Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MPC2 (mitochondrial pyruvate carrier 2)

Identity

Alias (NCBI)BRP44
SLC54A2
HGNC (Hugo) MPC2
HGNC Alias symbDKFZP564B167
SLC54A2
HGNC Previous nameBRP44
HGNC Previous namebrain protein 44
LocusID (NCBI) 25874
Atlas_Id 55100
Location 1q24.2  [Link to chromosome band 1q24]
Location_base_pair Starts at 167916675 and ends at 167937069 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BLZF1 (1q24.2) / MPC2 (1q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  BLZF1/MPC2 (1q24)


External links

Nomenclature
HGNC (Hugo)MPC2   24515
Cards
Entrez_Gene (NCBI)MPC2  25874  mitochondrial pyruvate carrier 2
AliasesBRP44; SLC54A2
GeneCards (Weizmann)MPC2
Ensembl hg19 (Hinxton)ENSG00000143158 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143158 [Gene_View]  ENSG00000143158 [Sequence]  chr1:167916675-167937069 [Contig_View]  MPC2 [Vega]
ICGC DataPortalENSG00000143158
TCGA cBioPortalMPC2
AceView (NCBI)MPC2
Genatlas (Paris)MPC2
WikiGenes25874
SOURCE (Princeton)MPC2
Genetics Home Reference (NIH)MPC2
Genomic and cartography
GoldenPath hg38 (UCSC)MPC2  -     chr1:167916675-167937069 -  1q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPC2  -     1q24.2   [Description]    (hg19-Feb_2009)
GoldenPathMPC2 - 1q24.2 [CytoView hg19]  MPC2 - 1q24.2 [CytoView hg38]
ImmunoBaseENSG00000143158
genome Data Viewer NCBIMPC2 [Mapview hg19]  
OMIM614737   
Gene and transcription
Genbank (Entrez)AK290126 AK307189 AK311913 AL035304 AL110297
RefSeq transcript (Entrez)NM_001143674 NM_015415
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPC2
Alternative Splicing GalleryENSG00000143158
Gene ExpressionMPC2 [ NCBI-GEO ]   MPC2 [ EBI - ARRAY_EXPRESS ]   MPC2 [ SEEK ]   MPC2 [ MEM ]
Gene Expression Viewer (FireBrowse)MPC2 [ Firebrowse - Broad ]
GenevisibleExpression of MPC2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)25874
GTEX Portal (Tissue expression)MPC2
Human Protein AtlasENSG00000143158-MPC2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95563   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95563  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95563
Splice isoforms : SwissVarO95563
PhosPhoSitePlusO95563
Domains : Interpro (EBI)MPC   
Domain families : Pfam (Sanger)MPC (PF03650)   
Domain families : Pfam (NCBI)pfam03650   
Conserved Domain (NCBI)MPC2
DMDM Disease mutations25874
Blocks (Seattle)MPC2
SuperfamilyO95563
Human Protein Atlas [tissue]ENSG00000143158-MPC2 [tissue]
Peptide AtlasO95563
HPRD08525
IPIIPI00022832   IPI00640179   
Protein Interaction databases
DIP (DOE-UCLA)O95563
IntAct (EBI)O95563
FunCoupENSG00000143158
BioGRIDMPC2
STRING (EMBL)MPC2
ZODIACMPC2
Ontologies - Pathways
QuickGOO95563
Ontology : AmiGOnucleus  mitochondrion  mitochondrial pyruvate transmembrane transport  integral component of mitochondrial inner membrane  positive regulation of insulin secretion involved in cellular response to glucose stimulus  pyruvate transmembrane transporter activity  mitochondrial acetyl-CoA biosynthetic process from pyruvate  
Ontology : EGO-EBInucleus  mitochondrion  mitochondrial pyruvate transmembrane transport  integral component of mitochondrial inner membrane  positive regulation of insulin secretion involved in cellular response to glucose stimulus  pyruvate transmembrane transporter activity  mitochondrial acetyl-CoA biosynthetic process from pyruvate  
NDEx NetworkMPC2
Atlas of Cancer Signalling NetworkMPC2
Wikipedia pathwaysMPC2
Orthology - Evolution
OrthoDB25874
GeneTree (enSembl)ENSG00000143158
Phylogenetic Trees/Animal Genes : TreeFamMPC2
HOGENOMO95563
Homologs : HomoloGeneMPC2
Homology/Alignments : Family Browser (UCSC)MPC2
Gene fusions - Rearrangements
Fusion : MitelmanBLZF1/MPC2 [1q24.2/1q24.2]  
Fusion : QuiverMPC2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPC2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPC2
dbVarMPC2
ClinVarMPC2
MonarchMPC2
1000_GenomesMPC2 
Exome Variant ServerMPC2
GNOMAD BrowserENSG00000143158
Varsome BrowserMPC2
Genetic variants : HAPMAP25874
Genomic Variants (DGV)MPC2 [DGVbeta]
DECIPHERMPC2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMPC2 
Mutations
ICGC Data PortalMPC2 
TCGA Data PortalMPC2 
Broad Tumor PortalMPC2
OASIS PortalMPC2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMPC2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMPC2
Mutations and Diseases : HGMDMPC2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MPC2
DgiDB (Drug Gene Interaction Database)MPC2
DoCM (Curated mutations)MPC2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPC2 (select a term)
intoGenMPC2
Cancer3DMPC2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614737   
Orphanet
DisGeNETMPC2
MedgenMPC2
Genetic Testing Registry MPC2
NextProtO95563 [Medical]
TSGene25874
GENETestsMPC2
Target ValidationMPC2
Huge Navigator MPC2 [HugePedia]
snp3D : Map Gene to Disease25874
BioCentury BCIQMPC2
ClinGenMPC2
Clinical trials, drugs, therapy
Protein Interactions : CTD25874
Pharm GKB GenePA142672547
Clinical trialMPC2
Miscellaneous
canSAR (ICR)MPC2 (select the gene name)
HarmonizomeMPC2
DataMed IndexMPC2
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPC2
EVEXMPC2
GoPubMedMPC2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:22:43 CEST 2020

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