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MPL (MPL proto-oncogene, thrombopoietin receptor)

Identity

Other namesC-MPL
CD110
MPLV
THCYT2
TPOR
HGNC (Hugo) MPL
LocusID (NCBI) 4352
Location 1p34.2
Location_base_pair Starts at 43803475 and ends at 43820135 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615 11q23ID1030 11q23secondLeukID1131

External links

Nomenclature
HGNC (Hugo)MPL   7217
Cards
Entrez_Gene (NCBI)MPL  4352  MPL proto-oncogene, thrombopoietin receptor
GeneCards (Weizmann)MPL
Ensembl hg19 (Hinxton)ENSG00000117400 [Gene_View]  chr1:43803475-43820135 [Contig_View]  MPL [Vega]
Ensembl hg38 (Hinxton)ENSG00000117400 [Gene_View]  chr1:43803475-43820135 [Contig_View]  MPL [Vega]
ICGC DataPortalENSG00000117400
cBioPortalMPL
AceView (NCBI)MPL
Genatlas (Paris)MPL
WikiGenes4352
SOURCE (Princeton)MPL
Genomic and cartography
GoldenPath hg19 (UCSC)MPL  -     chr1:43803475-43820135 +  1p34.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MPL  -     1p34.2   [Description]    (hg38-Dec_2013)
EnsemblMPL - 1p34.2 [CytoView hg19]  MPL - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIMPL [Mapview hg19]  MPL [Mapview hg38]
OMIM159530   254450   601977   604498   
Gene and transcription
Genbank (Entrez)BC140298 BC153092 DQ234353 KF964490 M90102
RefSeq transcript (Entrez)NM_005373
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007525 NT_032977 NW_001838578 NW_004929290
Consensus coding sequences : CCDS (NCBI)MPL
Cluster EST : UnigeneHs.82906 [ NCBI ]
CGAP (NCI)Hs.82906
Alternative Splicing : Fast-db (Paris)GSHG0000445
Alternative Splicing GalleryENSG00000117400
Gene ExpressionMPL [ NCBI-GEO ]     MPL [ SEEK ]   MPL [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40238 (Uniprot)
NextProtP40238  [Medical]
With graphics : InterProP40238
Splice isoforms : SwissVarP40238 (Swissvar)
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F1 (PS01352)   
Domains : Interpro (EBI)Fibronectin_type3    Growth/epo_recpt_lig-bind    Ig-like_fold    Long_hematopoietin_rcpt_CS   
Related proteins : CluSTrP40238
Domain families : Pfam (Sanger)EpoR_lig-bind (PF09067)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam09067    pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM Disease mutations4352
Blocks (Seattle)P40238
Human Protein AtlasENSG00000117400
Peptide AtlasP40238
HPRD01161
IPIIPI00027637   IPI00218148   IPI00873673   
Protein Interaction databases
DIP (DOE-UCLA)P40238
IntAct (EBI)P40238
FunCoupENSG00000117400
BioGRIDMPL
IntegromeDBMPL
STRING (EMBL)MPL
Ontologies - Pathways
QuickGOP40238
Ontology : AmiGOtransmembrane signaling receptor activity  cytokine receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  blood coagulation  cell proliferation  cytokine-mediated signaling pathway  platelet activation  regulation of chemokine production  homeostasis of number of cells  
Ontology : EGO-EBItransmembrane signaling receptor activity  cytokine receptor activity  plasma membrane  plasma membrane  integral component of plasma membrane  cell surface receptor signaling pathway  blood coagulation  cell proliferation  cytokine-mediated signaling pathway  platelet activation  regulation of chemokine production  homeostasis of number of cells  
Pathways : BIOCARTATPO Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interaction    Jak-STAT signaling pathway   
Protein Interaction DatabaseMPL
DoCM (Curated mutations)MPL
Wikipedia pathwaysMPL
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMPL [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPL
dbVarMPL
ClinVarMPL
1000_GenomesMPL 
Exome Variant ServerMPL
SNP (GeneSNP Utah)MPL
SNP : HGBaseMPL
Genetic variants : HAPMAPMPL
Genomic VariantsMPL  MPL [DGVbeta]
Mutations
ICGC Data PortalENSG00000117400 
Cancer Gene: CensusMPL 
Somatic Mutations in Cancer : COSMICMPL 
CONAN: Copy Number AnalysisMPL 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:43803475-43820135
Mutations and Diseases : HGMDMPL
OMIM159530    254450    601977    604498   
MedgenMPL
NextProtP40238 [Medical]
GENETestsMPL
Disease Genetic AssociationMPL
Huge Navigator MPL [HugePedia]  MPL [HugeCancerGEM]
snp3D : Map Gene to Disease4352
DGIdb (Drug Gene Interaction db)MPL
General knowledge
Homologs : HomoloGeneMPL
Homology/Alignments : Family Browser (UCSC)MPL
Phylogenetic Trees/Animal Genes : TreeFamMPL
Chemical/Protein Interactions : CTD4352
Chemical/Pharm GKB GenePA30923
Clinical trialMPL
Cancer Resource (Charite)ENSG00000117400
Other databases
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
CoreMineMPL
GoPubMedMPL
iHOPMPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 00:17:38 CET 2014
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