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MS4A4A (membrane spanning 4-domains A4A)

Identity

Alias_namesMS4A4
membrane-spanning 4-domains, subfamily A, member 4
membrane-spanning 4-domains, subfamily A, member 4A
Alias_symbol (synonym)CD20L1
MS4A7
Other alias4SPAN1
CD20-L1
HDCME31P
HGNC (Hugo) MS4A4A
LocusID (NCBI) 51338
Atlas_Id 70505
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 60280541 and ends at 60308972 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CNIH2 (11q13.2) / MS4A4A (11q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q12;q13) CNIH2/MS4A4A

External links

Nomenclature
HGNC (Hugo)MS4A4A   13371
Cards
Entrez_Gene (NCBI)MS4A4A  51338  membrane spanning 4-domains A4A
Aliases4SPAN1; CD20-L1; CD20L1; HDCME31P; 
MS4A4; MS4A7
GeneCards (Weizmann)MS4A4A
Ensembl hg19 (Hinxton)ENSG00000110079 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000110079 [Gene_View]  chr11:60280541-60308972 [Contig_View]  MS4A4A [Vega]
ICGC DataPortalENSG00000110079
TCGA cBioPortalMS4A4A
AceView (NCBI)MS4A4A
Genatlas (Paris)MS4A4A
WikiGenes51338
SOURCE (Princeton)MS4A4A
Genetics Home Reference (NIH)MS4A4A
Genomic and cartography
GoldenPath hg38 (UCSC)MS4A4A  -     chr11:60280541-60308972 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MS4A4A  -     11q12.2   [Description]    (hg19-Feb_2009)
EnsemblMS4A4A - 11q12.2 [CytoView hg19]  MS4A4A - 11q12.2 [CytoView hg38]
Mapping of homologs : NCBIMS4A4A [Mapview hg19]  MS4A4A [Mapview hg38]
OMIM606547   
Gene and transcription
Genbank (Entrez)AB013102 AB022821 AF068288 AF237912 AF350500
RefSeq transcript (Entrez)NM_001243266 NM_024021 NM_148975
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MS4A4A
Cluster EST : UnigeneHs.325960 [ NCBI ]
CGAP (NCI)Hs.325960
Alternative Splicing GalleryENSG00000110079
Gene ExpressionMS4A4A [ NCBI-GEO ]   MS4A4A [ EBI - ARRAY_EXPRESS ]   MS4A4A [ SEEK ]   MS4A4A [ MEM ]
Gene Expression Viewer (FireBrowse)MS4A4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51338
GTEX Portal (Tissue expression)MS4A4A
Human Protein AtlasENSG00000110079-MS4A4A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96JQ5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96JQ5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96JQ5
Splice isoforms : SwissVarQ96JQ5
PhosPhoSitePlusQ96JQ5
Domains : Interpro (EBI)CD20-like    MS4A    MS4A4A   
Domain families : Pfam (Sanger)CD20 (PF04103)   
Domain families : Pfam (NCBI)pfam04103   
Conserved Domain (NCBI)MS4A4A
DMDM Disease mutations51338
Blocks (Seattle)MS4A4A
SuperfamilyQ96JQ5
Human Protein Atlas [tissue]ENSG00000110079-MS4A4A [tissue]
Peptide AtlasQ96JQ5
HPRD08408
IPIIPI00096647   IPI00292233   IPI00171207   IPI00974195   IPI00979494   
Protein Interaction databases
DIP (DOE-UCLA)Q96JQ5
IntAct (EBI)Q96JQ5
FunCoupENSG00000110079
BioGRIDMS4A4A
STRING (EMBL)MS4A4A
ZODIACMS4A4A
Ontologies - Pathways
QuickGOQ96JQ5
Ontology : AmiGOintegral component of membrane  
Ontology : EGO-EBIintegral component of membrane  
NDEx NetworkMS4A4A
Atlas of Cancer Signalling NetworkMS4A4A
Wikipedia pathwaysMS4A4A
Orthology - Evolution
OrthoDB51338
GeneTree (enSembl)ENSG00000110079
Phylogenetic Trees/Animal Genes : TreeFamMS4A4A
HOVERGENQ96JQ5
HOGENOMQ96JQ5
Homologs : HomoloGeneMS4A4A
Homology/Alignments : Family Browser (UCSC)MS4A4A
Gene fusions - Rearrangements
Fusion : QuiverMS4A4A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMS4A4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MS4A4A
dbVarMS4A4A
ClinVarMS4A4A
1000_GenomesMS4A4A 
Exome Variant ServerMS4A4A
ExAC (Exome Aggregation Consortium)ENSG00000110079
GNOMAD BrowserENSG00000110079
Genetic variants : HAPMAP51338
Genomic Variants (DGV)MS4A4A [DGVbeta]
DECIPHERMS4A4A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMS4A4A 
Mutations
ICGC Data PortalMS4A4A 
TCGA Data PortalMS4A4A 
Broad Tumor PortalMS4A4A
OASIS PortalMS4A4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMS4A4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMS4A4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MS4A4A
DgiDB (Drug Gene Interaction Database)MS4A4A
DoCM (Curated mutations)MS4A4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MS4A4A (select a term)
intoGenMS4A4A
Cancer3DMS4A4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606547   
Orphanet
DisGeNETMS4A4A
MedgenMS4A4A
Genetic Testing Registry MS4A4A
NextProtQ96JQ5 [Medical]
TSGene51338
GENETestsMS4A4A
Target ValidationMS4A4A
Huge Navigator MS4A4A [HugePedia]
snp3D : Map Gene to Disease51338
BioCentury BCIQMS4A4A
ClinGenMS4A4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51338
Chemical/Pharm GKB GenePA31113
Clinical trialMS4A4A
Miscellaneous
canSAR (ICR)MS4A4A (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMS4A4A
EVEXMS4A4A
GoPubMedMS4A4A
iHOPMS4A4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 23 18:43:48 CET 2018
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