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MS4A8 (membrane spanning 4-domains A8)

Identity

Alias_namesMS4A8B
membrane-spanning 4-domains, subfamily A, member 8B
membrane-spanning 4-domains, subfamily A, member 8
Alias_symbol (synonym)MS4A4
CD20L5
Other alias4SPAN4
HGNC (Hugo) MS4A8
LocusID (NCBI) 83661
Atlas_Id 70511
Location 11q12.2  [Link to chromosome band 11q12]
Location_base_pair Starts at 60699574 and ends at 60715811 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SHANK2 (11q13.3) / MS4A8 (11q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q12;q13) SHANK2/MS4A8

External links

Nomenclature
HGNC (Hugo)MS4A8   13380
Cards
Entrez_Gene (NCBI)MS4A8  83661  membrane spanning 4-domains A8
Aliases4SPAN4; CD20L5; MS4A4; MS4A8B
GeneCards (Weizmann)MS4A8
Ensembl hg19 (Hinxton)ENSG00000166959 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166959 [Gene_View]  ENSG00000166959 [Sequence]  chr11:60699574-60715811 [Contig_View]  MS4A8 [Vega]
ICGC DataPortalENSG00000166959
TCGA cBioPortalMS4A8
AceView (NCBI)MS4A8
Genatlas (Paris)MS4A8
WikiGenes83661
SOURCE (Princeton)MS4A8
Genetics Home Reference (NIH)MS4A8
Genomic and cartography
GoldenPath hg38 (UCSC)MS4A8  -     chr11:60699574-60715811 +  11q12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MS4A8  -     11q12.2   [Description]    (hg19-Feb_2009)
EnsemblMS4A8 - 11q12.2 [CytoView hg19]  MS4A8 - 11q12.2 [CytoView hg38]
Mapping of homologs : NCBIMS4A8 [Mapview hg19]  MS4A8 [Mapview hg38]
OMIM606549   
Gene and transcription
Genbank (Entrez)AF237905 AF350504 AK308413 AK310872 AK310884
RefSeq transcript (Entrez)NM_031457
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MS4A8
Cluster EST : UnigeneHs.150878 [ NCBI ]
CGAP (NCI)Hs.150878
Alternative Splicing GalleryENSG00000166959
Gene ExpressionMS4A8 [ NCBI-GEO ]   MS4A8 [ EBI - ARRAY_EXPRESS ]   MS4A8 [ SEEK ]   MS4A8 [ MEM ]
Gene Expression Viewer (FireBrowse)MS4A8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)83661
GTEX Portal (Tissue expression)MS4A8
Human Protein AtlasENSG00000166959-MS4A8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BY19   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BY19  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BY19
Splice isoforms : SwissVarQ9BY19
PhosPhoSitePlusQ9BY19
Domains : Interpro (EBI)CD20-like    MS4A    MS4A8   
Domain families : Pfam (Sanger)CD20 (PF04103)   
Domain families : Pfam (NCBI)pfam04103   
Conserved Domain (NCBI)MS4A8
DMDM Disease mutations83661
Blocks (Seattle)MS4A8
SuperfamilyQ9BY19
Human Protein Atlas [tissue]ENSG00000166959-MS4A8 [tissue]
Peptide AtlasQ9BY19
HPRD08409
IPIIPI00027802   IPI00885188   IPI00979073   IPI00978305   IPI00980285   
Protein Interaction databases
DIP (DOE-UCLA)Q9BY19
IntAct (EBI)Q9BY19
FunCoupENSG00000166959
BioGRIDMS4A8
STRING (EMBL)MS4A8
ZODIACMS4A8
Ontologies - Pathways
QuickGOQ9BY19
Ontology : AmiGOintegral component of membrane  
Ontology : EGO-EBIintegral component of membrane  
NDEx NetworkMS4A8
Atlas of Cancer Signalling NetworkMS4A8
Wikipedia pathwaysMS4A8
Orthology - Evolution
OrthoDB83661
GeneTree (enSembl)ENSG00000166959
Phylogenetic Trees/Animal Genes : TreeFamMS4A8
HOVERGENQ9BY19
HOGENOMQ9BY19
Homologs : HomoloGeneMS4A8
Homology/Alignments : Family Browser (UCSC)MS4A8
Gene fusions - Rearrangements
Fusion : QuiverMS4A8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMS4A8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MS4A8
dbVarMS4A8
ClinVarMS4A8
1000_GenomesMS4A8 
Exome Variant ServerMS4A8
ExAC (Exome Aggregation Consortium)ENSG00000166959
GNOMAD BrowserENSG00000166959
Varsome BrowserMS4A8
Genetic variants : HAPMAP83661
Genomic Variants (DGV)MS4A8 [DGVbeta]
DECIPHERMS4A8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMS4A8 
Mutations
ICGC Data PortalMS4A8 
TCGA Data PortalMS4A8 
Broad Tumor PortalMS4A8
OASIS PortalMS4A8 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMS4A8
BioMutasearch MS4A8
DgiDB (Drug Gene Interaction Database)MS4A8
DoCM (Curated mutations)MS4A8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MS4A8 (select a term)
intoGenMS4A8
Cancer3DMS4A8(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606549   
Orphanet
DisGeNETMS4A8
MedgenMS4A8
Genetic Testing Registry MS4A8
NextProtQ9BY19 [Medical]
TSGene83661
GENETestsMS4A8
Target ValidationMS4A8
Huge Navigator MS4A8 [HugePedia]
snp3D : Map Gene to Disease83661
BioCentury BCIQMS4A8
ClinGenMS4A8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD83661
Chemical/Pharm GKB GenePA31126
Clinical trialMS4A8
Miscellaneous
canSAR (ICR)MS4A8 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMS4A8
EVEXMS4A8
GoPubMedMS4A8
iHOPMS4A8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 14:18:46 CEST 2018
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