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MRPL14 (mitochondrial ribosomal protein L14)

Identity

Alias_symbol (synonym)RPML32
MRP-L32
Other aliasL14mt
L32mt
MRP-L14
MRPL32
RMPL32
HGNC (Hugo) MRPL14
LocusID (NCBI) 64928
Atlas_Id 70436
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 44113454 and ends at 44127491 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C6 (5p13.1) / MRPL14 (6p21.1)GRINA (8q24.3) / MRPL14 (6p21.1)IRF8 (16q24.1) / MRPL14 (6p21.1)
MGAT5 (2q21.2) / MRPL14 (6p21.1)MRPL14 (6p21.1) / CNPY2 (12q13.3)MRPL14 (6p21.1) / MRPL14 (6p21.1)
MRPL14 (6p21.1) / ZBTB42 (14q32.33)TMEM63B (6p21.1) / MRPL14 (6p21.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p21;p21) TMEM63B/MRPL14


External links

Nomenclature
HGNC (Hugo)MRPL14   14279
Cards
Entrez_Gene (NCBI)MRPL14  64928  mitochondrial ribosomal protein L14
AliasesL14mt; L32mt; MRP-L14; MRP-L32; 
MRPL32; RMPL32; RPML32
GeneCards (Weizmann)MRPL14
Ensembl hg19 (Hinxton)ENSG00000180992 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180992 [Gene_View]  chr6:44113454-44127491 [Contig_View]  MRPL14 [Vega]
ICGC DataPortalENSG00000180992
TCGA cBioPortalMRPL14
AceView (NCBI)MRPL14
Genatlas (Paris)MRPL14
WikiGenes64928
SOURCE (Princeton)MRPL14
Genetics Home Reference (NIH)MRPL14
Genomic and cartography
GoldenPath hg38 (UCSC)MRPL14  -     chr6:44113454-44127491 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRPL14  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblMRPL14 - 6p21.1 [CytoView hg19]  MRPL14 - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIMRPL14 [Mapview hg19]  MRPL14 [Mapview hg38]
OMIM611827   
Gene and transcription
Genbank (Entrez)AA758781 AA887574 AK312086 BC010416 BC065005
RefSeq transcript (Entrez)NM_001318767 NM_001318768 NM_001318769 NM_001318770 NM_001318771 NM_032111
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MRPL14
Cluster EST : UnigeneHs.311190 [ NCBI ]
CGAP (NCI)Hs.311190
Alternative Splicing GalleryENSG00000180992
Gene ExpressionMRPL14 [ NCBI-GEO ]   MRPL14 [ EBI - ARRAY_EXPRESS ]   MRPL14 [ SEEK ]   MRPL14 [ MEM ]
Gene Expression Viewer (FireBrowse)MRPL14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64928
GTEX Portal (Tissue expression)MRPL14
Human Protein AtlasENSG00000180992-MRPL14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6P1L8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6P1L8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6P1L8
Splice isoforms : SwissVarQ6P1L8
PhosPhoSitePlusQ6P1L8
Domains : Interpro (EBI)Ribosomal_L14P   
Domain families : Pfam (Sanger)Ribosomal_L14 (PF00238)   
Domain families : Pfam (NCBI)pfam00238   
Domain families : Smart (EMBL)Ribosomal_L14 (SM01374)  
Conserved Domain (NCBI)MRPL14
DMDM Disease mutations64928
Blocks (Seattle)MRPL14
PDB (SRS)3J7Y    3J9M   
PDB (PDBSum)3J7Y    3J9M   
PDB (IMB)3J7Y    3J9M   
PDB (RSDB)3J7Y    3J9M   
Structural Biology KnowledgeBase3J7Y    3J9M   
SCOP (Structural Classification of Proteins)3J7Y    3J9M   
CATH (Classification of proteins structures)3J7Y    3J9M   
SuperfamilyQ6P1L8
Human Protein Atlas [tissue]ENSG00000180992-MRPL14 [tissue]
Peptide AtlasQ6P1L8
HPRD14741
IPIIPI00418290   
Protein Interaction databases
DIP (DOE-UCLA)Q6P1L8
IntAct (EBI)Q6P1L8
FunCoupENSG00000180992
BioGRIDMRPL14
STRING (EMBL)MRPL14
ZODIACMRPL14
Ontologies - Pathways
QuickGOQ6P1L8
Ontology : AmiGORNA binding  structural constituent of ribosome  mitochondrion  mitochondrial inner membrane  mitochondrial large ribosomal subunit  mitochondrial translational elongation  mitochondrial translational termination  
Ontology : EGO-EBIRNA binding  structural constituent of ribosome  mitochondrion  mitochondrial inner membrane  mitochondrial large ribosomal subunit  mitochondrial translational elongation  mitochondrial translational termination  
NDEx NetworkMRPL14
Atlas of Cancer Signalling NetworkMRPL14
Wikipedia pathwaysMRPL14
Orthology - Evolution
OrthoDB64928
GeneTree (enSembl)ENSG00000180992
Phylogenetic Trees/Animal Genes : TreeFamMRPL14
HOVERGENQ6P1L8
HOGENOMQ6P1L8
Homologs : HomoloGeneMRPL14
Homology/Alignments : Family Browser (UCSC)MRPL14
Gene fusions - Rearrangements
Fusion : QuiverMRPL14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRPL14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRPL14
dbVarMRPL14
ClinVarMRPL14
1000_GenomesMRPL14 
Exome Variant ServerMRPL14
ExAC (Exome Aggregation Consortium)ENSG00000180992
GNOMAD BrowserENSG00000180992
Genetic variants : HAPMAP64928
Genomic Variants (DGV)MRPL14 [DGVbeta]
DECIPHERMRPL14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRPL14 
Mutations
ICGC Data PortalMRPL14 
TCGA Data PortalMRPL14 
Broad Tumor PortalMRPL14
OASIS PortalMRPL14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRPL14  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMRPL14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MRPL14
DgiDB (Drug Gene Interaction Database)MRPL14
DoCM (Curated mutations)MRPL14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MRPL14 (select a term)
intoGenMRPL14
Cancer3DMRPL14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611827   
Orphanet
DisGeNETMRPL14
MedgenMRPL14
Genetic Testing Registry MRPL14
NextProtQ6P1L8 [Medical]
TSGene64928
GENETestsMRPL14
Target ValidationMRPL14
Huge Navigator MRPL14 [HugePedia]
snp3D : Map Gene to Disease64928
BioCentury BCIQMRPL14
ClinGenMRPL14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64928
Chemical/Pharm GKB GenePA30943
Clinical trialMRPL14
Miscellaneous
canSAR (ICR)MRPL14 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMRPL14
EVEXMRPL14
GoPubMedMRPL14
iHOPMRPL14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 23 18:43:37 CET 2018

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