Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MRPS6 (mitochondrial ribosomal protein S6)

Identity

Alias_namesC21orf101
chromosome 21 open reading frame 101
Alias_symbol (synonym)MRP-S6
RPMS6
Other aliasS6mt
HGNC (Hugo) MRPS6
LocusID (NCBI) 64968
Atlas_Id 70492
Location 21q22.11  [Link to chromosome band 21q22]
Location_base_pair Starts at 35445823 and ends at 35515334 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DYRK1A (21q22.13) / MRPS6 (21q22.11)MRPS6 (21q22.11) / MRPS6 (21q22.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MRPS6   14051
Cards
Entrez_Gene (NCBI)MRPS6  64968  mitochondrial ribosomal protein S6
AliasesC21orf101; MRP-S6; RPMS6; S6mt
GeneCards (Weizmann)MRPS6
Ensembl hg19 (Hinxton)ENSG00000243927 [Gene_View]  chr21:35445823-35515334 [Contig_View]  MRPS6 [Vega]
Ensembl hg38 (Hinxton)ENSG00000243927 [Gene_View]  chr21:35445823-35515334 [Contig_View]  MRPS6 [Vega]
ICGC DataPortalENSG00000243927
TCGA cBioPortalMRPS6
AceView (NCBI)MRPS6
Genatlas (Paris)MRPS6
WikiGenes64968
SOURCE (Princeton)MRPS6
Genetics Home Reference (NIH)MRPS6
Genomic and cartography
GoldenPath hg19 (UCSC)MRPS6  -     chr21:35445823-35515334 +  21q22.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MRPS6  -     21q22.11   [Description]    (hg38-Dec_2013)
EnsemblMRPS6 - 21q22.11 [CytoView hg19]  MRPS6 - 21q22.11 [CytoView hg38]
Mapping of homologs : NCBIMRPS6 [Mapview hg19]  MRPS6 [Mapview hg38]
OMIM611973   
Gene and transcription
Genbank (Entrez)AB049942 AI799469 AK096374 AK312084 AY061855
RefSeq transcript (Entrez)NM_032476
RefSeq genomic (Entrez)NC_000021 NC_018932 NT_011512 NW_004929426
Consensus coding sequences : CCDS (NCBI)MRPS6
Cluster EST : UnigeneHs.302742 [ NCBI ]
CGAP (NCI)Hs.302742
Alternative Splicing GalleryENSG00000243927
Gene ExpressionMRPS6 [ NCBI-GEO ]   MRPS6 [ EBI - ARRAY_EXPRESS ]   MRPS6 [ SEEK ]   MRPS6 [ MEM ]
Gene Expression Viewer (FireBrowse)MRPS6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64968
GTEX Portal (Tissue expression)MRPS6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP82932   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP82932  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP82932
Splice isoforms : SwissVarP82932
PhosPhoSitePlusP82932
Domains : Interpro (EBI)Ribosomal_S6    Transl_elong_EF1B/ribosomal_S6   
Domain families : Pfam (Sanger)Ribosomal_S6 (PF01250)   
Domain families : Pfam (NCBI)pfam01250   
Conserved Domain (NCBI)MRPS6
DMDM Disease mutations64968
Blocks (Seattle)MRPS6
SuperfamilyP82932
Human Protein AtlasENSG00000243927
Peptide AtlasP82932
HPRD11374
IPIIPI00305668   
Protein Interaction databases
DIP (DOE-UCLA)P82932
IntAct (EBI)P82932
FunCoupENSG00000243927
BioGRIDMRPS6
STRING (EMBL)MRPS6
ZODIACMRPS6
Ontologies - Pathways
QuickGOP82932
Ontology : AmiGOstructural constituent of ribosome  structural constituent of ribosome  structural constituent of ribosome  protein binding  mitochondrial inner membrane  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  translation  organelle organization  small ribosomal subunit  mitochondrial translation  mitochondrial translation  mitochondrial translational initiation  mitochondrial translational elongation  mitochondrial translational termination  small ribosomal subunit rRNA binding  
Ontology : EGO-EBIstructural constituent of ribosome  structural constituent of ribosome  structural constituent of ribosome  protein binding  mitochondrial inner membrane  mitochondrial small ribosomal subunit  mitochondrial small ribosomal subunit  translation  organelle organization  small ribosomal subunit  mitochondrial translation  mitochondrial translation  mitochondrial translational initiation  mitochondrial translational elongation  mitochondrial translational termination  small ribosomal subunit rRNA binding  
Pathways : KEGGRibosome   
NDEx NetworkMRPS6
Atlas of Cancer Signalling NetworkMRPS6
Wikipedia pathwaysMRPS6
Orthology - Evolution
OrthoDB64968
GeneTree (enSembl)ENSG00000243927
Phylogenetic Trees/Animal Genes : TreeFamMRPS6
HOVERGENP82932
HOGENOMP82932
Homologs : HomoloGeneMRPS6
Homology/Alignments : Family Browser (UCSC)MRPS6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMRPS6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MRPS6
dbVarMRPS6
ClinVarMRPS6
1000_GenomesMRPS6 
Exome Variant ServerMRPS6
ExAC (Exome Aggregation Consortium)MRPS6 (select the gene name)
Genetic variants : HAPMAP64968
Genomic Variants (DGV)MRPS6 [DGVbeta]
DECIPHER (Syndromes)21:35445823-35515334  ENSG00000243927
CONAN: Copy Number AnalysisMRPS6 
Mutations
ICGC Data PortalMRPS6 
TCGA Data PortalMRPS6 
Broad Tumor PortalMRPS6
OASIS PortalMRPS6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMRPS6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMRPS6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MRPS6
DgiDB (Drug Gene Interaction Database)MRPS6
DoCM (Curated mutations)MRPS6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MRPS6 (select a term)
intoGenMRPS6
Cancer3DMRPS6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611973   
Orphanet
MedgenMRPS6
Genetic Testing Registry MRPS6
NextProtP82932 [Medical]
TSGene64968
GENETestsMRPS6
Huge Navigator MRPS6 [HugePedia]
snp3D : Map Gene to Disease64968
BioCentury BCIQMRPS6
ClinGenMRPS6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64968
Chemical/Pharm GKB GenePA31025
Clinical trialMRPS6
Miscellaneous
canSAR (ICR)MRPS6 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMRPS6
EVEXMRPS6
GoPubMedMRPS6
iHOPMRPS6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:33:51 CET 2017

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