Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MPDZ (multiple PDZ domain crumbs cell polarity complex component)

Identity

Alias_namesmultiple PDZ domain protein
Alias_symbol (synonym)MUPP1
Other aliasHYC2
HGNC (Hugo) MPDZ
LocusID (NCBI) 8777
Atlas_Id 70388
Location 9p23  [Link to chromosome band 9p23]
Location_base_pair Starts at 13105704 and ends at 13279564 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MPDZ (9p23) / LURAP1L (9p23)MPDZ (9p23) / MPDZ (9p23)MPDZ (9p23) / NFIB (9p23)
MPDZ (9p23) / PLIN2 (9p22.1)MPDZ NFIBMPDZ C9orf150
MPDZ PLIN2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MPDZ   7208
Cards
Entrez_Gene (NCBI)MPDZ  8777  multiple PDZ domain crumbs cell polarity complex component
AliasesHYC2; MUPP1
GeneCards (Weizmann)MPDZ
Ensembl hg19 (Hinxton)ENSG00000107186 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107186 [Gene_View]  chr9:13105704-13279564 [Contig_View]  MPDZ [Vega]
ICGC DataPortalENSG00000107186
TCGA cBioPortalMPDZ
AceView (NCBI)MPDZ
Genatlas (Paris)MPDZ
WikiGenes8777
SOURCE (Princeton)MPDZ
Genetics Home Reference (NIH)MPDZ
Genomic and cartography
GoldenPath hg38 (UCSC)MPDZ  -     chr9:13105704-13279564 -  9p23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPDZ  -     9p23   [Description]    (hg19-Feb_2009)
EnsemblMPDZ - 9p23 [CytoView hg19]  MPDZ - 9p23 [CytoView hg38]
Mapping of homologs : NCBIMPDZ [Mapview hg19]  MPDZ [Mapview hg38]
OMIM603785   615219   
Gene and transcription
Genbank (Entrez)AA922649 AB210041 AF093419 AJ001319 AK058011
RefSeq transcript (Entrez)NM_001261406 NM_001261407 NM_001330637 NM_003829
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPDZ
Cluster EST : UnigeneHs.169378 [ NCBI ]
CGAP (NCI)Hs.169378
Alternative Splicing GalleryENSG00000107186
Gene ExpressionMPDZ [ NCBI-GEO ]   MPDZ [ EBI - ARRAY_EXPRESS ]   MPDZ [ SEEK ]   MPDZ [ MEM ]
Gene Expression Viewer (FireBrowse)MPDZ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8777
GTEX Portal (Tissue expression)MPDZ
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75970   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75970  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75970
Splice isoforms : SwissVarO75970
PhosPhoSitePlusO75970
Domaine pattern : Prosite (Expaxy)L27 (PS51022)    PDZ (PS50106)   
Domains : Interpro (EBI)L27_2    L27_dom    MPDZ    PDZ   
Domain families : Pfam (Sanger)L27_2 (PF09045)    MPDZ_u10 (PF16667)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam09045    pfam16667    pfam00595   
Domain families : Smart (EMBL)PDZ (SM00228)  
Conserved Domain (NCBI)MPDZ
DMDM Disease mutations8777
Blocks (Seattle)MPDZ
PDB (SRS)2FCF    2FNE    2IWN    2IWO    2IWP    2IWQ    2O2T    2OPG    2QG1   
PDB (PDBSum)2FCF    2FNE    2IWN    2IWO    2IWP    2IWQ    2O2T    2OPG    2QG1   
PDB (IMB)2FCF    2FNE    2IWN    2IWO    2IWP    2IWQ    2O2T    2OPG    2QG1   
PDB (RSDB)2FCF    2FNE    2IWN    2IWO    2IWP    2IWQ    2O2T    2OPG    2QG1   
Structural Biology KnowledgeBase2FCF    2FNE    2IWN    2IWO    2IWP    2IWQ    2O2T    2OPG    2QG1   
SCOP (Structural Classification of Proteins)2FCF    2FNE    2IWN    2IWO    2IWP    2IWQ    2O2T    2OPG    2QG1   
CATH (Classification of proteins structures)2FCF    2FNE    2IWN    2IWO    2IWP    2IWQ    2O2T    2OPG    2QG1   
SuperfamilyO75970
Human Protein AtlasENSG00000107186
Peptide AtlasO75970
HPRD09155
IPIIPI00552988   IPI00553004   IPI00642788   IPI00979039   IPI00973514   IPI01014375   IPI00015980   IPI01015308   IPI01010558   IPI00644904   IPI01014890   IPI00643880   IPI01012025   IPI01012548   
Protein Interaction databases
DIP (DOE-UCLA)O75970
IntAct (EBI)O75970
FunCoupENSG00000107186
BioGRIDMPDZ
STRING (EMBL)MPDZ
ZODIACMPDZ
Ontologies - Pathways
QuickGOO75970
Ontology : AmiGOprotein binding  cytoplasm  bicellular tight junction  cell adhesion  protein C-terminus binding  postsynaptic density  viral process  apical plasma membrane  apicolateral plasma membrane  dendrite  cytoplasmic vesicle  Schmidt-Lanterman incisure  postsynaptic membrane  
Ontology : EGO-EBIprotein binding  cytoplasm  bicellular tight junction  cell adhesion  protein C-terminus binding  postsynaptic density  viral process  apical plasma membrane  apicolateral plasma membrane  dendrite  cytoplasmic vesicle  Schmidt-Lanterman incisure  postsynaptic membrane  
Pathways : KEGGTight junction   
NDEx NetworkMPDZ
Atlas of Cancer Signalling NetworkMPDZ
Wikipedia pathwaysMPDZ
Orthology - Evolution
OrthoDB8777
GeneTree (enSembl)ENSG00000107186
Phylogenetic Trees/Animal Genes : TreeFamMPDZ
HOVERGENO75970
HOGENOMO75970
Homologs : HomoloGeneMPDZ
Homology/Alignments : Family Browser (UCSC)MPDZ
Gene fusions - Rearrangements
Fusion: TCGAMPDZ NFIB
Fusion: TCGAMPDZ C9orf150
Fusion: TCGAMPDZ PLIN2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPDZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPDZ
dbVarMPDZ
ClinVarMPDZ
1000_GenomesMPDZ 
Exome Variant ServerMPDZ
ExAC (Exome Aggregation Consortium)MPDZ (select the gene name)
Genetic variants : HAPMAP8777
Genomic Variants (DGV)MPDZ [DGVbeta]
DECIPHERMPDZ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMPDZ 
Mutations
ICGC Data PortalMPDZ 
TCGA Data PortalMPDZ 
Broad Tumor PortalMPDZ
OASIS PortalMPDZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMPDZ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMPDZ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MPDZ
DgiDB (Drug Gene Interaction Database)MPDZ
DoCM (Curated mutations)MPDZ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPDZ (select a term)
intoGenMPDZ
Cancer3DMPDZ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603785    615219   
Orphanet20252   
MedgenMPDZ
Genetic Testing Registry MPDZ
NextProtO75970 [Medical]
TSGene8777
GENETestsMPDZ
Target ValidationMPDZ
Huge Navigator MPDZ [HugePedia]
snp3D : Map Gene to Disease8777
BioCentury BCIQMPDZ
ClinGenMPDZ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8777
Chemical/Pharm GKB GenePA30914
Clinical trialMPDZ
Miscellaneous
canSAR (ICR)MPDZ (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPDZ
EVEXMPDZ
GoPubMedMPDZ
iHOPMPDZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:31:16 CEST 2017

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