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MS4A1 (membrane spanning 4-domains A1)

Identity

Alias_namesCD20
membrane-spanning 4-domains
Alias_symbol (synonym)B1
Bp35
MS4A2
Other aliasCVID5
LEU-16
S7
HGNC (Hugo) MS4A1
LocusID (NCBI) 931
Atlas_Id 45648
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 60223282 and ends at 60238225 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and Neck: Thymus: Thymoma: an overview


External links

Nomenclature
HGNC (Hugo)MS4A1   7315
LRG (Locus Reference Genomic)LRG_140
Cards
Entrez_Gene (NCBI)MS4A1  931  membrane spanning 4-domains A1
AliasesB1; Bp35; CD20; CVID5; 
LEU-16; MS4A2; S7
GeneCards (Weizmann)MS4A1
Ensembl hg19 (Hinxton)ENSG00000156738 [Gene_View]  chr11:60223282-60238225 [Contig_View]  MS4A1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000156738 [Gene_View]  chr11:60223282-60238225 [Contig_View]  MS4A1 [Vega]
ICGC DataPortalENSG00000156738
TCGA cBioPortalMS4A1
AceView (NCBI)MS4A1
Genatlas (Paris)MS4A1
WikiGenes931
SOURCE (Princeton)MS4A1
Genetics Home Reference (NIH)MS4A1
Genomic and cartography
GoldenPath hg19 (UCSC)MS4A1  -     chr11:60223282-60238225 +  11q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MS4A1  -     11q12.2   [Description]    (hg38-Dec_2013)
EnsemblMS4A1 - 11q12.2 [CytoView hg19]  MS4A1 - 11q12.2 [CytoView hg38]
Mapping of homologs : NCBIMS4A1 [Mapview hg19]  MS4A1 [Mapview hg38]
OMIM112210   613495   
Gene and transcription
Genbank (Entrez)AK225630 AK292168 AK300025 AK310118 AW504475
RefSeq transcript (Entrez)NM_021950 NM_152866
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_023388 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)MS4A1
Cluster EST : UnigeneHs.712553 [ NCBI ]
CGAP (NCI)Hs.712553
Alternative Splicing GalleryENSG00000156738
Gene ExpressionMS4A1 [ NCBI-GEO ]   MS4A1 [ EBI - ARRAY_EXPRESS ]   MS4A1 [ SEEK ]   MS4A1 [ MEM ]
Gene Expression Viewer (FireBrowse)MS4A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)931
GTEX Portal (Tissue expression)MS4A1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP11836   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP11836  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP11836
Splice isoforms : SwissVarP11836
PhosPhoSitePlusP11836
Domains : Interpro (EBI)CD20-like    MS4A    MS4A1   
Domain families : Pfam (Sanger)CD20 (PF04103)   
Domain families : Pfam (NCBI)pfam04103   
Conserved Domain (NCBI)MS4A1
DMDM Disease mutations931
Blocks (Seattle)MS4A1
PDB (SRS)1S8B    2OSL    3BKY    3PP4   
PDB (PDBSum)1S8B    2OSL    3BKY    3PP4   
PDB (IMB)1S8B    2OSL    3BKY    3PP4   
PDB (RSDB)1S8B    2OSL    3BKY    3PP4   
Structural Biology KnowledgeBase1S8B    2OSL    3BKY    3PP4   
SCOP (Structural Classification of Proteins)1S8B    2OSL    3BKY    3PP4   
CATH (Classification of proteins structures)1S8B    2OSL    3BKY    3PP4   
SuperfamilyP11836
Human Protein AtlasENSG00000156738
Peptide AtlasP11836
HPRD00204
IPIIPI00007880   IPI00979011   IPI00980375   IPI00977605   IPI00910599   IPI00975633   
Protein Interaction databases
DIP (DOE-UCLA)P11836
IntAct (EBI)P11836
FunCoupENSG00000156738
BioGRIDMS4A1
STRING (EMBL)MS4A1
ZODIACMS4A1
Ontologies - Pathways
QuickGOP11836
Ontology : AmiGOepidermal growth factor receptor binding  protein binding  extracellular space  integral component of plasma membrane  humoral immune response  external side of plasma membrane  MHC class II protein complex binding  B cell proliferation  extracellular exosome  
Ontology : EGO-EBIepidermal growth factor receptor binding  protein binding  extracellular space  integral component of plasma membrane  humoral immune response  external side of plasma membrane  MHC class II protein complex binding  B cell proliferation  extracellular exosome  
Pathways : KEGGHematopoietic cell lineage   
NDEx NetworkMS4A1
Atlas of Cancer Signalling NetworkMS4A1
Wikipedia pathwaysMS4A1
Orthology - Evolution
OrthoDB931
GeneTree (enSembl)ENSG00000156738
Phylogenetic Trees/Animal Genes : TreeFamMS4A1
HOVERGENP11836
HOGENOMP11836
Homologs : HomoloGeneMS4A1
Homology/Alignments : Family Browser (UCSC)MS4A1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMS4A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MS4A1
dbVarMS4A1
ClinVarMS4A1
1000_GenomesMS4A1 
Exome Variant ServerMS4A1
ExAC (Exome Aggregation Consortium)MS4A1 (select the gene name)
Genetic variants : HAPMAP931
Genomic Variants (DGV)MS4A1 [DGVbeta]
DECIPHER (Syndromes)11:60223282-60238225  ENSG00000156738
CONAN: Copy Number AnalysisMS4A1 
Mutations
ICGC Data PortalMS4A1 
TCGA Data PortalMS4A1 
Broad Tumor PortalMS4A1
OASIS PortalMS4A1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMS4A1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMS4A1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch MS4A1
DgiDB (Drug Gene Interaction Database)MS4A1
DoCM (Curated mutations)MS4A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MS4A1 (select a term)
intoGenMS4A1
Cancer3DMS4A1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM112210    613495   
Orphanet3469   
MedgenMS4A1
Genetic Testing Registry MS4A1
NextProtP11836 [Medical]
TSGene931
GENETestsMS4A1
Huge Navigator MS4A1 [HugePedia]
snp3D : Map Gene to Disease931
BioCentury BCIQMS4A1
ClinGenMS4A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD931
Chemical/Pharm GKB GenePA31111
Clinical trialMS4A1
Miscellaneous
canSAR (ICR)MS4A1 (select the gene name)
Probes
Litterature
PubMed117 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMS4A1
EVEXMS4A1
GoPubMedMS4A1
iHOPMS4A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:17:26 CET 2017

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