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MPL (MPL proto-oncogene, thrombopoietin receptor)

Identity

Other namesC-MPL
CD110
MPLV
THCYT2
TPOR
HGNC (Hugo) MPL
LocusID (NCBI) 4352
Location 1p34.2
Location_base_pair Starts at 43803475 and ends at 43820135 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias t0817q24q22ID1494 t1119q23p13ID1540 t614p25q32IRF4IGHID1175

External links

Nomenclature
HGNC (Hugo)MPL   7217
Cards
Entrez_Gene (NCBI)MPL  4352  MPL proto-oncogene, thrombopoietin receptor
GeneCards (Weizmann)MPL
Ensembl (Hinxton)ENSG00000117400 [Gene_View]  chr1:43803475-43820135 [Contig_View]  MPL [Vega]
ICGC DataPortalENSG00000117400
cBioPortalMPL
AceView (NCBI)MPL
Genatlas (Paris)MPL
WikiGenes4352
SOURCE (Princeton)NM_005373
Genomic and cartography
GoldenPath (UCSC)MPL  -  1p34.2   chr1:43803475-43820135 +  1p34.2   [Description]    (hg19-Feb_2009)
EnsemblMPL - 1p34.2 [CytoView]
Mapping of homologs : NCBIMPL [Mapview]
OMIM159530   254450   601977   604498   
Gene and transcription
Genbank (Entrez)BC140298 BC153092 DQ234353 KF964490 M90102
RefSeq transcript (Entrez)NM_005373
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007525 NT_032977 NW_001838578 NW_004929290
Consensus coding sequences : CCDS (NCBI)MPL
Cluster EST : UnigeneHs.82906 [ NCBI ]
CGAP (NCI)Hs.82906
Alternative Splicing : Fast-db (Paris)GSHG0000445
Alternative Splicing GalleryENSG00000117400
Gene ExpressionMPL [ NCBI-GEO ]     MPL [ SEEK ]   MPL [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40238 (Uniprot)
NextProtP40238  [Medical]
With graphics : InterProP40238
Splice isoforms : SwissVarP40238 (Swissvar)
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F1 (PS01352)   
Domains : Interpro (EBI)Fibronectin_type3 [organisation]   Growth/epo_recpt_lig-bind [organisation]   Ig-like_fold [organisation]   Long_hematopoietin_rcpt_CS [organisation]  
Related proteins : CluSTrP40238
Domain families : Pfam (Sanger)EpoR_lig-bind (PF09067)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam09067    pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations4352
Blocks (Seattle)P40238
Human Protein AtlasENSG00000117400 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP40238
HPRD01161
IPIIPI00027637   IPI00218148   IPI00873673   
Protein Interaction databases
DIP (DOE-UCLA)P40238
IntAct (EBI)P40238
FunCoupENSG00000117400
BioGRIDMPL
InParanoidP40238
Interologous Interaction database P40238
IntegromeDBMPL
STRING (EMBL)MPL
Ontologies - Pathways
Ontology : AmiGOtransmembrane signaling receptor activity  cytokine receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  blood coagulation  cell proliferation  cytokine-mediated signaling pathway  platelet activation  regulation of chemokine production  homeostasis of number of cells  
Ontology : EGO-EBItransmembrane signaling receptor activity  cytokine receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  blood coagulation  cell proliferation  cytokine-mediated signaling pathway  platelet activation  regulation of chemokine production  homeostasis of number of cells  
Pathways : BIOCARTATPO Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
Protein Interaction DatabaseMPL
Wikipedia pathwaysMPL
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MPL
snp3D : Map Gene to Disease4352
SNP (GeneSNP Utah)MPL
SNP : HGBaseMPL
Genetic variants : HAPMAPMPL
Exome VariantMPL
1000_GenomesMPL 
ICGC programENSG00000117400 
Cancer Gene: CensusMPL 
Somatic Mutations in Cancer : COSMICMPL 
CONAN: Copy Number AnalysisMPL 
Mutations and Diseases : HGMDMPL
Genomic VariantsMPL  MPL [DGVbeta]
dbVarMPL
ClinVarMPL
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM159530    254450    601977    604498   
MedgenMPL
GENETestsMPL
Disease Genetic AssociationMPL
Huge Navigator MPL [HugePedia]  MPL [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMPL
Homology/Alignments : Family Browser (UCSC)MPL
Phylogenetic Trees/Animal Genes : TreeFamMPL
Chemical/Protein Interactions : CTD4352
Chemical/Pharm GKB GenePA30923
Clinical trialMPL
Cancer Resource (Charite)ENSG00000117400
Other databases
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
CoreMineMPL
iHOPMPL
OncoSearchMPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:06:29 CEST 2014
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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.