Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MPZL1 (myelin protein zero like 1)

Identity

Alias_symbol (synonym)PZR
FLJ21047
Other aliasMPZL1b
PZR1b
PZRa
PZRb
HGNC (Hugo) MPZL1
LocusID (NCBI) 9019
Atlas_Id 54902
Location 1q24.2  [Link to chromosome band 1q24]
Location_base_pair Starts at 167721950 and ends at 167791919 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DCAF6 (1q24.2) / MPZL1 (1q24.2)MPZL1 (1q24.2) / MPZL1 (1q24.2)MPZL1 (1q24.2) / PDE4DIP (1q21.1)
MPZL1 (1q24.2) / UCK2 (1q24.1)DCAF6 1q24.2 / MPZL1 1q24.2MPZL1 1q24.2 / PDE4DIP 1q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(1;1)(q21;q24) MPZL1/PDE4DIP
DCAF6/MPZL1 (1q24)
DCAF6/MPZL1 (1q24)


External links

Nomenclature
HGNC (Hugo)MPZL1   7226
Cards
Entrez_Gene (NCBI)MPZL1  9019  myelin protein zero like 1
AliasesMPZL1b; PZR; PZR1b; PZRa; 
PZRb
GeneCards (Weizmann)MPZL1
Ensembl hg19 (Hinxton)ENSG00000197965 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197965 [Gene_View]  ENSG00000197965 [Sequence]  chr1:167721950-167791919 [Contig_View]  MPZL1 [Vega]
ICGC DataPortalENSG00000197965
TCGA cBioPortalMPZL1
AceView (NCBI)MPZL1
Genatlas (Paris)MPZL1
WikiGenes9019
SOURCE (Princeton)MPZL1
Genetics Home Reference (NIH)MPZL1
Genomic and cartography
GoldenPath hg38 (UCSC)MPZL1  -     chr1:167721950-167791919 +  1q24.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPZL1  -     1q24.2   [Description]    (hg19-Feb_2009)
EnsemblMPZL1 - 1q24.2 [CytoView hg19]  MPZL1 - 1q24.2 [CytoView hg38]
Mapping of homologs : NCBIMPZL1 [Mapview hg19]  MPZL1 [Mapview hg38]
OMIM604376   
Gene and transcription
Genbank (Entrez)AF087020 AF092424 AF092425 AF095726 AF095727
RefSeq transcript (Entrez)NM_001146191 NM_003953 NM_024569
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPZL1
Cluster EST : UnigeneHs.493919 [ NCBI ]
CGAP (NCI)Hs.493919
Alternative Splicing GalleryENSG00000197965
Gene ExpressionMPZL1 [ NCBI-GEO ]   MPZL1 [ EBI - ARRAY_EXPRESS ]   MPZL1 [ SEEK ]   MPZL1 [ MEM ]
Gene Expression Viewer (FireBrowse)MPZL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9019
GTEX Portal (Tissue expression)MPZL1
Human Protein AtlasENSG00000197965-MPZL1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95297   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95297  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95297
Splice isoforms : SwissVarO95297
PhosPhoSitePlusO95297
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set    MPZL1    Myelin_P0-rel   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGv (SM00406)  
Conserved Domain (NCBI)MPZL1
DMDM Disease mutations9019
Blocks (Seattle)MPZL1
SuperfamilyO95297
Human Protein Atlas [tissue]ENSG00000197965-MPZL1 [tissue]
Peptide AtlasO95297
HPRD05086
IPIIPI00022558   IPI00760547   IPI00410607   IPI00644618   IPI00893925   IPI00893553   IPI00893201   
Protein Interaction databases
DIP (DOE-UCLA)O95297
IntAct (EBI)O95297
FunCoupENSG00000197965
BioGRIDMPZL1
STRING (EMBL)MPZL1
ZODIACMPZL1
Ontologies - Pathways
QuickGOO95297
Ontology : AmiGOstructural molecule activity  protein binding  integral component of plasma membrane  focal adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  cell-cell signaling  cell surface  
Ontology : EGO-EBIstructural molecule activity  protein binding  integral component of plasma membrane  focal adhesion  transmembrane receptor protein tyrosine kinase signaling pathway  cell-cell signaling  cell surface  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkMPZL1
Atlas of Cancer Signalling NetworkMPZL1
Wikipedia pathwaysMPZL1
Orthology - Evolution
OrthoDB9019
GeneTree (enSembl)ENSG00000197965
Phylogenetic Trees/Animal Genes : TreeFamMPZL1
HOVERGENO95297
HOGENOMO95297
Homologs : HomoloGeneMPZL1
Homology/Alignments : Family Browser (UCSC)MPZL1
Gene fusions - Rearrangements
Fusion : MitelmanDCAF6/MPZL1 [1q24.2/1q24.2]  [t(1;1)(q24;q24)]  
Fusion : MitelmanMPZL1/PDE4DIP [1q24.2/1q21.1]  [t(1;1)(q21;q24)]  
Fusion PortalDCAF6 1q24.2 MPZL1 1q24.2 BRCA
Fusion PortalMPZL1 1q24.2 PDE4DIP 1q21.1 BRCA
Fusion : QuiverMPZL1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPZL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPZL1
dbVarMPZL1
ClinVarMPZL1
1000_GenomesMPZL1 
Exome Variant ServerMPZL1
ExAC (Exome Aggregation Consortium)ENSG00000197965
GNOMAD BrowserENSG00000197965
Varsome BrowserMPZL1
Genetic variants : HAPMAP9019
Genomic Variants (DGV)MPZL1 [DGVbeta]
DECIPHERMPZL1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMPZL1 
Mutations
ICGC Data PortalMPZL1 
TCGA Data PortalMPZL1 
Broad Tumor PortalMPZL1
OASIS PortalMPZL1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMPZL1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMPZL1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MPZL1
DgiDB (Drug Gene Interaction Database)MPZL1
DoCM (Curated mutations)MPZL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPZL1 (select a term)
intoGenMPZL1
Cancer3DMPZL1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604376   
Orphanet
DisGeNETMPZL1
MedgenMPZL1
Genetic Testing Registry MPZL1
NextProtO95297 [Medical]
TSGene9019
GENETestsMPZL1
Target ValidationMPZL1
Huge Navigator MPZL1 [HugePedia]
snp3D : Map Gene to Disease9019
BioCentury BCIQMPZL1
ClinGenMPZL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9019
Chemical/Pharm GKB GenePA30931
Clinical trialMPZL1
Miscellaneous
canSAR (ICR)MPZL1 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPZL1
EVEXMPZL1
GoPubMedMPZL1
iHOPMPZL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Aug 27 11:38:37 CEST 2018

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