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MRPL22 (mitochondrial ribosomal protein L22)

Identity

Alias_symbol (synonym)MRP-L25
RPML25
HSPC158
Other aliasL22mt
MRP-L22
HGNC (Hugo) MRPL22
LocusID (NCBI) 29093
Atlas_Id 70445
Location 5q33.2  [Link to chromosome band 5q33]
Location_base_pair Starts at 154941073 and ends at 154969411 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FAM114A2 (5q33.2) / MRPL22 (5q33.2)MRPL22 (5q33.2) / FAM156B (Xp11.22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MRPL22   14480
Cards
Entrez_Gene (NCBI)MRPL22  29093  mitochondrial ribosomal protein L22
AliasesHSPC158; L22mt; MRP-L22; MRP-L25; 
RPML25
GeneCards (Weizmann)MRPL22
Ensembl hg19 (Hinxton)ENSG00000082515 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000082515 [Gene_View]  chr5:154941073-154969411 [Contig_View]  MRPL22 [Vega]
ICGC DataPortalENSG00000082515
TCGA cBioPortalMRPL22
AceView (NCBI)MRPL22
Genatlas (Paris)MRPL22
WikiGenes29093
SOURCE (Princeton)MRPL22
Genetics Home Reference (NIH)MRPL22
Genomic and cartography
GoldenPath hg38 (UCSC)MRPL22  -     chr5:154941073-154969411 +  5q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRPL22  -     5q33.2   [Description]    (hg19-Feb_2009)
EnsemblMRPL22 - 5q33.2 [CytoView hg19]  MRPL22 - 5q33.2 [CytoView hg38]
Mapping of homologs : NCBIMRPL22 [Mapview hg19]  MRPL22 [Mapview hg38]
OMIM611835   
Gene and transcription
Genbank (Entrez)AF161507 AK000601 AK097880 AK302784 BC012565
RefSeq transcript (Entrez)NM_001014990 NM_014180
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MRPL22
Cluster EST : UnigeneHs.483924 [ NCBI ]
CGAP (NCI)Hs.483924
Alternative Splicing GalleryENSG00000082515
Gene ExpressionMRPL22 [ NCBI-GEO ]   MRPL22 [ EBI - ARRAY_EXPRESS ]   MRPL22 [ SEEK ]   MRPL22 [ MEM ]
Gene Expression Viewer (FireBrowse)MRPL22 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)29093
GTEX Portal (Tissue expression)MRPL22
Human Protein AtlasENSG00000082515-MRPL22 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NWU5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NWU5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NWU5
Splice isoforms : SwissVarQ9NWU5
PhosPhoSitePlusQ9NWU5
Domains : Interpro (EBI)Ribosomal_L22    Ribosomal_L22_bac/chlpt-type   
Domain families : Pfam (Sanger)Ribosomal_L22 (PF00237)   
Domain families : Pfam (NCBI)pfam00237   
Conserved Domain (NCBI)MRPL22
DMDM Disease mutations29093
Blocks (Seattle)MRPL22
PDB (SRS)3J7Y   
PDB (PDBSum)3J7Y   
PDB (IMB)3J7Y   
PDB (RSDB)3J7Y   
Structural Biology KnowledgeBase3J7Y   
SCOP (Structural Classification of Proteins)3J7Y   
CATH (Classification of proteins structures)3J7Y   
SuperfamilyQ9NWU5
Human Protein Atlas [tissue]ENSG00000082515-MRPL22 [tissue]
Peptide AtlasQ9NWU5
HPRD14748
IPIIPI00977524   IPI00556611   IPI00414410   IPI00977335   IPI00978032   
Protein Interaction databases
DIP (DOE-UCLA)Q9NWU5
IntAct (EBI)Q9NWU5
FunCoupENSG00000082515
BioGRIDMRPL22
STRING (EMBL)MRPL22
ZODIACMRPL22
Ontologies - Pathways
QuickGOQ9NWU5
Ontology : AmiGORNA binding  structural constituent of ribosome  mitochondrion  mitochondrial inner membrane  mitochondrial large ribosomal subunit  mitochondrial translational elongation  mitochondrial translational termination  
Ontology : EGO-EBIRNA binding  structural constituent of ribosome  mitochondrion  mitochondrial inner membrane  mitochondrial large ribosomal subunit  mitochondrial translational elongation  mitochondrial translational termination  
Pathways : KEGGRibosome   
NDEx NetworkMRPL22
Atlas of Cancer Signalling NetworkMRPL22
Wikipedia pathwaysMRPL22
Orthology - Evolution
OrthoDB29093
GeneTree (enSembl)ENSG00000082515
Phylogenetic Trees/Animal Genes : TreeFamMRPL22
HOVERGENQ9NWU5
HOGENOMQ9NWU5
Homologs : HomoloGeneMRPL22
Homology/Alignments : Family Browser (UCSC)MRPL22
Gene fusions - Rearrangements
Tumor Fusion PortalMRPL22
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRPL22 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRPL22
dbVarMRPL22
ClinVarMRPL22
1000_GenomesMRPL22 
Exome Variant ServerMRPL22
ExAC (Exome Aggregation Consortium)ENSG00000082515
GNOMAD BrowserENSG00000082515
Genetic variants : HAPMAP29093
Genomic Variants (DGV)MRPL22 [DGVbeta]
DECIPHERMRPL22 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRPL22 
Mutations
ICGC Data PortalMRPL22 
TCGA Data PortalMRPL22 
Broad Tumor PortalMRPL22
OASIS PortalMRPL22 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRPL22  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMRPL22
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MRPL22
DgiDB (Drug Gene Interaction Database)MRPL22
DoCM (Curated mutations)MRPL22 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MRPL22 (select a term)
intoGenMRPL22
Cancer3DMRPL22(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611835   
Orphanet
DisGeNETMRPL22
MedgenMRPL22
Genetic Testing Registry MRPL22
NextProtQ9NWU5 [Medical]
TSGene29093
GENETestsMRPL22
Target ValidationMRPL22
Huge Navigator MRPL22 [HugePedia]
snp3D : Map Gene to Disease29093
BioCentury BCIQMRPL22
ClinGenMRPL22
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD29093
Chemical/Pharm GKB GenePA30952
Clinical trialMRPL22
Miscellaneous
canSAR (ICR)MRPL22 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMRPL22
EVEXMRPL22
GoPubMedMRPL22
iHOPMRPL22
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:12:32 CET 2017

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