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MOS (MOS proto-oncogene, serine/threonine kinase)

Identity

Other aliasMSV
HGNC (Hugo) MOS
LocusID (NCBI) 4342
Atlas_Id 41414
Location 8q12.1  [Link to chromosome band 8q12]
Location_base_pair Starts at 56112942 and ends at 56113982 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  r(8)


External links

Nomenclature
HGNC (Hugo)MOS   7199
Cards
Entrez_Gene (NCBI)MOS  4342  MOS proto-oncogene, serine/threonine kinase
AliasesMSV
GeneCards (Weizmann)MOS
Ensembl hg19 (Hinxton)ENSG00000172680 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172680 [Gene_View]  chr8:56112942-56113982 [Contig_View]  MOS [Vega]
ICGC DataPortalENSG00000172680
TCGA cBioPortalMOS
AceView (NCBI)MOS
Genatlas (Paris)MOS
WikiGenes4342
SOURCE (Princeton)MOS
Genetics Home Reference (NIH)MOS
Genomic and cartography
GoldenPath hg38 (UCSC)MOS  -     chr8:56112942-56113982 -  8q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MOS  -     8q12.1   [Description]    (hg19-Feb_2009)
EnsemblMOS - 8q12.1 [CytoView hg19]  MOS - 8q12.1 [CytoView hg38]
Mapping of homologs : NCBIMOS [Mapview hg19]  MOS [Mapview hg38]
OMIM190060   
Gene and transcription
Genbank (Entrez)BC069569 BC069590 BC106737 BC106738 HQ447500
RefSeq transcript (Entrez)NM_005372
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MOS
Cluster EST : UnigeneHs.533432 [ NCBI ]
CGAP (NCI)Hs.533432
Alternative Splicing GalleryENSG00000172680
Gene ExpressionMOS [ NCBI-GEO ]   MOS [ EBI - ARRAY_EXPRESS ]   MOS [ SEEK ]   MOS [ MEM ]
Gene Expression Viewer (FireBrowse)MOS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4342
GTEX Portal (Tissue expression)MOS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00540   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00540  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00540
Splice isoforms : SwissVarP00540
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusP00540
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MOS
DMDM Disease mutations4342
Blocks (Seattle)MOS
SuperfamilyP00540
Human Protein AtlasENSG00000172680
Peptide AtlasP00540
HPRD01816
IPIIPI00018290   
Protein Interaction databases
DIP (DOE-UCLA)P00540
IntAct (EBI)P00540
FunCoupENSG00000172680
BioGRIDMOS
STRING (EMBL)MOS
ZODIACMOS
Ontologies - Pathways
QuickGOP00540
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  activation of MAPK activity  meiotic spindle organization  protein serine/threonine kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  signal transducer activity  protein binding  ATP binding  cytoplasm  chromatin organization  protein phosphorylation  intracellular signal transduction  positive regulation of MAPK cascade  protein autophosphorylation  establishment of meiotic spindle orientation  negative regulation of metaphase/anaphase transition of meiotic cell cycle  negative regulation of metaphase/anaphase transition of meiotic cell cycle  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  activation of MAPK activity  meiotic spindle organization  protein serine/threonine kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  signal transducer activity  protein binding  ATP binding  cytoplasm  chromatin organization  protein phosphorylation  intracellular signal transduction  positive regulation of MAPK cascade  protein autophosphorylation  establishment of meiotic spindle orientation  negative regulation of metaphase/anaphase transition of meiotic cell cycle  negative regulation of metaphase/anaphase transition of meiotic cell cycle  
Pathways : KEGGMAPK signaling pathway    Oocyte meiosis    Regulation of actin cytoskeleton    Progesterone-mediated oocyte maturation   
NDEx NetworkMOS
Atlas of Cancer Signalling NetworkMOS
Wikipedia pathwaysMOS
Orthology - Evolution
OrthoDB4342
GeneTree (enSembl)ENSG00000172680
Phylogenetic Trees/Animal Genes : TreeFamMOS
HOVERGENP00540
HOGENOMP00540
Homologs : HomoloGeneMOS
Homology/Alignments : Family Browser (UCSC)MOS
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMOS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MOS
dbVarMOS
ClinVarMOS
1000_GenomesMOS 
Exome Variant ServerMOS
ExAC (Exome Aggregation Consortium)MOS (select the gene name)
Genetic variants : HAPMAP4342
Genomic Variants (DGV)MOS [DGVbeta]
DECIPHERMOS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMOS 
Mutations
ICGC Data PortalMOS 
TCGA Data PortalMOS 
Broad Tumor PortalMOS
OASIS PortalMOS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMOS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMOS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MOS
DgiDB (Drug Gene Interaction Database)MOS
DoCM (Curated mutations)MOS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MOS (select a term)
intoGenMOS
Cancer3DMOS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190060   
Orphanet
MedgenMOS
Genetic Testing Registry MOS
NextProtP00540 [Medical]
TSGene4342
GENETestsMOS
Target ValidationMOS
Huge Navigator MOS [HugePedia]
snp3D : Map Gene to Disease4342
BioCentury BCIQMOS
ClinGenMOS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4342
Chemical/Pharm GKB GenePA30907
Clinical trialMOS
Miscellaneous
canSAR (ICR)MOS (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMOS
EVEXMOS
GoPubMedMOS
iHOPMOS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:08:08 CEST 2017

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