Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MPZ (myelin protein zero)

Identity

Alias_namesCMT1
CMT1B
Charcot-Marie-Tooth neuropathy 1B
Alias_symbol (synonym)HMSNIB
CMT2I
CMT2J
Other aliasCHM
CMT4E
CMTDI3
CMTDID
DSS
MPP
P0
HGNC (Hugo) MPZ
LocusID (NCBI) 4359
Atlas_Id 70401
Location 1q23.3  [Link to chromosome band 1q23]
Location_base_pair Starts at 161304735 and ends at 161309972 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MPZ   7225
LRG (Locus Reference Genomic)LRG_256
Cards
Entrez_Gene (NCBI)MPZ  4359  myelin protein zero
AliasesCHM; CMT1; CMT1B; CMT2I; 
CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; P0
GeneCards (Weizmann)MPZ
Ensembl hg19 (Hinxton)ENSG00000158887 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158887 [Gene_View]  chr1:161304735-161309972 [Contig_View]  MPZ [Vega]
ICGC DataPortalENSG00000158887
TCGA cBioPortalMPZ
AceView (NCBI)MPZ
Genatlas (Paris)MPZ
WikiGenes4359
SOURCE (Princeton)MPZ
Genetics Home Reference (NIH)MPZ
Genomic and cartography
GoldenPath hg38 (UCSC)MPZ  -     chr1:161304735-161309972 -  1q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPZ  -     1q23.3   [Description]    (hg19-Feb_2009)
EnsemblMPZ - 1q23.3 [CytoView hg19]  MPZ - 1q23.3 [CytoView hg38]
Mapping of homologs : NCBIMPZ [Mapview hg19]  MPZ [Mapview hg38]
OMIM118200   145900   159440   180800   605253   607677   607736   607791   
Gene and transcription
Genbank (Entrez)AK313555 BC006491 BF509916 BM663255 BT006765
RefSeq transcript (Entrez)NM_000530 NM_001315491
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPZ
Cluster EST : UnigeneHs.591486 [ NCBI ]
CGAP (NCI)Hs.591486
Alternative Splicing GalleryENSG00000158887
Gene ExpressionMPZ [ NCBI-GEO ]   MPZ [ EBI - ARRAY_EXPRESS ]   MPZ [ SEEK ]   MPZ [ MEM ]
Gene Expression Viewer (FireBrowse)MPZ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4359
GTEX Portal (Tissue expression)MPZ
Human Protein AtlasENSG00000158887-MPZ [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25189   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25189  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25189
Splice isoforms : SwissVarP25189
PhosPhoSitePlusP25189
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)    MYELIN_P0 (PS00568)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_fold    Ig_sub    Ig_V-set    Myelin-PO_C    Myelin_P0-rel    Myelin_P0_CS    P0   
Domain families : Pfam (Sanger)Myelin-PO_C (PF10570)    V-set (PF07686)   
Domain families : Pfam (NCBI)pfam10570    pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGv (SM00406)  
Conserved Domain (NCBI)MPZ
DMDM Disease mutations4359
Blocks (Seattle)MPZ
PDB (SRS)1N2P    3OAI   
PDB (PDBSum)1N2P    3OAI   
PDB (IMB)1N2P    3OAI   
PDB (RSDB)1N2P    3OAI   
Structural Biology KnowledgeBase1N2P    3OAI   
SCOP (Structural Classification of Proteins)1N2P    3OAI   
CATH (Classification of proteins structures)1N2P    3OAI   
SuperfamilyP25189
Human Protein Atlas [tissue]ENSG00000158887-MPZ [tissue]
Peptide AtlasP25189
HPRD01159
IPIIPI00844448   IPI00478921   IPI00976050   
Protein Interaction databases
DIP (DOE-UCLA)P25189
IntAct (EBI)P25189
FunCoupENSG00000158887
BioGRIDMPZ
STRING (EMBL)MPZ
ZODIACMPZ
Ontologies - Pathways
QuickGOP25189
Ontology : AmiGOstructural molecule activity  lysosome  rough endoplasmic reticulum  plasma membrane  integral component of plasma membrane  chemical synaptic transmission  basolateral plasma membrane  myelination  negative regulation of apoptotic process  myelin sheath  cell-cell adhesion via plasma-membrane adhesion molecules  cell aggregation  
Ontology : EGO-EBIstructural molecule activity  lysosome  rough endoplasmic reticulum  plasma membrane  integral component of plasma membrane  chemical synaptic transmission  basolateral plasma membrane  myelination  negative regulation of apoptotic process  myelin sheath  cell-cell adhesion via plasma-membrane adhesion molecules  cell aggregation  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkMPZ
Atlas of Cancer Signalling NetworkMPZ
Wikipedia pathwaysMPZ
Orthology - Evolution
OrthoDB4359
GeneTree (enSembl)ENSG00000158887
Phylogenetic Trees/Animal Genes : TreeFamMPZ
HOVERGENP25189
HOGENOMP25189
Homologs : HomoloGeneMPZ
Homology/Alignments : Family Browser (UCSC)MPZ
Gene fusions - Rearrangements
Tumor Fusion PortalMPZ
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPZ
dbVarMPZ
ClinVarMPZ
1000_GenomesMPZ 
Exome Variant ServerMPZ
ExAC (Exome Aggregation Consortium)ENSG00000158887
GNOMAD BrowserENSG00000158887
Genetic variants : HAPMAP4359
Genomic Variants (DGV)MPZ [DGVbeta]
DECIPHERMPZ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMPZ 
Mutations
ICGC Data PortalMPZ 
TCGA Data PortalMPZ 
Broad Tumor PortalMPZ
OASIS PortalMPZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMPZ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMPZ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)SpainMDB
BioMutasearch MPZ
DgiDB (Drug Gene Interaction Database)MPZ
DoCM (Curated mutations)MPZ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPZ (select a term)
intoGenMPZ
Cancer3DMPZ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM118200    145900    159440    180800    605253    607677    607736    607791   
Orphanet2789    21789    10852    14793    14619    14515    14516   
DisGeNETMPZ
MedgenMPZ
Genetic Testing Registry MPZ
NextProtP25189 [Medical]
TSGene4359
GENETestsMPZ
Target ValidationMPZ
Huge Navigator MPZ [HugePedia]
snp3D : Map Gene to Disease4359
BioCentury BCIQMPZ
ClinGenMPZ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4359
Chemical/Pharm GKB GenePA30930
Clinical trialMPZ
Miscellaneous
canSAR (ICR)MPZ (select the gene name)
Probes
Litterature
PubMed146 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPZ
EVEXMPZ
GoPubMedMPZ
iHOPMPZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Nov 20 20:01:53 CET 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.