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MRAP (melanocortin 2 receptor accessory protein)

Identity

Alias (NCBI)B27
C21orf61
FALP
FGD2
GCCD2
HGNC (Hugo) MRAP
HGNC Alias symbB27
FALP
HGNC Previous nameC21orf61
HGNC Previous namechromosome 21 open reading frame 61
LocusID (NCBI) 56246
Atlas_Id 56104
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 32291813 and ends at 32314783 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AC006465.3 () / MRAP (21q22.11)EVA1C (21q22.11) / MRAP (21q22.11)MRAP (21q22.11) / SMC2 (9q31.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MRAP   1304
Cards
Entrez_Gene (NCBI)MRAP    melanocortin 2 receptor accessory protein
AliasesB27; C21orf61; FALP; FGD2; 
GCCD2
GeneCards (Weizmann)MRAP
Ensembl hg19 (Hinxton)ENSG00000170262 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170262 [Gene_View]  ENSG00000170262 [Sequence]  chr21:32291813-32314783 [Contig_View]  MRAP [Vega]
ICGC DataPortalENSG00000170262
TCGA cBioPortalMRAP
AceView (NCBI)MRAP
Genatlas (Paris)MRAP
SOURCE (Princeton)MRAP
Genetics Home Reference (NIH)MRAP
Genomic and cartography
GoldenPath hg38 (UCSC)MRAP  -     chr21:32291813-32314783 +  21q22.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRAP  -     21q22.11   [Description]    (hg19-Feb_2009)
GoldenPathMRAP - 21q22.11 [CytoView hg19]  MRAP - 21q22.11 [CytoView hg38]
ImmunoBaseENSG00000170262
Genome Data Viewer NCBIMRAP [Mapview hg19]  
OMIM607398   609196   
Gene and transcription
Genbank (Entrez)AF454915 AF454916 AF483549 AY079152 BC062721
RefSeq transcript (Entrez)NM_001285394 NM_001379228 NM_178817 NM_206898
Consensus coding sequences : CCDS (NCBI)MRAP
Gene ExpressionMRAP [ NCBI-GEO ]   MRAP [ EBI - ARRAY_EXPRESS ]   MRAP [ SEEK ]   MRAP [ MEM ]
Gene Expression Viewer (FireBrowse)MRAP [ Firebrowse - Broad ]
GenevisibleExpression of MRAP in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56246
GTEX Portal (Tissue expression)MRAP
Human Protein AtlasENSG00000170262-MRAP [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TCY5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TCY5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TCY5
PhosPhoSitePlusQ8TCY5
Domains : Interpro (EBI)MRAP   
Domain families : Pfam (Sanger)MRAP (PF15183)   
Domain families : Pfam (NCBI)pfam15183   
Conserved Domain (NCBI)MRAP
SuperfamilyQ8TCY5
AlphaFold pdb e-kbQ8TCY5   
Human Protein Atlas [tissue]ENSG00000170262-MRAP [tissue]
HPRD10758
Protein Interaction databases
DIP (DOE-UCLA)Q8TCY5
IntAct (EBI)Q8TCY5
BioGRIDMRAP
STRING (EMBL)MRAP
ZODIACMRAP
Ontologies - Pathways
QuickGOQ8TCY5
Ontology : AmiGOprotein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of membrane  signaling receptor regulator activity  corticotropin hormone receptor binding  corticotropin hormone receptor binding  type 3 melanocortin receptor binding  type 3 melanocortin receptor binding  type 4 melanocortin receptor binding  type 4 melanocortin receptor binding  type 5 melanocortin receptor binding  type 5 melanocortin receptor binding  identical protein binding  intracellular membrane-bounded organelle  type 1 melanocortin receptor binding  type 1 melanocortin receptor binding  protein localization to plasma membrane  protein localization to plasma membrane  regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  negative regulation of protein localization to plasma membrane  
Ontology : EGO-EBIprotein binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  plasma membrane  plasma membrane  integral component of membrane  signaling receptor regulator activity  corticotropin hormone receptor binding  corticotropin hormone receptor binding  type 3 melanocortin receptor binding  type 3 melanocortin receptor binding  type 4 melanocortin receptor binding  type 4 melanocortin receptor binding  type 5 melanocortin receptor binding  type 5 melanocortin receptor binding  identical protein binding  intracellular membrane-bounded organelle  type 1 melanocortin receptor binding  type 1 melanocortin receptor binding  protein localization to plasma membrane  protein localization to plasma membrane  regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  negative regulation of protein localization to plasma membrane  
NDEx NetworkMRAP
Atlas of Cancer Signalling NetworkMRAP
Wikipedia pathwaysMRAP
Orthology - Evolution
OrthoDB56246
GeneTree (enSembl)ENSG00000170262
Phylogenetic Trees/Animal Genes : TreeFamMRAP
Homologs : HomoloGeneMRAP
Homology/Alignments : Family Browser (UCSC)MRAP
Gene fusions - Rearrangements
Fusion : QuiverMRAP
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRAP
dbVarMRAP
ClinVarMRAP
MonarchMRAP
1000_GenomesMRAP 
Exome Variant ServerMRAP
GNOMAD BrowserENSG00000170262
Varsome BrowserMRAP
ACMGMRAP variants
VarityQ8TCY5
Genomic Variants (DGV)MRAP [DGVbeta]
DECIPHERMRAP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRAP 
Mutations
ICGC Data PortalMRAP 
TCGA Data PortalMRAP 
Broad Tumor PortalMRAP
OASIS PortalMRAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRAP  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMRAP
Mutations and Diseases : HGMDMRAP
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMRAP
DgiDB (Drug Gene Interaction Database)MRAP
DoCM (Curated mutations)MRAP
CIViC (Clinical Interpretations of Variants in Cancer)MRAP
Cancer3DMRAP
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607398    609196   
Orphanet3506   
DisGeNETMRAP
MedgenMRAP
Genetic Testing Registry MRAP
NextProtQ8TCY5 [Medical]
GENETestsMRAP
Target ValidationMRAP
Huge Navigator MRAP [HugePedia]
ClinGenMRAP
Clinical trials, drugs, therapy
MyCancerGenomeMRAP
Protein Interactions : CTDMRAP
Pharm GKB GenePA25856
PharosQ8TCY5
Clinical trialMRAP
Miscellaneous
canSAR (ICR)MRAP
HarmonizomeMRAP
DataMed IndexMRAP
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMRAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:21:14 CEST 2021

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