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MPL (MPL proto-oncogene, thrombopoietin receptor)

Identity

Alias_namesmyeloproliferative leukemia virus oncogene
Alias_symbol (synonym)CD110
TPOR
Other aliasC-MPL
MPLV
THCYT2
HGNC (Hugo) MPL
LocusID (NCBI) 4352
Atlas_Id 41419
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 43337804 and ends at 43354464 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 8 ]
  Chronic Eosinophilic Leukemia-Not Otherwise Specified (CEL-NOS)::Idiopathic Hypereosinophilic Syndrome (IHES)
Classification of myelodysplastic syndromes 2015
Essential Thrombocythemia (ET)
Myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)
Myelodysplastic/myeloproliferative neoplasms
Myelofibrosis with Myeloid Metaplasia (MMM)::Idiopathic myelofibrosis::Agnogenic myeloid metaplasia
t(5;9)(q32;p24) KANK1/PDGFRB
t(11;14)(p15;q22) AP2A2/NID2

External links

Nomenclature
HGNC (Hugo)MPL   7217
LRG (Locus Reference Genomic)LRG_510
Cards
Entrez_Gene (NCBI)MPL  4352  MPL proto-oncogene, thrombopoietin receptor
AliasesC-MPL; CD110; MPLV; THCYT2; 
TPOR
GeneCards (Weizmann)MPL
Ensembl hg19 (Hinxton)ENSG00000117400 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117400 [Gene_View]  ENSG00000117400 [Sequence]  chr1:43337804-43354464 [Contig_View]  MPL [Vega]
ICGC DataPortalENSG00000117400
TCGA cBioPortalMPL
AceView (NCBI)MPL
Genatlas (Paris)MPL
WikiGenes4352
SOURCE (Princeton)MPL
Genetics Home Reference (NIH)MPL
Genomic and cartography
GoldenPath hg38 (UCSC)MPL  -     chr1:43337804-43354464 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPL  -     1p34.2   [Description]    (hg19-Feb_2009)
EnsemblMPL - 1p34.2 [CytoView hg19]  MPL - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIMPL [Mapview hg19]  MPL [Mapview hg38]
OMIM159530   254450   601977   604498   
Gene and transcription
Genbank (Entrez)DQ234353 KF964490 M90102 M90103
RefSeq transcript (Entrez)NM_005373
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPL
Cluster EST : UnigeneHs.82906 [ NCBI ]
CGAP (NCI)Hs.82906
Alternative Splicing GalleryENSG00000117400
Gene ExpressionMPL [ NCBI-GEO ]   MPL [ EBI - ARRAY_EXPRESS ]   MPL [ SEEK ]   MPL [ MEM ]
Gene Expression Viewer (FireBrowse)MPL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4352
GTEX Portal (Tissue expression)MPL
Human Protein AtlasENSG00000117400-MPL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40238   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40238  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40238
Splice isoforms : SwissVarP40238
PhosPhoSitePlusP40238
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F1 (PS01352)   
Domains : Interpro (EBI)FN3_dom    FN3_sf    Growth/epo_recpt_lig-bind    Ig-like_fold    Long_hematopoietin_rcpt_CS   
Domain families : Pfam (Sanger)EpoR_lig-bind (PF09067)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam09067    pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
Conserved Domain (NCBI)MPL
DMDM Disease mutations4352
Blocks (Seattle)MPL
SuperfamilyP40238
Human Protein Atlas [tissue]ENSG00000117400-MPL [tissue]
Peptide AtlasP40238
HPRD01161
IPIIPI00027637   IPI00218148   IPI00873673   
Protein Interaction databases
DIP (DOE-UCLA)P40238
IntAct (EBI)P40238
FunCoupENSG00000117400
BioGRIDMPL
STRING (EMBL)MPL
ZODIACMPL
Ontologies - Pathways
QuickGOP40238
Ontology : AmiGOneutrophil homeostasis  transmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  cell proliferation  cell surface  monocyte homeostasis  thrombopoietin-mediated signaling pathway  thrombopoietin receptor activity  neuron projection  neuronal cell body  positive regulation of lymphocyte proliferation  platelet aggregation  cellular response to hypoxia  positive regulation of platelet formation  eosinophil homeostasis  basophil homeostasis  
Ontology : EGO-EBIneutrophil homeostasis  transmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  cell proliferation  cell surface  monocyte homeostasis  thrombopoietin-mediated signaling pathway  thrombopoietin receptor activity  neuron projection  neuronal cell body  positive regulation of lymphocyte proliferation  platelet aggregation  cellular response to hypoxia  positive regulation of platelet formation  eosinophil homeostasis  basophil homeostasis  
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
NDEx NetworkMPL
Atlas of Cancer Signalling NetworkMPL
Wikipedia pathwaysMPL
Orthology - Evolution
OrthoDB4352
GeneTree (enSembl)ENSG00000117400
Phylogenetic Trees/Animal Genes : TreeFamMPL
HOVERGENP40238
HOGENOMP40238
Homologs : HomoloGeneMPL
Homology/Alignments : Family Browser (UCSC)MPL
Gene fusions - Rearrangements
Fusion : QuiverMPL
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPL
dbVarMPL
ClinVarMPL
1000_GenomesMPL 
Exome Variant ServerMPL
ExAC (Exome Aggregation Consortium)ENSG00000117400
GNOMAD BrowserENSG00000117400
Varsome BrowserMPL
Genetic variants : HAPMAP4352
Genomic Variants (DGV)MPL [DGVbeta]
DECIPHERMPL [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMPL 
Mutations
ICGC Data PortalMPL 
TCGA Data PortalMPL 
Broad Tumor PortalMPL
OASIS PortalMPL [ Somatic mutations - Copy number]
Cancer Gene: CensusMPL 
Somatic Mutations in Cancer : COSMICMPL  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMPL
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch MPL
DgiDB (Drug Gene Interaction Database)MPL
DoCM (Curated mutations)MPL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPL (select a term)
intoGenMPL
Cancer3DMPL(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM159530    254450    601977    604498   
Orphanet3053    3599    22692    8745    8747    11014   
DisGeNETMPL
MedgenMPL
Genetic Testing Registry MPL
NextProtP40238 [Medical]
TSGene4352
GENETestsMPL
Target ValidationMPL
Huge Navigator MPL [HugePedia]
snp3D : Map Gene to Disease4352
BioCentury BCIQMPL
ClinGenMPL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4352
Chemical/Pharm GKB GenePA30923
Clinical trialMPL
Miscellaneous
canSAR (ICR)MPL (select the gene name)
Probes
Litterature
PubMed187 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPL
EVEXMPL
GoPubMedMPL
iHOPMPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 11:38:34 CEST 2018
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