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MPL (MPL proto-oncogene, thrombopoietin receptor)

Identity

Other namesC-MPL
CD110
MPLV
THCYT2
TPOR
HGNC (Hugo) MPL
LocusID (NCBI) 4352
Atlas_Id 41419
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 43803475 and ends at 43820135 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  Classification of myelodysplastic syndromes 2015
Essential Thrombocythemia (ET)
Myelofibrosis with Myeloid Metaplasia (MMM);Idiopathic myelofibrosis;Agnogenic myeloid metaplasia
t(5;9)(q32;p24) KANK1/PDGFRB
t(11;14)(p15;q22) AP2A2/NID2

External links

Nomenclature
HGNC (Hugo)MPL   7217
Cards
Entrez_Gene (NCBI)MPL  4352  MPL proto-oncogene, thrombopoietin receptor
AliasesC-MPL; CD110; MPLV; THCYT2; 
TPOR
GeneCards (Weizmann)MPL
Ensembl hg19 (Hinxton)ENSG00000117400 [Gene_View]  chr1:43803475-43820135 [Contig_View]  MPL [Vega]
Ensembl hg38 (Hinxton)ENSG00000117400 [Gene_View]  chr1:43803475-43820135 [Contig_View]  MPL [Vega]
ICGC DataPortalENSG00000117400
TCGA cBioPortalMPL
AceView (NCBI)MPL
Genatlas (Paris)MPL
WikiGenes4352
SOURCE (Princeton)MPL
Genomic and cartography
GoldenPath hg19 (UCSC)MPL  -     chr1:43803475-43820135 +  1p34.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MPL  -     1p34.2   [Description]    (hg38-Dec_2013)
EnsemblMPL - 1p34.2 [CytoView hg19]  MPL - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIMPL [Mapview hg19]  MPL [Mapview hg38]
OMIM159530   254450   601977   604498   
Gene and transcription
Genbank (Entrez)BC140298 BC153092 DQ234353 KF964490 M90102
RefSeq transcript (Entrez)NM_005373
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_007525 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)MPL
Cluster EST : UnigeneHs.82906 [ NCBI ]
CGAP (NCI)Hs.82906
Alternative Splicing GalleryENSG00000117400
Gene ExpressionMPL [ NCBI-GEO ]   MPL [ EBI - ARRAY_EXPRESS ]   MPL [ SEEK ]   MPL [ MEM ]
Gene Expression Viewer (FireBrowse)MPL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4352
GTEX Portal (Tissue expression)MPL
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40238 (Uniprot)
NextProtP40238  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40238
Splice isoforms : SwissVarP40238 (Swissvar)
PhosPhoSitePlusP40238
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F1 (PS01352)   
Domains : Interpro (EBI)FN3_dom    Growth/epo_recpt_lig-bind    Ig-like_fold    Long_hematopoietin_rcpt_CS   
Domain families : Pfam (Sanger)EpoR_lig-bind (PF09067)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam09067    pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations4352
Blocks (Seattle)MPL
SuperfamilyP40238
Human Protein AtlasENSG00000117400
Peptide AtlasP40238
HPRD01161
IPIIPI00027637   IPI00218148   IPI00873673   
Protein Interaction databases
DIP (DOE-UCLA)P40238
IntAct (EBI)P40238
FunCoupENSG00000117400
BioGRIDMPL
STRING (EMBL)MPL
ZODIACMPL
Ontologies - Pathways
QuickGOP40238
Ontology : AmiGOtransmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  cell proliferation  cell surface  thrombopoietin-mediated signaling pathway  thrombopoietin receptor activity  
Ontology : EGO-EBItransmembrane signaling receptor activity  protein binding  Golgi apparatus  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  cell proliferation  cell surface  thrombopoietin-mediated signaling pathway  thrombopoietin receptor activity  
Pathways : BIOCARTATPO Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkMPL
Wikipedia pathwaysMPL
Orthology - Evolution
OrthoDB4352
GeneTree (enSembl)ENSG00000117400
Phylogenetic Trees/Animal Genes : TreeFamMPL
Homologs : HomoloGeneMPL
Homology/Alignments : Family Browser (UCSC)MPL
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMPL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPL
dbVarMPL
ClinVarMPL
1000_GenomesMPL 
Exome Variant ServerMPL
ExAC (Exome Aggregation Consortium)MPL (select the gene name)
Genetic variants : HAPMAP4352
Genomic Variants (DGV)MPL [DGVbeta]
Mutations
ICGC Data PortalMPL 
TCGA Data PortalMPL 
Broad Tumor PortalMPL
OASIS PortalMPL [ Somatic mutations - Copy number]
Cancer Gene: CensusMPL 
Somatic Mutations in Cancer : COSMICMPL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch MPL
DgiDB (Drug Gene Interaction Database)MPL
DoCM (Curated mutations)MPL (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPL (select a term)
intoGenMPL
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:43803475-43820135  ENSG00000117400
CONAN: Copy Number AnalysisMPL 
Mutations and Diseases : HGMDMPL
OMIM159530    254450    601977    604498   
MedgenMPL
Genetic Testing Registry MPL
NextProtP40238 [Medical]
TSGene4352
GENETestsMPL
Huge Navigator MPL [HugePedia]
snp3D : Map Gene to Disease4352
BioCentury BCIQMPL
ClinGenMPL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4352
Chemical/Pharm GKB GenePA30923
Clinical trialMPL
Miscellaneous
canSAR (ICR)MPL (select the gene name)
Probes
Litterature
PubMed162 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPL
EVEXMPL
GoPubMedMPL
iHOPMPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:05:48 CEST 2016

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