CytoView hg38]
Mapping of homologs : NCBIMORC3 [Mapview hg19]  MORC3 [Mapview hg38]
OMIM610078   
Gene and transcription
Genbank (Entrez)AK025327 AK125011 AK292957 AK295133 BC007311
RefSeq transcript (Entrez)NM_001320445 NM_001320446 NM_015358
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MORC3
Cluster EST : UnigeneHs.421150 [ NCBI ]
CGAP (NCI)Hs.421150
Alternative Splicing GalleryENSG00000159256
Gene ExpressionMORC3 [ NCBI-GEO ]   MORC3 [ EBI - ARRAY_EXPRESS ]   MORC3 [ SEEK ]   MORC3 [ MEM ]
Gene Expression Viewer (FireBrowse)MORC3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23515
GTEX Portal (Tissue expression)MORC3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14149   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14149  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14149
Splice isoforms : SwissVarQ14149
PhosPhoSitePlusQ14149
Domaine pattern : Prosite (Expaxy)ZF_CW (PS51050)   
Domains : Interpro (EBI)HATPase_C    Znf_CW   
Domain families : Pfam (Sanger)zf-CW (PF07496)   
Domain families : Pfam (NCBI)pfam07496   
Conserved Domain (NCBI)MORC3
DMDM Disease mutations23515
Blocks (Seattle)MORC3
PDB (SRS)4QQ4    5SVI    5SVX    5SVY   
PDB (PDBSum)4QQ4    5SVI    5SVX    5SVY   
PDB (IMB)4QQ4    5SVI    5SVX    5SVY   
PDB (RSDB)4QQ4    5SVI    5SVX    5SVY   
Structural Biology KnowledgeBase4QQ4    5SVI    5SVX    5SVY   
SCOP (Structural Classification of Proteins)4QQ4    5SVI    5SVX    5SVY   
CATH (Classification of proteins structures)4QQ4    5SVI    5SVX    5SVY   
SuperfamilyQ14149
Human Protein AtlasENSG00000159256
Peptide AtlasQ14149
HPRD10316
IPIIPI00436705   IPI01022300   IPI01022562   IPI00984459   
Protein Interaction databases
DIP (DOE-UCLA)Q14149
IntAct (EBI)Q14149
FunCoupENSG00000159256
BioGRIDMORC3
STRING (EMBL)MORC3
ZODIACMORC3
Ontologies - Pathways
QuickGOQ14149
Ontology : AmiGORNA binding  nucleoplasm  protein phosphorylation  cell aging  zinc ion binding  post-embryonic development  viral process  nuclear matrix  PML body  peptidyl-serine phosphorylation  negative regulation of fibroblast proliferation  protein stabilization  maintenance of protein location in nucleus  maintenance of protein location in nucleus  
Ontology : EGO-EBIRNA binding  nucleoplasm  protein phosphorylation  cell aging  zinc ion binding  post-embryonic development  viral process  nuclear matrix  PML body  peptidyl-serine phosphorylation  negative regulation of fibroblast proliferation  protein stabilization  maintenance of protein location in nucleus  maintenance of protein location in nucleus  
NDEx NetworkMORC3
Atlas of Cancer Signalling NetworkMORC3
Wikipedia pathwaysMORC3
Orthology - Evolution
OrthoDB23515
GeneTree (enSembl)ENSG00000159256
Phylogenetic Trees/Animal Genes : TreeFamMORC3
HOVERGENQ14149
HOGENOMQ14149
Homologs : HomoloGeneMORC3
Homology/Alignments : Family Browser (UCSC)MORC3
Gene fusions - Rearrangements
Fusion : MitelmanASXL2/MORC3 [2p23.3/21q22.12]  [t(2;21)(p23;q22)]  
Fusion : MitelmanMORC3/DOPEY2 [21q22.12/21q22.12]  [t(21;21)(q22;q22)]  
Fusion : MitelmanMORC3/FAM3B [21q22.12/21q22.3]  [t(21;21)(q22;q22)]  
Fusion : MitelmanNEDD4L/MORC3 [18q21.31/21q22.12]  [t(18;21)(q21;q22)]  
Fusion: TCGAASXL2 2p23.3 MORC3 21q22.12 PRAD
Fusion: TCGAMORC3 21q22.12 DOPEY2 21q22.12 BLCA
Fusion: TCGAMORC3 21q22.12 FAM3B 21q22.3 LUSC
Fusion: TCGANEDD4L 18q21.31 MORC3 21q22.12 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMORC3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MORC3
dbVarMORC3
ClinVarMORC3
1000_GenomesMORC3 
Exome Variant ServerMORC3
ExAC (Exome Aggregation Consortium)MORC3 (select the gene name)
Genetic variants : HAPMAP23515
Genomic Variants (DGV)MORC3 [DGVbeta]
DECIPHERMORC3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMORC3 
Mutations
ICGC Data PortalMORC3 
TCGA Data PortalMORC3 
Broad Tumor PortalMORC3
OASIS PortalMORC3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMORC3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMORC3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MORC3
DgiDB (Drug Gene Interaction Database)MORC3
DoCM (Curated mutations)MORC3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MORC3 (select a term)
intoGenMORC3
Cancer3DMORC3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610078   
Orphanet
MedgenMORC3
Genetic Testing Registry MORC3
NextProtQ14149 [Medical]
TSGene23515
GENETestsMORC3
Target ValidationMORC3
Huge Navigator MORC3 [HugePedia]
snp3D : Map Gene to Disease23515
BioCentury BCIQMORC3
ClinGenMORC3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23515
Chemical/Pharm GKB GenePA128394632
Clinical trialMORC3
Miscellaneous
canSAR (ICR)MORC3 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMORC3
EVEXMORC3
GoPubMedMORC3
iHOPMORC3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:20:26 CEST 2017

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