MS4A2 (membrane spanning 4-domains A2)

2018-07-01  

Identity

HGNC
LOCATION
11q12.1
LOCUSID
ALIAS
APY,ATOPY,FCER1B,FCERI,IGEL,IGER,IGHER,MS4A1

Other Information

Locus ID:

NCBI: 2206
MIM: 147138
HGNC: 7316
Ensembl: ENSG00000149534

Variants:

dbSNP: 2206
ClinVar: 2206
TCGA: ENSG00000149534
COSMIC: MS4A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149534ENST00000278888Q01362
ENSG00000149534ENST00000524868E9PLJ1
ENSG00000149534ENST00000617306A0A0B4J2E9

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
Fc epsilon RI signaling pathwayKEGGko04664
AsthmaKEGGko05310
Fc epsilon RI signaling pathwayKEGGhsa04664
AsthmaKEGGhsa05310
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
177034122007Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.100
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
189490592008FcgammaRIV is a mouse IgE receptor that resembles macrophage FcepsilonRI in humans and promotes IgE-induced lung inflammation.48
192476922009Analyses of associations with asthma in four asthma population samples from Canada and Australia.39
192649732009Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.36
192589232009Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.26
200855992009A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2.23
200855992009A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2.23
123935952002Marked increase in CC chemokine gene expression in both human and mouse mast cell transcriptomes following Fcepsilon receptor I cross-linking: an interspecies comparison.22
191316622009A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.21

Citation

Dessen P

MS4A2 (membrane spanning 4-domains A2)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57438/ms4a2