Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MRPL4 (mitochondrial ribosomal protein L4)

Identity

Alias (NCBI)CGI-28
L4mt
HGNC (Hugo) MRPL4
HGNC Alias symbCGI-28
LocusID (NCBI) 51073
Atlas_Id 54467
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10252214 and ends at 10260054 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MRPL4 (19p13.2) / ECI1 (16p13.3)QPCTL (19q13.32) / MRPL4 (19p13.2)SLC16A3 (17q25.3) / MRPL4 (19p13.2)
STAU1 (20q13.13) / MRPL4 (19p13.2)STAU1 20q13.13 / MRPL4 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MRPL4   14276
Cards
Entrez_Gene (NCBI)MRPL4    mitochondrial ribosomal protein L4
AliasesCGI-28; L4mt
GeneCards (Weizmann)MRPL4
Ensembl hg19 (Hinxton)ENSG00000105364 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105364 [Gene_View]  ENSG00000105364 [Sequence]  chr19:10252214-10260054 [Contig_View]  MRPL4 [Vega]
ICGC DataPortalENSG00000105364
TCGA cBioPortalMRPL4
AceView (NCBI)MRPL4
Genatlas (Paris)MRPL4
SOURCE (Princeton)MRPL4
Genetics Home Reference (NIH)MRPL4
Genomic and cartography
GoldenPath hg38 (UCSC)MRPL4  -     chr19:10252214-10260054 +  19p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRPL4  -     19p13.2   [Description]    (hg19-Feb_2009)
GoldenPathMRPL4 - 19p13.2 [CytoView hg19]  MRPL4 - 19p13.2 [CytoView hg38]
ImmunoBaseENSG00000105364
Genome Data Viewer NCBIMRPL4 [Mapview hg19]  
OMIM611823   
Gene and transcription
Genbank (Entrez)AB049635 AF132962 AI092267 AL561917 AY007152
RefSeq transcript (Entrez)NM_015956 NM_146387 NM_146388
Consensus coding sequences : CCDS (NCBI)MRPL4
Gene ExpressionMRPL4 [ NCBI-GEO ]   MRPL4 [ EBI - ARRAY_EXPRESS ]   MRPL4 [ SEEK ]   MRPL4 [ MEM ]
Gene Expression Viewer (FireBrowse)MRPL4 [ Firebrowse - Broad ]
GenevisibleExpression of MRPL4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51073
GTEX Portal (Tissue expression)MRPL4
Human Protein AtlasENSG00000105364-MRPL4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYD3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYD3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYD3
PhosPhoSitePlusQ9BYD3
Domains : Interpro (EBI)Ribosomal_L4/L1e    Ribosomal_L4_dom_sf    Ribosomal_uL4/L1e   
Domain families : Pfam (Sanger)Ribosomal_L4 (PF00573)   
Domain families : Pfam (NCBI)pfam00573   
Conserved Domain (NCBI)MRPL4
PDB (RSDB)3J7Y    3J9M    5OOL    5OOM    6I9R    6NU2    6NU3    6VLZ    6VMI    6ZS9    6ZSA    6ZSB    6ZSC    6ZSD    6ZSE    6ZSG   
PDB Europe3J7Y    3J9M    5OOL    5OOM    6I9R    6NU2    6NU3    6VLZ    6VMI    6ZS9    6ZSA    6ZSB    6ZSC    6ZSD    6ZSE    6ZSG   
PDB (PDBSum)3J7Y    3J9M    5OOL    5OOM    6I9R    6NU2    6NU3    6VLZ    6VMI    6ZS9    6ZSA    6ZSB    6ZSC    6ZSD    6ZSE    6ZSG   
PDB (IMB)3J7Y    3J9M    5OOL    5OOM    6I9R    6NU2    6NU3    6VLZ    6VMI    6ZS9    6ZSA    6ZSB    6ZSC    6ZSD    6ZSE    6ZSG   
Structural Biology KnowledgeBase3J7Y    3J9M    5OOL    5OOM    6I9R    6NU2    6NU3    6VLZ    6VMI    6ZS9    6ZSA    6ZSB    6ZSC    6ZSD    6ZSE    6ZSG   
SCOP (Structural Classification of Proteins)3J7Y    3J9M    5OOL    5OOM    6I9R    6NU2    6NU3    6VLZ    6VMI    6ZS9    6ZSA    6ZSB    6ZSC    6ZSD    6ZSE    6ZSG   
CATH (Classification of proteins structures)3J7Y    3J9M    5OOL    5OOM    6I9R    6NU2    6NU3    6VLZ    6VMI    6ZS9    6ZSA    6ZSB    6ZSC    6ZSD    6ZSE    6ZSG   
SuperfamilyQ9BYD3
AlphaFold pdb e-kbQ9BYD3   
Human Protein Atlas [tissue]ENSG00000105364-MRPL4 [tissue]
HPRD14759
Protein Interaction databases
DIP (DOE-UCLA)Q9BYD3
IntAct (EBI)Q9BYD3
BioGRIDMRPL4
STRING (EMBL)MRPL4
ZODIACMRPL4
Ontologies - Pathways
QuickGOQ9BYD3
Ontology : AmiGORNA binding  structural constituent of ribosome  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial large ribosomal subunit  mitochondrial translational elongation  mitochondrial translational termination  
Ontology : EGO-EBIRNA binding  structural constituent of ribosome  protein binding  mitochondrion  mitochondrial inner membrane  mitochondrial large ribosomal subunit  mitochondrial translational elongation  mitochondrial translational termination  
Pathways : KEGGRibosome   
NDEx NetworkMRPL4
Atlas of Cancer Signalling NetworkMRPL4
Wikipedia pathwaysMRPL4
Orthology - Evolution
OrthoDB51073
GeneTree (enSembl)ENSG00000105364
Phylogenetic Trees/Animal Genes : TreeFamMRPL4
Homologs : HomoloGeneMRPL4
Homology/Alignments : Family Browser (UCSC)MRPL4
Gene fusions - Rearrangements
Fusion : MitelmanSLC16A3/MRPL4 [17q25.3/19p13.2]  
Fusion : MitelmanSTAU1/MRPL4 [20q13.13/19p13.2]  
Fusion : QuiverMRPL4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRPL4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRPL4
dbVarMRPL4
ClinVarMRPL4
MonarchMRPL4
1000_GenomesMRPL4 
Exome Variant ServerMRPL4
GNOMAD BrowserENSG00000105364
Varsome BrowserMRPL4
ACMGMRPL4 variants
VarityQ9BYD3
Genomic Variants (DGV)MRPL4 [DGVbeta]
DECIPHERMRPL4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRPL4 
Mutations
ICGC Data PortalMRPL4 
TCGA Data PortalMRPL4 
Broad Tumor PortalMRPL4
OASIS PortalMRPL4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRPL4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMRPL4
Mutations and Diseases : HGMDMRPL4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMRPL4
DgiDB (Drug Gene Interaction Database)MRPL4
DoCM (Curated mutations)MRPL4
CIViC (Clinical Interpretations of Variants in Cancer)MRPL4
Cancer3DMRPL4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611823   
Orphanet
DisGeNETMRPL4
MedgenMRPL4
Genetic Testing Registry MRPL4
NextProtQ9BYD3 [Medical]
GENETestsMRPL4
Target ValidationMRPL4
Huge Navigator MRPL4 [HugePedia]
ClinGenMRPL4
Clinical trials, drugs, therapy
MyCancerGenomeMRPL4
Protein Interactions : CTDMRPL4
Pharm GKB GenePA30971
PharosQ9BYD3
Clinical trialMRPL4
Miscellaneous
canSAR (ICR)MRPL4
HarmonizomeMRPL4
DataMed IndexMRPL4
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMRPL4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:21:18 CEST 2021

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