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MRPS27 (mitochondrial ribosomal protein S27)

Identity

Alias (NCBI)MRP-S27
S27mt
HGNC (Hugo) MRPS27
HGNC Alias symbKIAA0264
LocusID (NCBI) 23107
Atlas_Id 57220
Location 5q13.2  [Link to chromosome band 5q13]
Location_base_pair Starts at 72219403 and ends at 72320240 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAST4 (5q12.3) / MRPS27 (5q13.2)MRPS27 (5q13.2) / MRPS27 (5q13.2)RNF217 (6q22.31) / MRPS27 (5q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;5)(q12;q13) MAST4/MRPS27


External links

Nomenclature
HGNC (Hugo)MRPS27   14512
Cards
Entrez_Gene (NCBI)MRPS27  23107  mitochondrial ribosomal protein S27
AliasesMRP-S27; S27mt
GeneCards (Weizmann)MRPS27
Ensembl hg19 (Hinxton)ENSG00000113048 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113048 [Gene_View]  ENSG00000113048 [Sequence]  chr5:72219403-72320240 [Contig_View]  MRPS27 [Vega]
ICGC DataPortalENSG00000113048
TCGA cBioPortalMRPS27
AceView (NCBI)MRPS27
Genatlas (Paris)MRPS27
WikiGenes23107
SOURCE (Princeton)MRPS27
Genetics Home Reference (NIH)MRPS27
Genomic and cartography
GoldenPath hg38 (UCSC)MRPS27  -     chr5:72219403-72320240 -  5q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRPS27  -     5q13.2   [Description]    (hg19-Feb_2009)
GoldenPathMRPS27 - 5q13.2 [CytoView hg19]  MRPS27 - 5q13.2 [CytoView hg38]
ImmunoBaseENSG00000113048
genome Data Viewer NCBIMRPS27 [Mapview hg19]  
OMIM611989   
Gene and transcription
Genbank (Entrez)AK025417 AK027001 AK095964 AK128683 AK296581
RefSeq transcript (Entrez)NM_001286748 NM_001286751 NM_015084
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MRPS27
Alternative Splicing GalleryENSG00000113048
Gene ExpressionMRPS27 [ NCBI-GEO ]   MRPS27 [ EBI - ARRAY_EXPRESS ]   MRPS27 [ SEEK ]   MRPS27 [ MEM ]
Gene Expression Viewer (FireBrowse)MRPS27 [ Firebrowse - Broad ]
GenevisibleExpression of MRPS27 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23107
GTEX Portal (Tissue expression)MRPS27
Human Protein AtlasENSG00000113048-MRPS27 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92552   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92552  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92552
Splice isoforms : SwissVarQ92552
PhosPhoSitePlusQ92552
Domaine pattern : Prosite (Expaxy)PPR (PS51375)   
Domains : Interpro (EBI)MRPS27    MRPS27/PTCD2    Pentatricopeptide_repeat    TPR-like_helical_dom_sf   
Domain families : Pfam (Sanger)MRP-S27 (PF10037)   
Domain families : Pfam (NCBI)pfam10037   
Conserved Domain (NCBI)MRPS27
DMDM Disease mutations23107
Blocks (Seattle)MRPS27
PDB (RSDB)3J9M    6NU2    6NU3   
PDB Europe3J9M    6NU2    6NU3   
PDB (PDBSum)3J9M    6NU2    6NU3   
PDB (IMB)3J9M    6NU2    6NU3   
Structural Biology KnowledgeBase3J9M    6NU2    6NU3   
SCOP (Structural Classification of Proteins)3J9M    6NU2    6NU3   
CATH (Classification of proteins structures)3J9M    6NU2    6NU3   
SuperfamilyQ92552
Human Protein Atlas [tissue]ENSG00000113048-MRPS27 [tissue]
Peptide AtlasQ92552
IPIIPI00942760   IPI00967112   IPI00022002   IPI00965465   IPI00982189   IPI00985234   
Protein Interaction databases
DIP (DOE-UCLA)Q92552
IntAct (EBI)Q92552
FunCoupENSG00000113048
BioGRIDMRPS27
STRING (EMBL)MRPS27
ZODIACMRPS27
Ontologies - Pathways
QuickGOQ92552
Ontology : AmiGOtRNA binding  protein binding  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial small ribosomal subunit  plasma membrane  cell proliferation  rRNA binding  mitochondrial translational elongation  mitochondrial translational termination  positive regulation of mitochondrial translation  mitochondrial ribosome binding  
Ontology : EGO-EBItRNA binding  protein binding  nucleoplasm  nucleolus  cytoplasm  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial small ribosomal subunit  plasma membrane  cell proliferation  rRNA binding  mitochondrial translational elongation  mitochondrial translational termination  positive regulation of mitochondrial translation  mitochondrial ribosome binding  
NDEx NetworkMRPS27
Atlas of Cancer Signalling NetworkMRPS27
Wikipedia pathwaysMRPS27
Orthology - Evolution
OrthoDB23107
GeneTree (enSembl)ENSG00000113048
Phylogenetic Trees/Animal Genes : TreeFamMRPS27
HOGENOMQ92552
Homologs : HomoloGeneMRPS27
Homology/Alignments : Family Browser (UCSC)MRPS27
Gene fusions - Rearrangements
Fusion : QuiverMRPS27
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRPS27 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRPS27
dbVarMRPS27
ClinVarMRPS27
MonarchMRPS27
1000_GenomesMRPS27 
Exome Variant ServerMRPS27
GNOMAD BrowserENSG00000113048
Varsome BrowserMRPS27
Genetic variants : HAPMAP23107
Genomic Variants (DGV)MRPS27 [DGVbeta]
DECIPHERMRPS27 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRPS27 
Mutations
ICGC Data PortalMRPS27 
TCGA Data PortalMRPS27 
Broad Tumor PortalMRPS27
OASIS PortalMRPS27 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRPS27  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMRPS27
Mutations and Diseases : HGMDMRPS27
BioMutasearch MRPS27
DgiDB (Drug Gene Interaction Database)MRPS27
DoCM (Curated mutations)MRPS27 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MRPS27 (select a term)
intoGenMRPS27
Cancer3DMRPS27(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611989   
Orphanet
DisGeNETMRPS27
MedgenMRPS27
Genetic Testing Registry MRPS27
NextProtQ92552 [Medical]
TSGene23107
GENETestsMRPS27
Target ValidationMRPS27
Huge Navigator MRPS27 [HugePedia]
snp3D : Map Gene to Disease23107
BioCentury BCIQMRPS27
ClinGenMRPS27
Clinical trials, drugs, therapy
Protein Interactions : CTD23107
Pharm GKB GenePA31015
Clinical trialMRPS27
Miscellaneous
canSAR (ICR)MRPS27 (select the gene name)
HarmonizomeMRPS27
DataMed IndexMRPS27
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMRPS27
EVEXMRPS27
GoPubMedMRPS27
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 14 14:22:53 CEST 2020

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