Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MPPED2 (metallophosphoesterase domain containing 2)

Identity

Alias_namesC11orf8
chromosome 11 open reading frame 8
Alias_symbol (synonym)239FB
D11S302E
Hs.46638
FAM1B
dJ873F21.1
dJ1024C24.1
Other alias
HGNC (Hugo) MPPED2
LocusID (NCBI) 744
Atlas_Id 52878
Location 11p14.1  [Link to chromosome band 11p14]
Location_base_pair Starts at 30410071 and ends at 30580493 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EIF3M (11p13) / MPPED2 (11p14.1)MPPED2 (11p14.1) / AMOTL1 (11q21)MPPED2 (11p14.1) / MAP1S (19p13.11)
MPPED2 11p14.1 / AMOTL1 11q21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(11;11)(p14;p13) EIF3M/MPPED2
t(11;11)(p14;q21) MPPED2/AMOTL1


External links

Nomenclature
HGNC (Hugo)MPPED2   1180
Cards
Entrez_Gene (NCBI)MPPED2  744  metallophosphoesterase domain containing 2
Aliases239FB; C11orf8
GeneCards (Weizmann)MPPED2
Ensembl hg19 (Hinxton)ENSG00000066382 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000066382 [Gene_View]  ENSG00000066382 [Sequence]  chr11:30410071-30580493 [Contig_View]  MPPED2 [Vega]
ICGC DataPortalENSG00000066382
TCGA cBioPortalMPPED2
AceView (NCBI)MPPED2
Genatlas (Paris)MPPED2
WikiGenes744
SOURCE (Princeton)MPPED2
Genetics Home Reference (NIH)MPPED2
Genomic and cartography
GoldenPath hg38 (UCSC)MPPED2  -     chr11:30410071-30580493 -  11p14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPPED2  -     11p14.1   [Description]    (hg19-Feb_2009)
EnsemblMPPED2 - 11p14.1 [CytoView hg19]  MPPED2 - 11p14.1 [CytoView hg38]
Mapping of homologs : NCBIMPPED2 [Mapview hg19]  MPPED2 [Mapview hg38]
OMIM600911   
Gene and transcription
Genbank (Entrez)AA020012 AA916486 AB209163 AK309809 AK314833
RefSeq transcript (Entrez)NM_001145399 NM_001584
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPPED2
Cluster EST : UnigeneHs.289795 [ NCBI ]
CGAP (NCI)Hs.289795
Alternative Splicing GalleryENSG00000066382
Gene ExpressionMPPED2 [ NCBI-GEO ]   MPPED2 [ EBI - ARRAY_EXPRESS ]   MPPED2 [ SEEK ]   MPPED2 [ MEM ]
Gene Expression Viewer (FireBrowse)MPPED2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)744
GTEX Portal (Tissue expression)MPPED2
Human Protein AtlasENSG00000066382-MPPED2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15777   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15777  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15777
Splice isoforms : SwissVarQ15777
Catalytic activity : Enzyme3.1.-.- [ Enzyme-Expasy ]   3.1.-.-3.1.-.- [ IntEnz-EBI ]   3.1.-.- [ BRENDA ]   3.1.-.- [ KEGG ]   
PhosPhoSitePlusQ15777
Domains : Interpro (EBI)Calcineurin-like_Pesterase    Calcineurin-like_PHP_ApaH    Metallo-depent_PP-like   
Domain families : Pfam (Sanger)Metallophos (PF00149)   
Domain families : Pfam (NCBI)pfam00149   
Conserved Domain (NCBI)MPPED2
DMDM Disease mutations744
Blocks (Seattle)MPPED2
SuperfamilyQ15777
Human Protein Atlas [tissue]ENSG00000066382-MPPED2 [tissue]
Peptide AtlasQ15777
HPRD02947
IPIIPI00019521   IPI00607734   IPI00982876   IPI00977320   
Protein Interaction databases
DIP (DOE-UCLA)Q15777
IntAct (EBI)Q15777
FunCoupENSG00000066382
BioGRIDMPPED2
STRING (EMBL)MPPED2
ZODIACMPPED2
Ontologies - Pathways
QuickGOQ15777
Ontology : AmiGOprotein binding  nervous system development  hydrolase activity  metal ion binding  
Ontology : EGO-EBIprotein binding  nervous system development  hydrolase activity  metal ion binding  
NDEx NetworkMPPED2
Atlas of Cancer Signalling NetworkMPPED2
Wikipedia pathwaysMPPED2
Orthology - Evolution
OrthoDB744
GeneTree (enSembl)ENSG00000066382
Phylogenetic Trees/Animal Genes : TreeFamMPPED2
HOVERGENQ15777
HOGENOMQ15777
Homologs : HomoloGeneMPPED2
Homology/Alignments : Family Browser (UCSC)MPPED2
Gene fusions - Rearrangements
Fusion : MitelmanEIF3M/MPPED2 [11p13/11p14.1]  [t(11;11)(p13;p14)]  
Fusion : MitelmanMPPED2/AMOTL1 [11p14.1/11q21]  [t(11;11)(p14;q21)]  
Fusion PortalMPPED2 11p14.1 AMOTL1 11q21 LGG
Fusion : QuiverMPPED2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPPED2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPPED2
dbVarMPPED2
ClinVarMPPED2
1000_GenomesMPPED2 
Exome Variant ServerMPPED2
ExAC (Exome Aggregation Consortium)ENSG00000066382
GNOMAD BrowserENSG00000066382
Varsome BrowserMPPED2
Genetic variants : HAPMAP744
Genomic Variants (DGV)MPPED2 [DGVbeta]
DECIPHERMPPED2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMPPED2 
Mutations
ICGC Data PortalMPPED2 
TCGA Data PortalMPPED2 
Broad Tumor PortalMPPED2
OASIS PortalMPPED2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMPPED2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMPPED2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MPPED2
DgiDB (Drug Gene Interaction Database)MPPED2
DoCM (Curated mutations)MPPED2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPPED2 (select a term)
intoGenMPPED2
Cancer3DMPPED2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600911   
Orphanet
DisGeNETMPPED2
MedgenMPPED2
Genetic Testing Registry MPPED2
NextProtQ15777 [Medical]
TSGene744
GENETestsMPPED2
Target ValidationMPPED2
Huge Navigator MPPED2 [HugePedia]
snp3D : Map Gene to Disease744
BioCentury BCIQMPPED2
ClinGenMPPED2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD744
Chemical/Pharm GKB GenePA25499
Clinical trialMPPED2
Miscellaneous
canSAR (ICR)MPPED2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPPED2
EVEXMPPED2
GoPubMedMPPED2
iHOPMPPED2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:38:36 CEST 2018

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.