MPI (mannose phosphate isomerase)

2014-11-01  

Identity

HGNC
LOCATION
15q24.1
LOCUSID
ALIAS
CDG1B,PMI,PMI1

Other Information

Locus ID:

NCBI: 4351
MIM: 154550
HGNC: 7216
Ensembl: ENSG00000178802

Variants:

dbSNP: 4351
ClinVar: 4351
TCGA: ENSG00000178802
COSMIC: MPI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178802ENST00000323744P34949
ENSG00000178802ENST00000352410P34949
ENSG00000178802ENST00000535694F5GX71
ENSG00000178802ENST00000561470H3BM77
ENSG00000178802ENST00000562606H3BT48
ENSG00000178802ENST00000562800H3BUG1
ENSG00000178802ENST00000563422H3BUZ9
ENSG00000178802ENST00000563786H3BPB8
ENSG00000178802ENST00000564003B4DYB8
ENSG00000178802ENST00000564633H3BPM5
ENSG00000178802ENST00000565576H3BMZ9
ENSG00000178802ENST00000566377H3BPP3
ENSG00000178802ENST00000567132H3BQX0
ENSG00000178802ENST00000567177H3BT46
ENSG00000178802ENST00000567570H3BPU7
ENSG00000178802ENST00000568828H3BNY8
ENSG00000178802ENST00000568907H3BU66
ENSG00000178802ENST00000569233H3BN01
ENSG00000178802ENST00000569931H3BP57

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Fructose and mannose metabolismKEGGko00051
Amino sugar and nucleotide sugar metabolismKEGGko00520
Fructose and mannose metabolismKEGGhsa00051
Amino sugar and nucleotide sugar metabolismKEGGhsa00520
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinREACTOMER-HSA-446193
Synthesis of substrates in N-glycan biosythesisREACTOMER-HSA-446219
Synthesis of GDP-mannoseREACTOMER-HSA-446205

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
219492372011Phosphomannose isomerase inhibitors improve N-glycosylation in selected phosphomannomutase-deficient fibroblasts.22
286441272017MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect.6
164881692006Computational study of human phosphomannose isomerase: Insights from homology modeling and molecular dynamics simulation of enzyme bound substrate.1
310167442019Mannose Phosphate Isomerase and Mannose Regulate Hepatic Stellate Cell Activation and Fibrosis in Zebrafish and Humans.0

Citation

Dessen P

MPI (mannose phosphate isomerase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/70392/mpi