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MPP2 (membrane palmitoylated protein 2)

Identity

Alias_namesDLG2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
membrane protein, palmitoylated 2
Alias_symbol (synonym)DKFZp761D0712
Other alias
HGNC (Hugo) MPP2
LocusID (NCBI) 4355
Atlas_Id 41421
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 43875359 and ends at 43909711 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GPS2 (17p13.1) / MPP2 (17q21.31)MPP2 (17q21.31) / PPY (17q21.31)MPP2 17q21.31 / PPY 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MPP2   7220
Cards
Entrez_Gene (NCBI)MPP2  4355  membrane palmitoylated protein 2
AliasesDLG2
GeneCards (Weizmann)MPP2
Ensembl hg19 (Hinxton)ENSG00000108852 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108852 [Gene_View]  chr17:43875359-43909711 [Contig_View]  MPP2 [Vega]
ICGC DataPortalENSG00000108852
TCGA cBioPortalMPP2
AceView (NCBI)MPP2
Genatlas (Paris)MPP2
WikiGenes4355
SOURCE (Princeton)MPP2
Genetics Home Reference (NIH)MPP2
Genomic and cartography
GoldenPath hg38 (UCSC)MPP2  -     chr17:43875359-43909711 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPP2  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblMPP2 - 17q21.31 [CytoView hg19]  MPP2 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIMPP2 [Mapview hg19]  MPP2 [Mapview hg38]
OMIM600723   
Gene and transcription
Genbank (Entrez)AK223560 AK294564 AK295858 AK299286 AK299321
RefSeq transcript (Entrez)NM_001278370 NM_001278371 NM_001278372 NM_001278373 NM_001278374 NM_001278375 NM_001278376 NM_001278381 NM_005374
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPP2
Cluster EST : UnigeneHs.514208 [ NCBI ]
CGAP (NCI)Hs.514208
Alternative Splicing GalleryENSG00000108852
Gene ExpressionMPP2 [ NCBI-GEO ]   MPP2 [ EBI - ARRAY_EXPRESS ]   MPP2 [ SEEK ]   MPP2 [ MEM ]
Gene Expression Viewer (FireBrowse)MPP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4355
GTEX Portal (Tissue expression)MPP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14168   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14168  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14168
Splice isoforms : SwissVarQ14168
PhosPhoSitePlusQ14168
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_1 (PS00856)    GUANYLATE_KINASE_2 (PS50052)    L27 (PS51022)    PDZ (PS50106)    SH3 (PS50002)   
Domains : Interpro (EBI)GK/Ca_channel_bsu    Guanylate_kin-like_dom    Guanylate_kinase_CS    L27_C    L27_dom    P-loop_NTPase    PDZ    SH3_2    SH3_domain   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    L27 (PF02828)    PDZ (PF00595)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00625    pfam02828    pfam00595    pfam07653   
Domain families : Smart (EMBL)GuKc (SM00072)  L27 (SM00569)  PDZ (SM00228)  SH3 (SM00326)  
Conserved Domain (NCBI)MPP2
DMDM Disease mutations4355
Blocks (Seattle)MPP2
PDB (SRS)2E7K   
PDB (PDBSum)2E7K   
PDB (IMB)2E7K   
PDB (RSDB)2E7K   
Structural Biology KnowledgeBase2E7K   
SCOP (Structural Classification of Proteins)2E7K   
CATH (Classification of proteins structures)2E7K   
SuperfamilyQ14168
Human Protein AtlasENSG00000108852
Peptide AtlasQ14168
HPRD02837
IPIIPI01011986   IPI00956110   IPI00218271   IPI00910583   IPI00985464   IPI00982655   IPI00978551   IPI00984740   IPI00982582   IPI00984257   IPI00976600   IPI00981580   IPI00980847   IPI00981849   
Protein Interaction databases
DIP (DOE-UCLA)Q14168
IntAct (EBI)Q14168
FunCoupENSG00000108852
BioGRIDMPP2
STRING (EMBL)MPP2
ZODIACMPP2
Ontologies - Pathways
QuickGOQ14168
Ontology : AmiGOguanylate kinase activity  protein binding  cytoplasm  cytoskeleton  integral component of plasma membrane  signal transduction  postsynaptic density  membrane  dendrite membrane  dendritic spine membrane  dendritic spine  dendritic shaft  GMP metabolic process  GDP metabolic process  protein homooligomerization  excitatory postsynaptic potential  long-term synaptic potentiation  
Ontology : EGO-EBIguanylate kinase activity  protein binding  cytoplasm  cytoskeleton  integral component of plasma membrane  signal transduction  postsynaptic density  membrane  dendrite membrane  dendritic spine membrane  dendritic spine  dendritic shaft  GMP metabolic process  GDP metabolic process  protein homooligomerization  excitatory postsynaptic potential  long-term synaptic potentiation  
NDEx NetworkMPP2
Atlas of Cancer Signalling NetworkMPP2
Wikipedia pathwaysMPP2
Orthology - Evolution
OrthoDB4355
GeneTree (enSembl)ENSG00000108852
Phylogenetic Trees/Animal Genes : TreeFamMPP2
HOVERGENQ14168
HOGENOMQ14168
Homologs : HomoloGeneMPP2
Homology/Alignments : Family Browser (UCSC)MPP2
Gene fusions - Rearrangements
Fusion : MitelmanGPS2/MPP2 [17p13.1/17q21.31]  [t(17;17)(p13;q21)]  
Fusion : MitelmanMPP2/PPY [17q21.31/17q21.31]  [t(17;17)(q21;q21)]  
Fusion: TCGAMPP2 17q21.31 PPY 17q21.31 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPP2
dbVarMPP2
ClinVarMPP2
1000_GenomesMPP2 
Exome Variant ServerMPP2
ExAC (Exome Aggregation Consortium)MPP2 (select the gene name)
Genetic variants : HAPMAP4355
Genomic Variants (DGV)MPP2 [DGVbeta]
DECIPHERMPP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMPP2 
Mutations
ICGC Data PortalMPP2 
TCGA Data PortalMPP2 
Broad Tumor PortalMPP2
OASIS PortalMPP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMPP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMPP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MPP2
DgiDB (Drug Gene Interaction Database)MPP2
DoCM (Curated mutations)MPP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPP2 (select a term)
intoGenMPP2
Cancer3DMPP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600723   
Orphanet
MedgenMPP2
Genetic Testing Registry MPP2
NextProtQ14168 [Medical]
TSGene4355
GENETestsMPP2
Huge Navigator MPP2 [HugePedia]
snp3D : Map Gene to Disease4355
BioCentury BCIQMPP2
ClinGenMPP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4355
Chemical/Pharm GKB GenePA30925
Clinical trialMPP2
Miscellaneous
canSAR (ICR)MPP2 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPP2
EVEXMPP2
GoPubMedMPP2
iHOPMPP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:27:06 CEST 2017

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