Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MPO (myeloperoxidase)

Identity

Alias (NCBI)-
HGNC (Hugo) MPO
LocusID (NCBI) 4353
Atlas_Id 43627
Location 17q22  [Link to chromosome band 17q22]
Location_base_pair Starts at 58269855 and ends at 58280935 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AATF (17q12) / MPO (17q22)LOXL4 (10q24.2) / MPO (17q22)MBP (18q23) / MPO (17q22)
MPO (17q22) / ACSL1 (4q35.1)MPO (17q22) / FAR1 (11p15.2)MPO (17q22) / MPO (17q22)
MPO (17q22) / RPLP1 (15q23)MPO (17q22) / ZNF296 (19q13.32)SEPT9 (17q25.2) / MPO (17q22)
ZNFX1 (20q13.13) / MPO (17q22)MPO 17q22 / FAR1 11p15.2SEPT9 17q25.2 / MPO 17q22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  der(17)t(17;17)(p13;q12-21)
t(11;17)(p15;q22) MPO/FAR1
t(17;19)(q22;q13) MPO/ZNF296

External links

Nomenclature
HGNC (Hugo)MPO   7218
LRG (Locus Reference Genomic)LRG_84
Cards
Entrez_Gene (NCBI)MPO    myeloperoxidase
Aliases
GeneCards (Weizmann)MPO
Ensembl hg19 (Hinxton)ENSG00000005381 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000005381 [Gene_View]  ENSG00000005381 [Sequence]  chr17:58269855-58280935 [Contig_View]  MPO [Vega]
ICGC DataPortalENSG00000005381
TCGA cBioPortalMPO
AceView (NCBI)MPO
Genatlas (Paris)MPO
SOURCE (Princeton)MPO
Genetics Home Reference (NIH)MPO
Genomic and cartography
GoldenPath hg38 (UCSC)MPO  -     chr17:58269855-58280935 -  17q22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPO  -     17q22   [Description]    (hg19-Feb_2009)
GoldenPathMPO - 17q22 [CytoView hg19]  MPO - 17q22 [CytoView hg38]
ImmunoBaseENSG00000005381
genome Data Viewer NCBIMPO [Mapview hg19]  
OMIM104300   254600   606989   
Gene and transcription
Genbank (Entrez)BC130476 J02694 M19507 S56200 X04876
RefSeq transcript (Entrez)NM_000250
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPO
Alternative Splicing GalleryENSG00000005381
Gene ExpressionMPO [ NCBI-GEO ]   MPO [ EBI - ARRAY_EXPRESS ]   MPO [ SEEK ]   MPO [ MEM ]
Gene Expression Viewer (FireBrowse)MPO [ Firebrowse - Broad ]
GenevisibleExpression of MPO in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4353
GTEX Portal (Tissue expression)MPO
Human Protein AtlasENSG00000005381-MPO [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05164   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05164  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05164
Splice isoforms : SwissVarP05164
PhosPhoSitePlusP05164
Domaine pattern : Prosite (Expaxy)PEROXIDASE_1 (PS00435)    PEROXIDASE_3 (PS50292)   
Domains : Interpro (EBI)Haem_peroxidase_animal    Haem_peroxidase_sf    Haem_peroxidase_sf_animal    MPO   
Domain families : Pfam (Sanger)An_peroxidase (PF03098)   
Domain families : Pfam (NCBI)pfam03098   
Conserved Domain (NCBI)MPO
Blocks (Seattle)MPO
PDB (RSDB)1CXP    1D2V    1D5L    1D7W    1DNU    1DNW    1MHL    1MYP    3F9P    3ZS0    3ZS1    4C1M    4DL1    4EJX    5FIW    5MFA    5UZU    6AZP    6BMT   
PDB Europe1CXP    1D2V    1D5L    1D7W    1DNU    1DNW    1MHL    1MYP    3F9P    3ZS0    3ZS1    4C1M    4DL1    4EJX    5FIW    5MFA    5UZU    6AZP    6BMT   
PDB (PDBSum)1CXP    1D2V    1D5L    1D7W    1DNU    1DNW    1MHL    1MYP    3F9P    3ZS0    3ZS1    4C1M    4DL1    4EJX    5FIW    5MFA    5UZU    6AZP    6BMT   
PDB (IMB)1CXP    1D2V    1D5L    1D7W    1DNU    1DNW    1MHL    1MYP    3F9P    3ZS0    3ZS1    4C1M    4DL1    4EJX    5FIW    5MFA    5UZU    6AZP    6BMT   
Structural Biology KnowledgeBase1CXP    1D2V    1D5L    1D7W    1DNU    1DNW    1MHL    1MYP    3F9P    3ZS0    3ZS1    4C1M    4DL1    4EJX    5FIW    5MFA    5UZU    6AZP    6BMT   
SCOP (Structural Classification of Proteins)1CXP    1D2V    1D5L    1D7W    1DNU    1DNW    1MHL    1MYP    3F9P    3ZS0    3ZS1    4C1M    4DL1    4EJX    5FIW    5MFA    5UZU    6AZP    6BMT   
CATH (Classification of proteins structures)1CXP    1D2V    1D5L    1D7W    1DNU    1DNW    1MHL    1MYP    3F9P    3ZS0    3ZS1    4C1M    4DL1    4EJX    5FIW    5MFA    5UZU    6AZP    6BMT   
SuperfamilyP05164
Human Protein Atlas [tissue]ENSG00000005381-MPO [tissue]
Peptide AtlasP05164
HPRD06102
IPIIPI00007244   IPI00236554   IPI00236556   IPI00815852   
Protein Interaction databases
DIP (DOE-UCLA)P05164
IntAct (EBI)P05164
BioGRIDMPO
STRING (EMBL)MPO
ZODIACMPO
Ontologies - Pathways
QuickGOP05164
Ontology : AmiGOresponse to yeast  hypochlorous acid biosynthetic process  respiratory burst involved in defense response  chromatin binding  peroxidase activity  peroxidase activity  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  nucleus  nucleoplasm  lysosome  defense response  response to oxidative stress  aging  heparin binding  response to mechanical stimulus  removal of superoxide radicals  heme binding  secretory granule  response to food  response to lipopolysaccharide  low-density lipoprotein particle remodeling  azurophil granule lumen  azurophil granule  defense response to bacterium  hydrogen peroxide catabolic process  negative regulation of apoptotic process  intracellular membrane-bounded organelle  neutrophil degranulation  cell redox homeostasis  metal ion binding  defense response to fungus  extracellular exosome  phagocytic vesicle lumen  response to gold nanoparticle  
Ontology : EGO-EBIresponse to yeast  hypochlorous acid biosynthetic process  respiratory burst involved in defense response  chromatin binding  peroxidase activity  peroxidase activity  protein binding  extracellular region  extracellular space  extracellular space  extracellular space  nucleus  nucleoplasm  lysosome  defense response  response to oxidative stress  aging  heparin binding  response to mechanical stimulus  removal of superoxide radicals  heme binding  secretory granule  response to food  response to lipopolysaccharide  low-density lipoprotein particle remodeling  azurophil granule lumen  azurophil granule  defense response to bacterium  hydrogen peroxide catabolic process  negative regulation of apoptotic process  intracellular membrane-bounded organelle  neutrophil degranulation  cell redox homeostasis  metal ion binding  defense response to fungus  extracellular exosome  phagocytic vesicle lumen  response to gold nanoparticle  
Pathways : KEGGPhagosome    Transcriptional misregulation in cancer   
NDEx NetworkMPO
Atlas of Cancer Signalling NetworkMPO
Wikipedia pathwaysMPO
Orthology - Evolution
OrthoDB4353
GeneTree (enSembl)ENSG00000005381
Phylogenetic Trees/Animal Genes : TreeFamMPO
HOGENOMP05164
Homologs : HomoloGeneMPO
Homology/Alignments : Family Browser (UCSC)MPO
Gene fusions - Rearrangements
Fusion : MitelmanMPO/FAR1 [17q22/11p15.2]  
Fusion : MitelmanMPO/ZNF296 [17q22/19q13.32]  
Fusion : MitelmanSEPT9/MPO [17q25.2/17q22]  
Fusion PortalMPO 17q22 FAR1 11p15.2 LAML
Fusion PortalSEPT9 17q25.2 MPO 17q22 LUAD
Fusion : QuiverMPO
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPO [hg38]
dbVarMPO
ClinVarMPO
MonarchMPO
1000_GenomesMPO 
Exome Variant ServerMPO
GNOMAD BrowserENSG00000005381
Varsome BrowserMPO
Genomic Variants (DGV)MPO [DGVbeta]
DECIPHERMPO [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMPO 
Mutations
ICGC Data PortalMPO 
TCGA Data PortalMPO 
Broad Tumor PortalMPO
OASIS PortalMPO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMPO  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMPO
Mutations and Diseases : HGMDMPO
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MPO
DgiDB (Drug Gene Interaction Database)MPO
DoCM (Curated mutations)MPO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPO (select a term)
intoGenMPO
Cancer3DMPO(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104300    254600    606989   
Orphanet857   
DisGeNETMPO
MedgenMPO
Genetic Testing Registry MPO
NextProtP05164 [Medical]
GENETestsMPO
Target ValidationMPO
Huge Navigator MPO [HugePedia]
ClinGenMPO
Clinical trials, drugs, therapy
MyCancerGenomeMPO
Protein Interactions : CTD
Pharm GKB GenePA243
Pharm GKB PathwaysPA165817070   PA2025   
PharosP05164
Clinical trialMPO
Miscellaneous
canSAR (ICR)MPO (select the gene name)
HarmonizomeMPO
DataMed IndexMPO
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMPO
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:34:43 CET 2021
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