MS4A3 (membrane spanning 4-domains A3)

2011-06-01  

Identity

HGNC
LOCATION
11q12.1
LOCUSID
ALIAS
CD20L,HTM4
FUSION GENES

Other Information

Locus ID:

NCBI: 932
MIM: 606498
HGNC: 7317
Ensembl: ENSG00000149516

Variants:

dbSNP: 932
ClinVar: 932
TCGA: ENSG00000149516
COSMIC: MS4A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149516ENST00000278865Q96HJ5
ENSG00000149516ENST00000358152Q96HJ5
ENSG00000149516ENST00000395032Q96HJ5
ENSG00000149516ENST00000525686E9PRW8
ENSG00000149516ENST00000534744Q96HJ5

Expression (GTEx)

0
1
2
3
4
5
6
7
8

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
198180992011Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues.13
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
258866162015EVI1 promotes tumor growth via transcriptional repression of MS4A3.10
156710172005Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.8
158301032005[Regulatory role of HTm4 gene in hematopoietic cell cycle].1
275798962016A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.1
292747792018Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis.1

Citation

Dessen P

MS4A3 (membrane spanning 4-domains A3)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52250/ms4a3