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MPP5 (membrane palmitoylated protein 5)

Identity

Alias_namesmembrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
membrane protein, palmitoylated 5
Alias_symbol (synonym)PALS1
FLJ12615
Other alias
HGNC (Hugo) MPP5
LocusID (NCBI) 64398
Atlas_Id 41423
Location 14q23.3  [Link to chromosome band 14q23]
Location_base_pair Starts at 67708012 and ends at 67802778 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
KIAA0586 (14q23.1) / MPP5 (14q23.3)MPP5 (14q23.3) / FAM71D (14q23.3)MPP5 (14q23.3) / GPHN (14q23.3)
MPP5 (14q23.3) / RAD51B (14q24.1)MPP5 (14q23.3) / RDH11 (14q24.1)MPP5 (14q23.3) / SCRN3 (2q31.1)
TBL1X (Xp22.31) / MPP5 (14q23.3)KIAA0586 14q23.1 / MPP5 14q23.3MPP5 14q23.3 / GPHN 14q23.3
MPP5 14q23.3 / RAD51B 14q24.1MPP5 14q23.3 / RDH11 14q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MPP5   18669
Cards
Entrez_Gene (NCBI)MPP5  64398  membrane palmitoylated protein 5
AliasesPALS1
GeneCards (Weizmann)MPP5
Ensembl hg19 (Hinxton)ENSG00000072415 [Gene_View]  chr14:67708012-67802778 [Contig_View]  MPP5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000072415 [Gene_View]  chr14:67708012-67802778 [Contig_View]  MPP5 [Vega]
ICGC DataPortalENSG00000072415
TCGA cBioPortalMPP5
AceView (NCBI)MPP5
Genatlas (Paris)MPP5
WikiGenes64398
SOURCE (Princeton)MPP5
Genetics Home Reference (NIH)MPP5
Genomic and cartography
GoldenPath hg19 (UCSC)MPP5  -     chr14:67708012-67802778 +  14q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MPP5  -     14q23.3   [Description]    (hg38-Dec_2013)
EnsemblMPP5 - 14q23.3 [CytoView hg19]  MPP5 - 14q23.3 [CytoView hg38]
Mapping of homologs : NCBIMPP5 [Mapview hg19]  MPP5 [Mapview hg38]
OMIM606958   
Gene and transcription
Genbank (Entrez)AF131764 AI245706 AK022677 AK057160 AK098373
RefSeq transcript (Entrez)NM_001256550 NM_022474
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)MPP5
Cluster EST : UnigeneHs.740524 [ NCBI ]
CGAP (NCI)Hs.740524
Alternative Splicing GalleryENSG00000072415
Gene ExpressionMPP5 [ NCBI-GEO ]   MPP5 [ EBI - ARRAY_EXPRESS ]   MPP5 [ SEEK ]   MPP5 [ MEM ]
Gene Expression Viewer (FireBrowse)MPP5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64398
GTEX Portal (Tissue expression)MPP5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N3R9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N3R9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N3R9
Splice isoforms : SwissVarQ8N3R9
PhosPhoSitePlusQ8N3R9
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_1 (PS00856)    GUANYLATE_KINASE_2 (PS50052)    L27 (PS51022)    PDZ (PS50106)    SH3 (PS50002)   
Domains : Interpro (EBI)GK/Ca_channel_bsu    Guanylate_kin-like_dom    Guanylate_kinase_CS    L27_C    L27_dom    L27_N    MPP5    P-loop_NTPase    PDZ    SH3_2    SH3_domain   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    L27 (PF02828)    L27_N (PF09060)    PDZ (PF00595)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00625    pfam02828    pfam09060    pfam00595    pfam07653   
Domain families : Smart (EMBL)GuKc (SM00072)  L27 (SM00569)  PDZ (SM00228)  SH3 (SM00326)  
Conserved Domain (NCBI)MPP5
DMDM Disease mutations64398
Blocks (Seattle)MPP5
PDB (SRS)1Y76    3UIT    4UU5    4UU6    4WSI   
PDB (PDBSum)1Y76    3UIT    4UU5    4UU6    4WSI   
PDB (IMB)1Y76    3UIT    4UU5    4UU6    4WSI   
PDB (RSDB)1Y76    3UIT    4UU5    4UU6    4WSI   
Structural Biology KnowledgeBase1Y76    3UIT    4UU5    4UU6    4WSI   
SCOP (Structural Classification of Proteins)1Y76    3UIT    4UU5    4UU6    4WSI   
CATH (Classification of proteins structures)1Y76    3UIT    4UU5    4UU6    4WSI   
SuperfamilyQ8N3R9
Human Protein AtlasENSG00000072415
Peptide AtlasQ8N3R9
HPRD09508
IPIIPI00174976   IPI00604495   IPI01026316   IPI01026203   IPI01026435   
Protein Interaction databases
DIP (DOE-UCLA)Q8N3R9
IntAct (EBI)Q8N3R9
FunCoupENSG00000072415
BioGRIDMPP5
STRING (EMBL)MPP5
ZODIACMPP5
Ontologies - Pathways
QuickGOQ8N3R9
Ontology : AmiGOmorphogenesis of an epithelial sheet  protein binding  nucleoplasm  cytoplasm  plasma membrane  plasma membrane  bicellular tight junction  endomembrane system  protein domain specific binding  peripheral nervous system myelin maintenance  myelin assembly  myelin sheath adaxonal region  protein localization to myelin sheath abaxonal region  lateral loop  Schmidt-Lanterman incisure  protein complex  extracellular exosome  bicellular tight junction assembly  establishment of protein localization to plasma membrane  establishment of epithelial cell polarity  
Ontology : EGO-EBImorphogenesis of an epithelial sheet  protein binding  nucleoplasm  cytoplasm  plasma membrane  plasma membrane  bicellular tight junction  endomembrane system  protein domain specific binding  peripheral nervous system myelin maintenance  myelin assembly  myelin sheath adaxonal region  protein localization to myelin sheath abaxonal region  lateral loop  Schmidt-Lanterman incisure  protein complex  extracellular exosome  bicellular tight junction assembly  establishment of protein localization to plasma membrane  establishment of epithelial cell polarity  
Pathways : KEGGHippo signaling pathway    Tight junction   
NDEx NetworkMPP5
Atlas of Cancer Signalling NetworkMPP5
Wikipedia pathwaysMPP5
Orthology - Evolution
OrthoDB64398
GeneTree (enSembl)ENSG00000072415
Phylogenetic Trees/Animal Genes : TreeFamMPP5
HOVERGENQ8N3R9
HOGENOMQ8N3R9
Homologs : HomoloGeneMPP5
Homology/Alignments : Family Browser (UCSC)MPP5
Gene fusions - Rearrangements
Fusion : MitelmanKIAA0586/MPP5 [14q23.1/14q23.3]  [t(14;14)(q23;q23)]  
Fusion : MitelmanMPP5/FAM71D [14q23.3/14q23.3]  [t(14;14)(q23;q23)]  
Fusion : MitelmanMPP5/GPHN [14q23.3/14q23.3]  [t(14;14)(q23;q23)]  
Fusion : MitelmanMPP5/RAD51B [14q23.3/14q24.1]  [t(14;14)(q23;q24)]  
Fusion : MitelmanMPP5/RDH11 [14q23.3/14q24.1]  [t(14;14)(q23;q24)]  
Fusion: TCGAKIAA0586 14q23.1 MPP5 14q23.3 GBM
Fusion: TCGAMPP5 14q23.3 GPHN 14q23.3 BLCA BRCA LUAD
Fusion: TCGAMPP5 14q23.3 RAD51B 14q24.1 BRCA
Fusion: TCGAMPP5 14q23.3 RDH11 14q24.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPP5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPP5
dbVarMPP5
ClinVarMPP5
1000_GenomesMPP5 
Exome Variant ServerMPP5
ExAC (Exome Aggregation Consortium)MPP5 (select the gene name)
Genetic variants : HAPMAP64398
Genomic Variants (DGV)MPP5 [DGVbeta]
DECIPHER (Syndromes)14:67708012-67802778  ENSG00000072415
CONAN: Copy Number AnalysisMPP5 
Mutations
ICGC Data PortalMPP5 
TCGA Data PortalMPP5 
Broad Tumor PortalMPP5
OASIS PortalMPP5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMPP5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMPP5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MPP5
DgiDB (Drug Gene Interaction Database)MPP5
DoCM (Curated mutations)MPP5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPP5 (select a term)
intoGenMPP5
Cancer3DMPP5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606958   
Orphanet
MedgenMPP5
Genetic Testing Registry MPP5
NextProtQ8N3R9 [Medical]
TSGene64398
GENETestsMPP5
Huge Navigator MPP5 [HugePedia]
snp3D : Map Gene to Disease64398
BioCentury BCIQMPP5
ClinGenMPP5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64398
Chemical/Pharm GKB GenePA38631
Clinical trialMPP5
Miscellaneous
canSAR (ICR)MPP5 (select the gene name)
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPP5
EVEXMPP5
GoPubMedMPP5
iHOPMPP5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:10:59 CEST 2017

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