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MRI1 (methylthioribose-1-phosphate isomerase 1)

Identity

Alias (NCBI)M1Pi
MRDI
MTNA
Ypr118w
HGNC (Hugo) MRI1
HGNC Alias symbMGC3207
Ypr118w
mtnA
MRDI
HGNC Alias namemediator of RhoA-dependent invasion
 S-methyl-5-thioribose-1-phosphate isomerase 1
HGNC Previous namemethylthioribose-1-phosphate isomerase homolog (S. cerevisiae)
LocusID (NCBI) 84245
Atlas_Id 70418
Location 19p13.13  [Link to chromosome band 19p13]
Location_base_pair Starts at 13764514 and ends at 13774282 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MRI1   28469
Cards
Entrez_Gene (NCBI)MRI1  84245  methylthioribose-1-phosphate isomerase 1
AliasesM1Pi; MRDI; MTNA; Ypr118w
GeneCards (Weizmann)MRI1
Ensembl hg19 (Hinxton)ENSG00000037757 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000037757 [Gene_View]  ENSG00000037757 [Sequence]  chr19:13764514-13774282 [Contig_View]  MRI1 [Vega]
ICGC DataPortalENSG00000037757
TCGA cBioPortalMRI1
AceView (NCBI)MRI1
Genatlas (Paris)MRI1
WikiGenes84245
SOURCE (Princeton)MRI1
Genetics Home Reference (NIH)MRI1
Genomic and cartography
GoldenPath hg38 (UCSC)MRI1  -     chr19:13764514-13774282 +  19p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRI1  -     19p13.13   [Description]    (hg19-Feb_2009)
GoldenPathMRI1 - 19p13.13 [CytoView hg19]  MRI1 - 19p13.13 [CytoView hg38]
ImmunoBaseENSG00000037757
genome Data Viewer NCBIMRI1 [Mapview hg19]  
OMIM615105   
Gene and transcription
Genbank (Entrez)AF318324 AL834276 AY358176 BC001703 BM147362
RefSeq transcript (Entrez)NM_001031727 NM_001329572 NM_032285
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MRI1
Alternative Splicing GalleryENSG00000037757
Gene ExpressionMRI1 [ NCBI-GEO ]   MRI1 [ EBI - ARRAY_EXPRESS ]   MRI1 [ SEEK ]   MRI1 [ MEM ]
Gene Expression Viewer (FireBrowse)MRI1 [ Firebrowse - Broad ]
GenevisibleExpression of MRI1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84245
GTEX Portal (Tissue expression)MRI1
Human Protein AtlasENSG00000037757-MRI1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BV20   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BV20  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BV20
Splice isoforms : SwissVarQ9BV20
PhosPhoSitePlusQ9BV20
Domains : Interpro (EBI)IF-2B-related    IF-M1Pi    IF_2B-like_C    Initiation_fac_2B_a/b/d    M1Pi_N    NagB/RpiA_transferase-like   
Domain families : Pfam (Sanger)IF-2B (PF01008)   
Domain families : Pfam (NCBI)pfam01008   
Conserved Domain (NCBI)MRI1
DMDM Disease mutations84245
Blocks (Seattle)MRI1
PDB (RSDB)4LDQ    4LDR   
PDB Europe4LDQ    4LDR   
PDB (PDBSum)4LDQ    4LDR   
PDB (IMB)4LDQ    4LDR   
Structural Biology KnowledgeBase4LDQ    4LDR   
SCOP (Structural Classification of Proteins)4LDQ    4LDR   
CATH (Classification of proteins structures)4LDQ    4LDR   
SuperfamilyQ9BV20
Human Protein Atlas [tissue]ENSG00000037757-MRI1 [tissue]
Peptide AtlasQ9BV20
HPRD14548
IPIIPI00005948   IPI00184525   IPI00719027   
Protein Interaction databases
DIP (DOE-UCLA)Q9BV20
IntAct (EBI)Q9BV20
FunCoupENSG00000037757
BioGRIDMRI1
STRING (EMBL)MRI1
ZODIACMRI1
Ontologies - Pathways
QuickGOQ9BV20
Ontology : AmiGOfibrillar center  nucleoplasm  cytosol  cytosol  L-methionine salvage from S-adenosylmethionine  L-methionine salvage from methylthioadenosine  L-methionine salvage from methylthioadenosine  L-methionine salvage from methylthioadenosine  identical protein binding  cell projection  S-methyl-5-thioribose-1-phosphate isomerase activity  S-methyl-5-thioribose-1-phosphate isomerase activity  
Ontology : EGO-EBIfibrillar center  nucleoplasm  cytosol  cytosol  L-methionine salvage from S-adenosylmethionine  L-methionine salvage from methylthioadenosine  L-methionine salvage from methylthioadenosine  L-methionine salvage from methylthioadenosine  identical protein binding  cell projection  S-methyl-5-thioribose-1-phosphate isomerase activity  S-methyl-5-thioribose-1-phosphate isomerase activity  
NDEx NetworkMRI1
Atlas of Cancer Signalling NetworkMRI1
Wikipedia pathwaysMRI1
Orthology - Evolution
OrthoDB84245
GeneTree (enSembl)ENSG00000037757
Phylogenetic Trees/Animal Genes : TreeFamMRI1
HOGENOMQ9BV20
Homologs : HomoloGeneMRI1
Homology/Alignments : Family Browser (UCSC)MRI1
Gene fusions - Rearrangements
Fusion : QuiverMRI1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRI1
dbVarMRI1
ClinVarMRI1
1000_GenomesMRI1 
Exome Variant ServerMRI1
GNOMAD BrowserENSG00000037757
Varsome BrowserMRI1
Genetic variants : HAPMAP84245
Genomic Variants (DGV)MRI1 [DGVbeta]
DECIPHERMRI1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRI1 
Mutations
ICGC Data PortalMRI1 
TCGA Data PortalMRI1 
Broad Tumor PortalMRI1
OASIS PortalMRI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRI1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMRI1
Mutations and Diseases : HGMDMRI1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MRI1
DgiDB (Drug Gene Interaction Database)MRI1
DoCM (Curated mutations)MRI1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MRI1 (select a term)
intoGenMRI1
Cancer3DMRI1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615105   
Orphanet
DisGeNETMRI1
MedgenMRI1
Genetic Testing Registry MRI1
NextProtQ9BV20 [Medical]
TSGene84245
GENETestsMRI1
Target ValidationMRI1
Huge Navigator MRI1 [HugePedia]
snp3D : Map Gene to Disease84245
BioCentury BCIQMRI1
ClinGenMRI1
Clinical trials, drugs, therapy
Protein Interactions : CTD84245
Pharm GKB GenePA164723110
Clinical trialMRI1
Miscellaneous
canSAR (ICR)MRI1 (select the gene name)
HarmonizomeMRI1
DataMed IndexMRI1
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMRI1
EVEXMRI1
GoPubMedMRI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jul 16 16:18:25 CEST 2020
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