MS4A1 (membrane spanning 4-domains A1)

2007-02-01  

Identity

HGNC
LOCATION
11q12.2
LOCUSID
ALIAS
B1,Bp35,CD20,CVID5,FMC7,LEU-16,MS4A2,S7

Other Information

Locus ID:

NCBI: 931
MIM: 112210
HGNC: 7315
Ensembl: ENSG00000156738

Variants:

dbSNP: 931
ClinVar: 931
TCGA: ENSG00000156738
COSMIC: MS4A1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156738ENST00000345732P11836
ENSG00000156738ENST00000345732A0A024R507
ENSG00000156738ENST00000389939P11836
ENSG00000156738ENST00000389939A0A024R507
ENSG00000156738ENST00000528313P11836
ENSG00000156738ENST00000532073E9PKH8
ENSG00000156738ENST00000533306E9PPL6
ENSG00000156738ENST00000534668P11836
ENSG00000156738ENST00000534668A0A024R507
ENSG00000156738ENST00000674194A0A024R507

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
Hematopoietic cell lineageKEGGhsa04640

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164748364tositumomabChemicalLabelAnnotationassociated
PA164781375ibritumomabChemicalLabelAnnotationassociated
PA165291493ofatumumabChemicalLabelAnnotationassociated
PA166122586afutuzumabChemicalLabelAnnotation, MultilinkAnnotationassociated24795454
PA451261rituximabChemicalLabelAnnotationassociated

References

Pubmed IDYearTitleCitations
196416072009Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors.127
200388002010CD20 deficiency in humans results in impaired T cell-independent antibody responses.100
206410642010B-cell activation influences T-cell polarization and outcome of anti-CD20 B-cell depletion in central nervous system autoimmunity.98
123935412003Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts.67
214449182011Epitope characterization and crystal structure of GA101 provide insights into the molecular basis for type I/II distinction of CD20 antibodies.63
268583602016Differential Insulitic Profiles Determine the Extent of β-Cell Destruction and the Age at Onset of Type 1 Diabetes.58
192465612009Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance.53
249289972014Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients.52
180068392007Lymphoma chemovirotherapy: CD20-targeted and convertase-armed measles virus can synergize with fludarabine.51
203506572010CD20 as a target for therapeutic type I and II monoclonal antibodies.46

Citation

Dessen P

MS4A1 (membrane spanning 4-domains A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45648/ms4a1