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MRPL49 (mitochondrial ribosomal protein L49)

Identity

Alias_namesC11orf4
chromosome 11 open reading frame 4
Alias_symbol (synonym)NOF
NOF1
L49mt
Other aliasMRP-L49
HGNC (Hugo) MRPL49
LocusID (NCBI) 740
Atlas_Id 70464
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64889716 and ends at 64894841 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ANKRD37 (4q35.1) / MRPL49 (11q13.1)MRPL49 (11q13.1) / SLC25A45 (11q13.1)SYVN1 (11q13.1) / MRPL49 (11q13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MRPL49   1176
Cards
Entrez_Gene (NCBI)MRPL49  740  mitochondrial ribosomal protein L49
AliasesC11orf4; L49mt; MRP-L49; NOF; 
NOF1
GeneCards (Weizmann)MRPL49
Ensembl hg19 (Hinxton)ENSG00000149792 [Gene_View]  chr11:64889716-64894841 [Contig_View]  MRPL49 [Vega]
Ensembl hg38 (Hinxton)ENSG00000149792 [Gene_View]  chr11:64889716-64894841 [Contig_View]  MRPL49 [Vega]
ICGC DataPortalENSG00000149792
TCGA cBioPortalMRPL49
AceView (NCBI)MRPL49
Genatlas (Paris)MRPL49
WikiGenes740
SOURCE (Princeton)MRPL49
Genetics Home Reference (NIH)MRPL49
Genomic and cartography
GoldenPath hg19 (UCSC)MRPL49  -     chr11:64889716-64894841 +  11q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MRPL49  -     11q13.1   [Description]    (hg38-Dec_2013)
EnsemblMRPL49 - 11q13.1 [CytoView hg19]  MRPL49 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIMRPL49 [Mapview hg19]  MRPL49 [Mapview hg38]
OMIM606866   
Gene and transcription
Genbank (Entrez)AB062395 AB209160 AK123252 AK129795 AK129986
RefSeq transcript (Entrez)NM_004927
RefSeq genomic (Entrez)NC_000011 NC_018922 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)MRPL49
Cluster EST : UnigeneHs.744882 [ NCBI ]
CGAP (NCI)Hs.744882
Alternative Splicing GalleryENSG00000149792
Gene ExpressionMRPL49 [ NCBI-GEO ]   MRPL49 [ EBI - ARRAY_EXPRESS ]   MRPL49 [ SEEK ]   MRPL49 [ MEM ]
Gene Expression Viewer (FireBrowse)MRPL49 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)740
GTEX Portal (Tissue expression)MRPL49
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13405   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13405  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13405
Splice isoforms : SwissVarQ13405
PhosPhoSitePlusQ13405
Domains : Interpro (EBI)Ribosomal_L49/IMG2   
Domain families : Pfam (Sanger)Img2 (PF05046)   
Domain families : Pfam (NCBI)pfam05046   
Conserved Domain (NCBI)MRPL49
DMDM Disease mutations740
Blocks (Seattle)MRPL49
PDB (SRS)3J7Y   
PDB (PDBSum)3J7Y   
PDB (IMB)3J7Y   
PDB (RSDB)3J7Y   
Structural Biology KnowledgeBase3J7Y   
SCOP (Structural Classification of Proteins)3J7Y   
CATH (Classification of proteins structures)3J7Y   
SuperfamilyQ13405
Human Protein AtlasENSG00000149792
Peptide AtlasQ13405
HPRD06037
IPIIPI00013195   IPI00555553   IPI00985453   IPI00985377   IPI00984653   IPI00981529   
Protein Interaction databases
DIP (DOE-UCLA)Q13405
IntAct (EBI)Q13405
FunCoupENSG00000149792
BioGRIDMRPL49
STRING (EMBL)MRPL49
ZODIACMRPL49
Ontologies - Pathways
QuickGOQ13405
Ontology : AmiGOstructural constituent of ribosome  protein binding  mitochondrial inner membrane  mitochondrial ribosome  mitochondrial large ribosomal subunit  organelle organization  mitochondrial translation  mitochondrial translational initiation  mitochondrial translational elongation  mitochondrial translational termination  
Ontology : EGO-EBIstructural constituent of ribosome  protein binding  mitochondrial inner membrane  mitochondrial ribosome  mitochondrial large ribosomal subunit  organelle organization  mitochondrial translation  mitochondrial translational initiation  mitochondrial translational elongation  mitochondrial translational termination  
NDEx NetworkMRPL49
Atlas of Cancer Signalling NetworkMRPL49
Wikipedia pathwaysMRPL49
Orthology - Evolution
OrthoDB740
GeneTree (enSembl)ENSG00000149792
Phylogenetic Trees/Animal Genes : TreeFamMRPL49
HOVERGENQ13405
HOGENOMQ13405
Homologs : HomoloGeneMRPL49
Homology/Alignments : Family Browser (UCSC)MRPL49
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRPL49 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRPL49
dbVarMRPL49
ClinVarMRPL49
1000_GenomesMRPL49 
Exome Variant ServerMRPL49
ExAC (Exome Aggregation Consortium)MRPL49 (select the gene name)
Genetic variants : HAPMAP740
Genomic Variants (DGV)MRPL49 [DGVbeta]
DECIPHER (Syndromes)11:64889716-64894841  ENSG00000149792
CONAN: Copy Number AnalysisMRPL49 
Mutations
ICGC Data PortalMRPL49 
TCGA Data PortalMRPL49 
Broad Tumor PortalMRPL49
OASIS PortalMRPL49 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRPL49  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMRPL49
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MRPL49
DgiDB (Drug Gene Interaction Database)MRPL49
DoCM (Curated mutations)MRPL49 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MRPL49 (select a term)
intoGenMRPL49
Cancer3DMRPL49(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606866   
Orphanet
MedgenMRPL49
Genetic Testing Registry MRPL49
NextProtQ13405 [Medical]
TSGene740
GENETestsMRPL49
Huge Navigator MRPL49 [HugePedia]
snp3D : Map Gene to Disease740
BioCentury BCIQMRPL49
ClinGenMRPL49
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD740
Chemical/Pharm GKB GenePA30981
Clinical trialMRPL49
Miscellaneous
canSAR (ICR)MRPL49 (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMRPL49
EVEXMRPL49
GoPubMedMRPL49
iHOPMRPL49
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:33:45 CET 2017

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