Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MPL (MPL proto-oncogene, thrombopoietin receptor)

Identity

Alias_namesmyeloproliferative leukemia virus oncogene
Alias_symbol (synonym)CD110
TPOR
THPOR
Other aliasC-MPL
MPLV
THCYT2
HGNC (Hugo) MPL
LocusID (NCBI) 4352
Atlas_Id 41419
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 43337804 and ends at 43354464 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias MDS-MPN-RS-TID1396

External links

Nomenclature
HGNC (Hugo)MPL   7217
LRG (Locus Reference Genomic)LRG_510
Cards
Entrez_Gene (NCBI)MPL  4352  MPL proto-oncogene, thrombopoietin receptor
AliasesC-MPL; CD110; MPLV; THCYT2; 
THPOR; TPOR
GeneCards (Weizmann)MPL
Ensembl hg19 (Hinxton)ENSG00000117400 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117400 [Gene_View]  ENSG00000117400 [Sequence]  chr1:43337804-43354464 [Contig_View]  MPL [Vega]
ICGC DataPortalENSG00000117400
TCGA cBioPortalMPL
AceView (NCBI)MPL
Genatlas (Paris)MPL
WikiGenes4352
SOURCE (Princeton)MPL
Genetics Home Reference (NIH)MPL
Genomic and cartography
GoldenPath hg38 (UCSC)MPL  -     chr1:43337804-43354464 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPL  -     1p34.2   [Description]    (hg19-Feb_2009)
GoldenPathMPL - 1p34.2 [CytoView hg19]  MPL - 1p34.2 [CytoView hg38]
ImmunoBaseENSG00000117400
Mapping of homologs : NCBIMPL [Mapview hg19]  MPL [Mapview hg38]
OMIM159530   254450   601977   604498   
Gene and transcription
Genbank (Entrez)DQ234353 KF964490 M90102 M90103
RefSeq transcript (Entrez)NM_005373
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPL
Alternative Splicing GalleryENSG00000117400
Gene ExpressionMPL [ NCBI-GEO ]   MPL [ EBI - ARRAY_EXPRESS ]   MPL [ SEEK ]   MPL [ MEM ]
Gene Expression Viewer (FireBrowse)MPL [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4352
GTEX Portal (Tissue expression)MPL
Human Protein AtlasENSG00000117400-MPL [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MPL
DMDM Disease mutations4352
Blocks (Seattle)MPL
Human Protein Atlas [tissue]ENSG00000117400-MPL [tissue]
HPRD01161
IPIIPI00027637   IPI00218148   IPI00873673   
Protein Interaction databases
FunCoupENSG00000117400
BioGRIDMPL
STRING (EMBL)MPL
ZODIACMPL
Ontologies - Pathways
Huge Navigator MPL [HugePedia]
snp3D : Map Gene to Disease4352
BioCentury BCIQMPL
ClinGenMPL
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4352
Chemical/Pharm GKB GenePA30923
Clinical trialMPL
Miscellaneous
canSAR (ICR)MPL (select the gene name)
DataMed IndexMPL
Probes
Litterature
PubMed204 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPL
EVEXMPL
GoPubMedMPL
iHOPMPL
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 19 16:57:16 CET 2020
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