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MSH4 (mutS homolog 4)

Identity

Other names-
HGNC (Hugo) MSH4
LocusID (NCBI) 4438
Location 1p31.1
Location_base_pair Starts at 76262556 and ends at 76378923 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MSH4   7327
Cards
Entrez_Gene (NCBI)MSH4  4438  mutS homolog 4
GeneCards (Weizmann)MSH4
Ensembl hg19 (Hinxton)ENSG00000057468 [Gene_View]  chr1:76262556-76378923 [Contig_View]  MSH4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000057468 [Gene_View]  chr1:76262556-76378923 [Contig_View]  MSH4 [Vega]
ICGC DataPortalENSG00000057468
cBioPortalMSH4
AceView (NCBI)MSH4
Genatlas (Paris)MSH4
WikiGenes4438
SOURCE (Princeton)MSH4
Genomic and cartography
GoldenPath hg19 (UCSC)MSH4  -     chr1:76262556-76378923 +  1p31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MSH4  -     1p31.1   [Description]    (hg38-Dec_2013)
EnsemblMSH4 - 1p31.1 [CytoView hg19]  MSH4 - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBIMSH4 [Mapview hg19]  MSH4 [Mapview hg38]
OMIM602105   
Gene and transcription
Genbank (Entrez)AF104243 AJ844635 BC033030 DB077677 DQ891259
RefSeq transcript (Entrez)NM_002440
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_029861 NT_032977 NW_001838579 NW_004929290
Consensus coding sequences : CCDS (NCBI)MSH4
Cluster EST : UnigeneHs.216639 [ NCBI ]
CGAP (NCI)Hs.216639
Alternative Splicing : Fast-db (Paris)GSHG0033102
Alternative Splicing GalleryENSG00000057468
Gene ExpressionMSH4 [ NCBI-GEO ]     MSH4 [ SEEK ]   MSH4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15457 (Uniprot)
NextProtO15457  [Medical]
With graphics : InterProO15457
Splice isoforms : SwissVarO15457 (Swissvar)
Domaine pattern : Prosite (Expaxy)DNA_MISMATCH_REPAIR_2 (PS00486)   
Domains : Interpro (EBI)DNA_mismatch_repair_MutS_C    DNA_mismatch_repair_MutS_clamp    DNA_mismatch_repair_MutS_core    DNA_mmatch_repair_MutS_con_dom    P-loop_NTPase   
Related proteins : CluSTrO15457
Domain families : Pfam (Sanger)MutS_II (PF05188)    MutS_III (PF05192)    MutS_IV (PF05190)    MutS_V (PF00488)   
Domain families : Pfam (NCBI)pfam05188    pfam05192    pfam05190    pfam00488   
Domain families : Smart (EMBL)MUTSac (SM00534)  MUTSd (SM00533)  
DMDM Disease mutations4438
Blocks (Seattle)O15457
Human Protein AtlasENSG00000057468
Peptide AtlasO15457
HPRD03658
IPIIPI00289914   
Protein Interaction databases
DIP (DOE-UCLA)O15457
IntAct (EBI)O15457
FunCoupENSG00000057468
BioGRIDMSH4
IntegromeDBMSH4
STRING (EMBL)MSH4
Ontologies - Pathways
QuickGOO15457
Ontology : AmiGOmeiotic mismatch repair  synaptonemal complex  ovarian follicle development  DNA binding  damaged DNA binding  protein binding  ATP binding  nucleus  ATP catabolic process  reciprocal meiotic recombination  spermatogenesis  female gamete generation  DNA-dependent ATPase activity  mismatched DNA binding  mismatch repair complex  homologous chromosome segregation  chiasma assembly  
Ontology : EGO-EBImeiotic mismatch repair  synaptonemal complex  ovarian follicle development  DNA binding  damaged DNA binding  protein binding  ATP binding  nucleus  ATP catabolic process  reciprocal meiotic recombination  spermatogenesis  female gamete generation  DNA-dependent ATPase activity  mismatched DNA binding  mismatch repair complex  homologous chromosome segregation  chiasma assembly  
Protein Interaction DatabaseMSH4
DoCM (Curated mutations)MSH4
Wikipedia pathwaysMSH4
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMSH4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MSH4
dbVarMSH4
ClinVarMSH4
1000_GenomesMSH4 
Exome Variant ServerMSH4
SNP (GeneSNP Utah)MSH4
SNP : HGBaseMSH4
Genetic variants : HAPMAPMSH4
Genomic VariantsMSH4  MSH4 [DGVbeta]
Mutations
ICGC Data PortalENSG00000057468 
Somatic Mutations in Cancer : COSMICMSH4 
CONAN: Copy Number AnalysisMSH4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:76262556-76378923
Mutations and Diseases : HGMDMSH4
OMIM602105   
MedgenMSH4
NextProtO15457 [Medical]
GENETestsMSH4
Disease Genetic AssociationMSH4
Huge Navigator MSH4 [HugePedia]  MSH4 [HugeCancerGEM]
snp3D : Map Gene to Disease4438
DGIdb (Drug Gene Interaction db)MSH4
General knowledge
Homologs : HomoloGeneMSH4
Homology/Alignments : Family Browser (UCSC)MSH4
Phylogenetic Trees/Animal Genes : TreeFamMSH4
Chemical/Protein Interactions : CTD4438
Chemical/Pharm GKB GenePA31135
Clinical trialMSH4
Cancer Resource (Charite)ENSG00000057468
Other databases
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
CoreMineMSH4
GoPubMedMSH4
iHOPMSH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sun Dec 21 00:19:41 CET 2014

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