Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MRPS18B (mitochondrial ribosomal protein S18B)

Identity

Alias_symbol (synonym)MRPS18-2
PTD017
C6orf14
HSPC183
Other aliasHumanS18a
MRP-S18-2
S18amt
HGNC (Hugo) MRPS18B
LocusID (NCBI) 28973
Atlas_Id 54472
Location 6p21.33  [Link to chromosome band 6p21]
Location_base_pair Starts at 30617709 and ends at 30626397 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DDR1 (6p21.33) / MRPS18B (6p21.33)GAPDH (12p13.31) / MRPS18B (6p21.33)GMDS (6p25.3) / MRPS18B (6p21.33)
MRPS18B (6p21.33) / NPIPB7 (16q23.1)TMEM176B (7q36.1) / MRPS18B (6p21.33)GMDS 6p25.3 / MRPS18B 6p21.33

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(6;6)(p21;p21) DDR1/MRPS18B
t(6;6)(p21;p25) GMDS/MRPS18B
t(6;12)(p21;p13) GAPDH/MRPS18B


External links

Nomenclature
HGNC (Hugo)MRPS18B   14516
Cards
Entrez_Gene (NCBI)MRPS18B  28973  mitochondrial ribosomal protein S18B
AliasesC6orf14; HSPC183; HumanS18a; MRP-S18-2; 
MRPS18-2; PTD017; S18amt
GeneCards (Weizmann)MRPS18B
Ensembl hg19 (Hinxton)ENSG00000204568 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000204568 [Gene_View]  ENSG00000204568 [Sequence]  chr6:30617709-30626397 [Contig_View]  MRPS18B [Vega]
ICGC DataPortalENSG00000204568
TCGA cBioPortalMRPS18B
AceView (NCBI)MRPS18B
Genatlas (Paris)MRPS18B
WikiGenes28973
SOURCE (Princeton)MRPS18B
Genetics Home Reference (NIH)MRPS18B
Genomic and cartography
GoldenPath hg38 (UCSC)MRPS18B  -     chr6:30617709-30626397 +  6p21.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRPS18B  -     6p21.33   [Description]    (hg19-Feb_2009)
EnsemblMRPS18B - 6p21.33 [CytoView hg19]  MRPS18B - 6p21.33 [CytoView hg38]
Mapping of homologs : NCBIMRPS18B [Mapview hg19]  MRPS18B [Mapview hg38]
OMIM611982   
Gene and transcription
Genbank (Entrez)AF100761 AF151017 AK294086 AK311890 AL050361
RefSeq transcript (Entrez)NM_014046
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_113891 NT_167245 NT_167246 NT_167247 NT_167248 NT_167249
Consensus coding sequences : CCDS (NCBI)MRPS18B
Cluster EST : UnigeneHs.655329 [ NCBI ]
CGAP (NCI)Hs.655329
Alternative Splicing GalleryENSG00000204568
Gene ExpressionMRPS18B [ NCBI-GEO ]   MRPS18B [ EBI - ARRAY_EXPRESS ]   MRPS18B [ SEEK ]   MRPS18B [ MEM ]
Gene Expression Viewer (FireBrowse)MRPS18B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)28973
GTEX Portal (Tissue expression)MRPS18B
Human Protein AtlasENSG00000204568-MRPS18B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y676   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y676  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y676
Splice isoforms : SwissVarQ9Y676
PhosPhoSitePlusQ9Y676
Domains : Interpro (EBI)Ribosomal_S18   
Domain families : Pfam (Sanger)Ribosomal_S18 (PF01084)   
Domain families : Pfam (NCBI)pfam01084   
Domain structure : Prodom (Prabi Lyon)Ribosomal_S18 (PD002239)   
Conserved Domain (NCBI)MRPS18B
DMDM Disease mutations28973
Blocks (Seattle)MRPS18B
PDB (SRS)3J9M   
PDB (PDBSum)3J9M   
PDB (IMB)3J9M   
PDB (RSDB)3J9M   
Structural Biology KnowledgeBase3J9M   
SCOP (Structural Classification of Proteins)3J9M   
CATH (Classification of proteins structures)3J9M   
SuperfamilyQ9Y676
Human Protein Atlas [tissue]ENSG00000204568-MRPS18B [tissue]
Peptide AtlasQ9Y676
HPRD14781
IPIIPI00022316   IPI01013185   IPI00445391   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y676
IntAct (EBI)Q9Y676
FunCoupENSG00000204568
BioGRIDMRPS18B
STRING (EMBL)MRPS18B
ZODIACMRPS18B
Ontologies - Pathways
QuickGOQ9Y676
Ontology : AmiGOstructural constituent of ribosome  structural constituent of ribosome  protein binding  nucleoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  translation  cell junction  mitochondrial translation  mitochondrial translational elongation  mitochondrial translational termination  
Ontology : EGO-EBIstructural constituent of ribosome  structural constituent of ribosome  protein binding  nucleoplasm  mitochondrion  mitochondrial inner membrane  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  translation  cell junction  mitochondrial translation  mitochondrial translational elongation  mitochondrial translational termination  
NDEx NetworkMRPS18B
Atlas of Cancer Signalling NetworkMRPS18B
Wikipedia pathwaysMRPS18B
Orthology - Evolution
OrthoDB28973
GeneTree (enSembl)ENSG00000204568
Phylogenetic Trees/Animal Genes : TreeFamMRPS18B
HOVERGENQ9Y676
HOGENOMQ9Y676
Homologs : HomoloGeneMRPS18B
Homology/Alignments : Family Browser (UCSC)MRPS18B
Gene fusions - Rearrangements
Fusion : MitelmanDDR1/MRPS18B [6p21.33/6p21.33]  [t(6;6)(p21;p21)]  
Fusion : MitelmanGAPDH/MRPS18B [12p13.31/6p21.33]  [t(6;12)(p21;p13)]  
Fusion : MitelmanGMDS/MRPS18B [6p25.3/6p21.33]  [t(6;6)(p21;p25)]  
Fusion PortalGMDS 6p25.3 MRPS18B 6p21.33 BLCA
Fusion : QuiverMRPS18B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRPS18B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRPS18B
dbVarMRPS18B
ClinVarMRPS18B
1000_GenomesMRPS18B 
Exome Variant ServerMRPS18B
ExAC (Exome Aggregation Consortium)ENSG00000204568
GNOMAD BrowserENSG00000204568
Genetic variants : HAPMAP28973
Genomic Variants (DGV)MRPS18B [DGVbeta]
DECIPHERMRPS18B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRPS18B 
Mutations
ICGC Data PortalMRPS18B 
TCGA Data PortalMRPS18B 
Broad Tumor PortalMRPS18B
OASIS PortalMRPS18B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRPS18B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMRPS18B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MRPS18B
DgiDB (Drug Gene Interaction Database)MRPS18B
DoCM (Curated mutations)MRPS18B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MRPS18B (select a term)
intoGenMRPS18B
Cancer3DMRPS18B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611982   
Orphanet
DisGeNETMRPS18B
MedgenMRPS18B
Genetic Testing Registry MRPS18B
NextProtQ9Y676 [Medical]
TSGene28973
GENETestsMRPS18B
Target ValidationMRPS18B
Huge Navigator MRPS18B [HugePedia]
snp3D : Map Gene to Disease28973
BioCentury BCIQMRPS18B
ClinGenMRPS18B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD28973
Chemical/Pharm GKB GenePA31004
Clinical trialMRPS18B
Miscellaneous
canSAR (ICR)MRPS18B (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMRPS18B
EVEXMRPS18B
GoPubMedMRPS18B
iHOPMRPS18B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:38:36 CEST 2018

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