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MPL (myeloproliferative leukemia virus oncogene)

Identity

Other namesC-MPL
CD110
MPLV
THCYT2
TPOR
HGNC (Hugo) MPL
LocusID (NCBI) 4352
Location 1p34.2
Location_base_pair Starts at 43803475 and ends at 43820135 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MPL   7217
Entrez_Gene (NCBI)MPL  4352  myeloproliferative leukemia virus oncogene
Cards
GeneCards (Weizmann)MPL
Ensembl (Hinxton)ENSG00000117400 [Gene_View]  chr1:43803475-43820135 [Contig_View]  MPL [Vega]
AceView (NCBI)MPL
Genatlas (Paris)MPL
SOURCE (Stanford)NM_005373
Genomic and cartography
GoldenPath (UCSC)MPL  -  1p34.2   chr1:43803475-43820135 +  1p34.2   [Description]    (hg19-Feb_2009)
EnsemblMPL - 1p34.2 [CytoView]
Mapping of homologs : NCBIMPL [Mapview]
OMIM159530   187950   254450   601977   604498   
Gene and transcription
Genbank (Entrez)BC140298 BC153092 DQ234353 M90102 M90103
RefSeq transcript (SRS)NM_005373
RefSeq transcript (Entrez)NM_005373
RefSeq genomic (SRS)AC_000133 NC_000001 NC_018912 NG_007525 NT_032977 NW_001838578 NW_004077990
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_007525 NT_032977 NW_001838578 NW_004077990
Consensus coding sequences : CCDS (NCBI)MPL
Cluster EST : UnigeneHs.82906 [ SRS ] Hs.82906 [ NCBI ]
CGAP (NCI)Hs.82906
Alternative Splicing : Fast-db (Paris)GSHG0000445
Alternative Splicing GalleryENSG00000117400
Gene ExpressionMPL [ NCBI-GEO ]   MPL [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40238 (SRS) P40238 (Uniprot)
NextProtP40238
With graphics : InterProP40238
Splice isoforms : SwissVarP40238(Swissvar)
Domaine pattern : Prosite (SRS)FN3 (PS50853)    HEMATOPO_REC_L_F1 (PS01352)   
Domaine pattern : Prosite (Expaxy)FN3 (PS50853)    HEMATOPO_REC_L_F1 (PS01352)   
Domains : Interpro (SRS)Fibronectin_type3    Growth/epo_recpt_lig-bind    Ig-like_fold    Long_hematopoietin_rcpt_CS   
Domains : Interpro (EBI)Fibronectin_type3    Growth/epo_recpt_lig-bind    Ig-like_fold    Long_hematopoietin_rcpt_CS   
Related proteins : CluSTrP40238
Domain families : Pfam (SRS)EpoR_lig-bind (PF09067)    fn3 (PF00041)   
Domain families : Pfam (Sanger)EpoR_lig-bind (PF09067)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam09067    pfam00041   
Domain families : Smart (EMBL)FN3 (SM00060)  
DMDM4352
Blocks (Seattle)P40238
Human Protein AtlasENSG00000117400
HPRD01161
IPIIPI00027637   IPI00218148   IPI00873673   
Protein Interaction databases
DIP (DOE-UCLA)P40238
IntAct (EBI)P40238
FunCoupENSG00000117400
REACTOMEMPL
Protein Interaction Database4352
BioGRIDMPL
InParanoidP40238
Interologous Interaction database P40238
IntegromeDBMPL
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MPL
SNP (GeneSNP Utah)MPL
SNP : HGBaseMPL
Genetic variants : HAPMAPMPL
Cancer Gene: CensusMPL 
Somatic Mutations in Cancer : COSMICMPL 
CONAN: Copy Number AnalysisMPL 
Mutations and Diseases : HGMDMPL
OMIM159530    187950    254450    601977    604498   
GENETests159530    187950    254450    601977    604498   
Disease Genetic AssociationMPL
Huge Navigator MPL [HugePedia]  MPL [HugeCancerGEM]
Genomic VariantsMPL  MPL [DGVbeta]
snp3D : Map Gene to Disease4352
General knowledge
Homologs : HomoloGeneMPL
Homology/Alignments : Family Browser (UCSC)MPL
Phylogenetic Trees/Animal Genes : TreeFamMPL
Chemical/Protein Interactions : CTD4352
Chemical/Pharm GKB GenePA30923
Clinical trialMPL
Cancer Resource (Charite)ENSG00000117400
Ontology : AmiGOtransmembrane signaling receptor activity  cytokine receptor activity  plasma membrane  plasma membrane  integral to plasma membrane  cell surface receptor signaling pathway  blood coagulation  cell proliferation  platelet activation  regulation of chemokine production  homeostasis of number of cells  
Ontology : EGO-EBItransmembrane signaling receptor activity  cytokine receptor activity  plasma membrane  plasma membrane  integral to plasma membrane  cell surface receptor signaling pathway  blood coagulation  cell proliferation  platelet activation  regulation of chemokine production  homeostasis of number of cells  
Pathways : BIOCARTATPO Signaling Pathway [Genes]   
Pathways : KEGGCytokine-cytokine receptor interactionJak-STAT signaling pathway
Other databases
Probes
Litterature
PubMed133 Pubmed reference(s) in Entrez
PubGeneMPL
iHOPMPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:19:37 CEST 2013
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