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MRPS35 (mitochondrial ribosomal protein S35)

Identity

Alias_symbol (synonym)MRPS28
MDS023
Other aliasHDCMD11P
MRP-S28
HGNC (Hugo) MRPS35
LocusID (NCBI) 60488
Atlas_Id 54474
Location 12p11.22  [Link to chromosome band 12p11]
Location_base_pair Starts at 27710773 and ends at 27756304 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
HSPA14 (10p13) / MRPS35 (12p11.22)KLHL42 (12p11.22) / MRPS35 (12p11.22)MRPS35 (12p11.22) / CSTA (3q21.1)
MRPS35 (12p11.22) / PPFIBP1 (12p11.23)MRPS35 (12p11.22) / STK38L (12p11.23)NAA50 (3q13.2) / MRPS35 (12p11.22)
HSPA14 10p13 / MRPS35 12p11.22KLHDC5 MRPS35 12p11.22MRPS35 12p11.22 / PPFIBP1 12p11.23

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Small Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)MRPS35   16635
Cards
Entrez_Gene (NCBI)MRPS35  60488  mitochondrial ribosomal protein S35
AliasesHDCMD11P; MDS023; MRP-S28; MRPS28
GeneCards (Weizmann)MRPS35
Ensembl hg19 (Hinxton)ENSG00000061794 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000061794 [Gene_View]  chr12:27710773-27756304 [Contig_View]  MRPS35 [Vega]
ICGC DataPortalENSG00000061794
TCGA cBioPortalMRPS35
AceView (NCBI)MRPS35
Genatlas (Paris)MRPS35
WikiGenes60488
SOURCE (Princeton)MRPS35
Genetics Home Reference (NIH)MRPS35
Genomic and cartography
GoldenPath hg38 (UCSC)MRPS35  -     chr12:27710773-27756304 +  12p11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MRPS35  -     12p11.22   [Description]    (hg19-Feb_2009)
EnsemblMRPS35 - 12p11.22 [CytoView hg19]  MRPS35 - 12p11.22 [CytoView hg38]
Mapping of homologs : NCBIMRPS35 [Mapview hg19]  MRPS35 [Mapview hg38]
OMIM611995   
Gene and transcription
Genbank (Entrez)AF068296 AF182422 AI538796 AK075378 AK075515
RefSeq transcript (Entrez)NM_001190864 NM_021821
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MRPS35
Cluster EST : UnigeneHs.714076 [ NCBI ]
CGAP (NCI)Hs.714076
Alternative Splicing GalleryENSG00000061794
Gene ExpressionMRPS35 [ NCBI-GEO ]   MRPS35 [ EBI - ARRAY_EXPRESS ]   MRPS35 [ SEEK ]   MRPS35 [ MEM ]
Gene Expression Viewer (FireBrowse)MRPS35 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)60488
GTEX Portal (Tissue expression)MRPS35
Protein : pattern, domain, 3D structure
UniProt/SwissProtP82673   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP82673  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP82673
Splice isoforms : SwissVarP82673
PhosPhoSitePlusP82673
Domains : Interpro (EBI)Ribosomal_S24/S35_mit   
Domain families : Pfam (Sanger)MRP-S28 (PF10213)   
Domain families : Pfam (NCBI)pfam10213   
Conserved Domain (NCBI)MRPS35
DMDM Disease mutations60488
Blocks (Seattle)MRPS35
PDB (SRS)3J9M   
PDB (PDBSum)3J9M   
PDB (IMB)3J9M   
PDB (RSDB)3J9M   
Structural Biology KnowledgeBase3J9M   
SCOP (Structural Classification of Proteins)3J9M   
CATH (Classification of proteins structures)3J9M   
SuperfamilyP82673
Human Protein AtlasENSG00000061794
Peptide AtlasP82673
HPRD11373
IPIIPI00073779   IPI00168292   IPI01010463   IPI01009647   IPI00789834   
Protein Interaction databases
DIP (DOE-UCLA)P82673
IntAct (EBI)P82673
FunCoupENSG00000061794
BioGRIDMRPS35
STRING (EMBL)MRPS35
ZODIACMRPS35
Ontologies - Pathways
QuickGOP82673
Ontology : AmiGORNA binding  structural constituent of ribosome  mitochondrial inner membrane  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  DNA damage response, detection of DNA damage  mitochondrial translational elongation  mitochondrial translational termination  
Ontology : EGO-EBIRNA binding  structural constituent of ribosome  mitochondrial inner membrane  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  DNA damage response, detection of DNA damage  mitochondrial translational elongation  mitochondrial translational termination  
NDEx NetworkMRPS35
Atlas of Cancer Signalling NetworkMRPS35
Wikipedia pathwaysMRPS35
Orthology - Evolution
OrthoDB60488
GeneTree (enSembl)ENSG00000061794
Phylogenetic Trees/Animal Genes : TreeFamMRPS35
HOVERGENP82673
HOGENOMP82673
Homologs : HomoloGeneMRPS35
Homology/Alignments : Family Browser (UCSC)MRPS35
Gene fusions - Rearrangements
Fusion : MitelmanHSPA14/MRPS35 [10p13/12p11.22]  [t(10;12)(p13;p11)]  
Fusion : MitelmanKLHL42/MRPS35 [12p11.22/12p11.22]  [t(12;12)(p11;p11)]  
Fusion : MitelmanMRPS35/PPFIBP1 [12p11.22/12p11.23]  [t(12;12)(p11;p11)]  
Fusion : MitelmanNAA50/MRPS35 [3q13.2/12p11.22]  [t(3;12)(q13;p11)]  
Fusion: TCGAHSPA14 10p13 MRPS35 12p11.22 BRCA
Fusion: TCGAKLHDC5 MRPS35 12p11.22 BLCA
Fusion: TCGAMRPS35 12p11.22 PPFIBP1 12p11.23 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRPS35 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRPS35
dbVarMRPS35
ClinVarMRPS35
1000_GenomesMRPS35 
Exome Variant ServerMRPS35
ExAC (Exome Aggregation Consortium)MRPS35 (select the gene name)
Genetic variants : HAPMAP60488
Genomic Variants (DGV)MRPS35 [DGVbeta]
DECIPHERMRPS35 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMRPS35 
Mutations
ICGC Data PortalMRPS35 
TCGA Data PortalMRPS35 
Broad Tumor PortalMRPS35
OASIS PortalMRPS35 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRPS35  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMRPS35
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MRPS35
DgiDB (Drug Gene Interaction Database)MRPS35
DoCM (Curated mutations)MRPS35 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MRPS35 (select a term)
intoGenMRPS35
Cancer3DMRPS35(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611995   
Orphanet
MedgenMRPS35
Genetic Testing Registry MRPS35
NextProtP82673 [Medical]
TSGene60488
GENETestsMRPS35
Target ValidationMRPS35
Huge Navigator MRPS35 [HugePedia]
snp3D : Map Gene to Disease60488
BioCentury BCIQMRPS35
ClinGenMRPS35
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD60488
Chemical/Pharm GKB GenePA31022
Clinical trialMRPS35
Miscellaneous
canSAR (ICR)MRPS35 (select the gene name)
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMRPS35
EVEXMRPS35
GoPubMedMRPS35
iHOPMRPS35
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 14:00:42 CEST 2017

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