Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MPZL2 (myelin protein zero like 2)

Identity

Alias_namesEVA1
epithelial V-like antigen 1
Alias_symbol (synonym)EVA
Other aliasDFNB111
HGNC (Hugo) MPZL2
LocusID (NCBI) 10205
Atlas_Id 56516
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 118256911 and ends at 118264536 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRISPLD2 (16q24.1) / MPZL2 (11q23.3)DSCAML1 (11q23.3) / MPZL2 (11q23.3)MPZL3 (11q23.3) / MPZL2 (11q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  DSCAML1/MPZL2 (11q23)
t(11;16)(q23;q24) CRISPLD2/MPZL2

External links

Nomenclature
HGNC (Hugo)MPZL2   3496
Cards
Entrez_Gene (NCBI)MPZL2  10205  myelin protein zero like 2
AliasesDFNB111; EVA; EVA1
GeneCards (Weizmann)MPZL2
Ensembl hg19 (Hinxton)ENSG00000149573 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149573 [Gene_View]  ENSG00000149573 [Sequence]  chr11:118256911-118264536 [Contig_View]  MPZL2 [Vega]
ICGC DataPortalENSG00000149573
TCGA cBioPortalMPZL2
AceView (NCBI)MPZL2
Genatlas (Paris)MPZL2
WikiGenes10205
SOURCE (Princeton)MPZL2
Genetics Home Reference (NIH)MPZL2
Genomic and cartography
GoldenPath hg38 (UCSC)MPZL2  -     chr11:118256911-118264536 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MPZL2  -     11q23.3   [Description]    (hg19-Feb_2009)
MPZL2 - 11q23.3 [CytoView hg19]  MPZL2 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIMPZL2 [Mapview hg19]  MPZL2 [Mapview hg38]
OMIM604873   618145   
Gene and transcription
Genbank (Entrez)AF030455 AF275945 AF304447 AK290326 AW073724
RefSeq transcript (Entrez)NM_005797 NM_144765
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MPZL2
Cluster EST : UnigeneHs.116651 [ NCBI ]
CGAP (NCI)Hs.116651
Alternative Splicing GalleryENSG00000149573
Gene ExpressionMPZL2 [ NCBI-GEO ]   MPZL2 [ EBI - ARRAY_EXPRESS ]   MPZL2 [ SEEK ]   MPZL2 [ MEM ]
Gene Expression Viewer (FireBrowse)MPZL2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10205
GTEX Portal (Tissue expression)MPZL2
Human Protein AtlasENSG00000149573-MPZL2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60487   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60487  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60487
Splice isoforms : SwissVarO60487
PhosPhoSitePlusO60487
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub    Ig_V-set    MPZL2    Myelin_P0-rel   
Domain families : Pfam (Sanger)V-set (PF07686)   
Domain families : Pfam (NCBI)pfam07686   
Domain families : Smart (EMBL)IG (SM00409)  IGv (SM00406)  
Conserved Domain (NCBI)MPZL2
DMDM Disease mutations10205
Blocks (Seattle)MPZL2
SuperfamilyO60487
Human Protein Atlas [tissue]ENSG00000149573-MPZL2 [tissue]
Peptide AtlasO60487
HPRD05340
IPIIPI00024811   
Protein Interaction databases
DIP (DOE-UCLA)O60487
IntAct (EBI)O60487
FunCoupENSG00000149573
BioGRIDMPZL2
STRING (EMBL)MPZL2
ZODIACMPZL2
Ontologies - Pathways
QuickGOO60487
Ontology : AmiGOprotein binding  cytoskeleton  homophilic cell adhesion via plasma membrane adhesion molecules  anatomical structure morphogenesis  integral component of membrane  
Ontology : EGO-EBIprotein binding  cytoskeleton  homophilic cell adhesion via plasma membrane adhesion molecules  anatomical structure morphogenesis  integral component of membrane  
NDEx NetworkMPZL2
Atlas of Cancer Signalling NetworkMPZL2
Wikipedia pathwaysMPZL2
Orthology - Evolution
OrthoDB10205
GeneTree (enSembl)ENSG00000149573
Phylogenetic Trees/Animal Genes : TreeFamMPZL2
HOGENOMO60487
Homologs : HomoloGeneMPZL2
Homology/Alignments : Family Browser (UCSC)MPZL2
Gene fusions - Rearrangements
Fusion : QuiverMPZL2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMPZL2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MPZL2
dbVarMPZL2
ClinVarMPZL2
1000_GenomesMPZL2 
Exome Variant ServerMPZL2
ExAC (Exome Aggregation Consortium)ENSG00000149573
GNOMAD BrowserENSG00000149573
Varsome BrowserMPZL2
Genetic variants : HAPMAP10205
Genomic Variants (DGV)MPZL2 [DGVbeta]
DECIPHERMPZL2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMPZL2 
Mutations
ICGC Data PortalMPZL2 
TCGA Data PortalMPZL2 
Broad Tumor PortalMPZL2
OASIS PortalMPZL2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMPZL2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMPZL2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MPZL2
DgiDB (Drug Gene Interaction Database)MPZL2
DoCM (Curated mutations)MPZL2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MPZL2 (select a term)
intoGenMPZL2
Cancer3DMPZL2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604873    618145   
Orphanet
DisGeNETMPZL2
MedgenMPZL2
Genetic Testing Registry MPZL2
NextProtO60487 [Medical]
TSGene10205
GENETestsMPZL2
Target ValidationMPZL2
Huge Navigator MPZL2 [HugePedia]
snp3D : Map Gene to Disease10205
BioCentury BCIQMPZL2
ClinGenMPZL2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10205
Chemical/Pharm GKB GenePA162396145
Clinical trialMPZL2
Miscellaneous
canSAR (ICR)MPZL2 (select the gene name)
DataMed IndexMPZL2
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMPZL2
EVEXMPZL2
GoPubMedMPZL2
iHOPMPZL2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 21 15:58:23 CET 2019
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