MRTFB (myocardin related transcription factor B)

2018-07-01  

Identity

HGNC
LOCATION
16p13.12
LOCUSID
ALIAS
MKL2,MRTF-B,NPD001

Other Information

Locus ID:

NCBI: 57496
MIM: 609463
HGNC: 29819
Ensembl: ENSG00000186260

Variants:

dbSNP: 57496
ClinVar: 57496
TCGA: ENSG00000186260
COSMIC: MRTFB

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186260ENST00000318282Q9ULH7
ENSG00000186260ENST00000571589Q9ULH7
ENSG00000186260ENST00000571770I3L2A0
ENSG00000186260ENST00000572567I3L2S3
ENSG00000186260ENST00000573051Q9ULH7
ENSG00000186260ENST00000573434I3L3Z7
ENSG00000186260ENST00000574045Q9ULH7
ENSG00000186260ENST00000574998I3L0U1

References

Pubmed IDYearTitleCitations
249689372014HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells.315
191986012009Myocardin-related transcription factors and SRF are required for cytoskeletal dynamics and experimental metastasis.162
180564152007Dual roles of myocardin-related transcription factors in epithelial mesenchymal transition via slug induction and actin remodeling.99
179472372007Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.72
145659522003Megakaryoblastic leukemia-1/2, a transcriptional co-activator of serum response factor, is required for skeletal myogenic differentiation.57
204427442010Linkage and candidate gene studies of autism spectrum disorders in European populations.24
221390792012The transcriptional coactivators megakaryoblastic leukemia 1/2 mediate the effects of loss of the tumor suppressor deleted in liver cancer 1.21
238531042013Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence.14
206077052010C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma.13
236723132013Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases.11

Citation

Dessen P

MRTFB (myocardin related transcription factor B)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57410/mrtfb