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MSH4 (mutS homolog 4)

Identity

Other names-
HGNC (Hugo) MSH4
LocusID (NCBI) 4438
Location 1p31.1
Location_base_pair Starts at 76262556 and ends at 76378923 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MSH4   7327
Cards
Entrez_Gene (NCBI)MSH4  4438  mutS homolog 4
GeneCards (Weizmann)MSH4
Ensembl (Hinxton)ENSG00000057468 [Gene_View]  chr1:76262556-76378923 [Contig_View]  MSH4 [Vega]
ICGC DataPortalENSG00000057468
cBioPortalMSH4
AceView (NCBI)MSH4
Genatlas (Paris)MSH4
WikiGenes4438
SOURCE (Princeton)NM_002440
Genomic and cartography
GoldenPath (UCSC)MSH4  -  1p31.1   chr1:76262556-76378923 +  1p31.1   [Description]    (hg19-Feb_2009)
EnsemblMSH4 - 1p31.1 [CytoView]
Mapping of homologs : NCBIMSH4 [Mapview]
OMIM602105   
Gene and transcription
Genbank (Entrez)AF104243 AJ844635 BC033030 DB077677 DQ891259
RefSeq transcript (Entrez)NM_002440
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_029861 NT_032977 NW_001838579 NW_004929290
Consensus coding sequences : CCDS (NCBI)MSH4
Cluster EST : UnigeneHs.216639 [ NCBI ]
CGAP (NCI)Hs.216639
Alternative Splicing : Fast-db (Paris)GSHG0033102
Alternative Splicing GalleryENSG00000057468
Gene ExpressionMSH4 [ NCBI-GEO ]     MSH4 [ SEEK ]   MSH4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15457 (Uniprot)
NextProtO15457  [Medical]
With graphics : InterProO15457
Splice isoforms : SwissVarO15457 (Swissvar)
Domaine pattern : Prosite (Expaxy)DNA_MISMATCH_REPAIR_2 (PS00486)   
Domains : Interpro (EBI)DNA_mismatch_repair_MutS_C [organisation]   DNA_mismatch_repair_MutS_clamp [organisation]   DNA_mismatch_repair_MutS_core [organisation]   DNA_mmatch_repair_MutS_con_dom [organisation]   P-loop_NTPase [organisation]  
Related proteins : CluSTrO15457
Domain families : Pfam (Sanger)MutS_II (PF05188)    MutS_III (PF05192)    MutS_IV (PF05190)    MutS_V (PF00488)   
Domain families : Pfam (NCBI)pfam05188    pfam05192    pfam05190    pfam00488   
Domain families : Smart (EMBL)MUTSac (SM00534)  MUTSd (SM00533)  
DMDM Disease mutations4438
Blocks (Seattle)O15457
Human Protein AtlasENSG00000057468 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO15457
HPRD03658
IPIIPI00289914   
Protein Interaction databases
DIP (DOE-UCLA)O15457
IntAct (EBI)O15457
FunCoupENSG00000057468
BioGRIDMSH4
InParanoidO15457
Interologous Interaction database O15457
IntegromeDBMSH4
STRING (EMBL)MSH4
Ontologies - Pathways
Ontology : AmiGOmeiotic mismatch repair  synaptonemal complex  ovarian follicle development  DNA binding  damaged DNA binding  protein binding  ATP binding  nucleus  ATP catabolic process  reciprocal meiotic recombination  spermatogenesis  female gamete generation  DNA-dependent ATPase activity  mismatched DNA binding  mismatch repair complex  homologous chromosome segregation  chiasma assembly  
Ontology : EGO-EBImeiotic mismatch repair  synaptonemal complex  ovarian follicle development  DNA binding  damaged DNA binding  protein binding  ATP binding  nucleus  ATP catabolic process  reciprocal meiotic recombination  spermatogenesis  female gamete generation  DNA-dependent ATPase activity  mismatched DNA binding  mismatch repair complex  homologous chromosome segregation  chiasma assembly  
Protein Interaction DatabaseMSH4
Wikipedia pathwaysMSH4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MSH4
snp3D : Map Gene to Disease4438
SNP (GeneSNP Utah)MSH4
SNP : HGBaseMSH4
Genetic variants : HAPMAPMSH4
Exome VariantMSH4
1000_GenomesMSH4 
ICGC programENSG00000057468 
Somatic Mutations in Cancer : COSMICMSH4 
CONAN: Copy Number AnalysisMSH4 
Mutations and Diseases : HGMDMSH4
Mutations and Diseases : intOGenMSH4
Genomic VariantsMSH4  MSH4 [DGVbeta]
dbVarMSH4
ClinVarMSH4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM602105   
MedgenMSH4
GENETestsMSH4
Disease Genetic AssociationMSH4
Huge Navigator MSH4 [HugePedia]  MSH4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMSH4
Homology/Alignments : Family Browser (UCSC)MSH4
Phylogenetic Trees/Animal Genes : TreeFamMSH4
Chemical/Protein Interactions : CTD4438
Chemical/Pharm GKB GenePA31135
Clinical trialMSH4
Cancer Resource (Charite)ENSG00000057468
Other databases
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
CoreMineMSH4
iHOPMSH4
OncoSearchMSH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:56:36 CEST 2014

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