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MSH4 (mutS homolog 4)

Identity

Other names-
HGNC (Hugo) MSH4
LocusID (NCBI) 4438
Atlas_Id 342
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at 76262556 and ends at 76378923 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MSH4 (1p31.1) / RABGGTB (1p31.1)MSH4 (1p31.1) / ZNF652 (17q21.32)MSH4 1p31.1 / RABGGTB 1p31.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MSH4   7327
Cards
Entrez_Gene (NCBI)MSH4  4438  mutS homolog 4
Aliases
GeneCards (Weizmann)MSH4
Ensembl hg19 (Hinxton)ENSG00000057468 [Gene_View]  chr1:76262556-76378923 [Contig_View]  MSH4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000057468 [Gene_View]  chr1:76262556-76378923 [Contig_View]  MSH4 [Vega]
ICGC DataPortalENSG00000057468
TCGA cBioPortalMSH4
AceView (NCBI)MSH4
Genatlas (Paris)MSH4
WikiGenes4438
SOURCE (Princeton)MSH4
Genomic and cartography
GoldenPath hg19 (UCSC)MSH4  -     chr1:76262556-76378923 +  1p31.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MSH4  -     1p31.1   [Description]    (hg38-Dec_2013)
EnsemblMSH4 - 1p31.1 [CytoView hg19]  MSH4 - 1p31.1 [CytoView hg38]
Mapping of homologs : NCBIMSH4 [Mapview hg19]  MSH4 [Mapview hg38]
OMIM602105   
Gene and transcription
Genbank (Entrez)AF104243 AJ844635 BC033030 DB077677 DQ891259
RefSeq transcript (Entrez)NM_002440
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_029861 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)MSH4
Cluster EST : UnigeneHs.216639 [ NCBI ]
CGAP (NCI)Hs.216639
Alternative Splicing GalleryENSG00000057468
Gene ExpressionMSH4 [ NCBI-GEO ]   MSH4 [ EBI - ARRAY_EXPRESS ]   MSH4 [ SEEK ]   MSH4 [ MEM ]
Gene Expression Viewer (FireBrowse)MSH4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4438
GTEX Portal (Tissue expression)MSH4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15457 (Uniprot)
NextProtO15457  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15457
Splice isoforms : SwissVarO15457 (Swissvar)
PhosPhoSitePlusO15457
Domaine pattern : Prosite (Expaxy)DNA_MISMATCH_REPAIR_2 (PS00486)   
Domains : Interpro (EBI)DNA_mismatch_repair_MutS_C    DNA_mismatch_repair_MutS_clamp    DNA_mismatch_repair_MutS_core    DNA_mmatch_repair_MutS_con_dom    P-loop_NTPase   
Domain families : Pfam (Sanger)MutS_II (PF05188)    MutS_III (PF05192)    MutS_IV (PF05190)    MutS_V (PF00488)   
Domain families : Pfam (NCBI)pfam05188    pfam05192    pfam05190    pfam00488   
Domain families : Smart (EMBL)MUTSac (SM00534)  MUTSd (SM00533)  
DMDM Disease mutations4438
Blocks (Seattle)MSH4
SuperfamilyO15457
Human Protein AtlasENSG00000057468
Peptide AtlasO15457
HPRD03658
IPIIPI00289914   
Protein Interaction databases
DIP (DOE-UCLA)O15457
IntAct (EBI)O15457
FunCoupENSG00000057468
BioGRIDMSH4
STRING (EMBL)MSH4
ZODIACMSH4
Ontologies - Pathways
QuickGOO15457
Ontology : AmiGOmeiotic mismatch repair  synaptonemal complex  ovarian follicle development  DNA binding  damaged DNA binding  protein binding  ATP binding  nucleus  mismatch repair  synapsis  reciprocal meiotic recombination  spermatogenesis  female gamete generation  mismatched DNA binding  mismatch repair complex  homologous chromosome segregation  
Ontology : EGO-EBImeiotic mismatch repair  synaptonemal complex  ovarian follicle development  DNA binding  damaged DNA binding  protein binding  ATP binding  nucleus  mismatch repair  synapsis  reciprocal meiotic recombination  spermatogenesis  female gamete generation  mismatched DNA binding  mismatch repair complex  homologous chromosome segregation  
NDEx NetworkMSH4
Atlas of Cancer Signalling NetworkMSH4
Wikipedia pathwaysMSH4
Orthology - Evolution
OrthoDB4438
GeneTree (enSembl)ENSG00000057468
Phylogenetic Trees/Animal Genes : TreeFamMSH4
Homologs : HomoloGeneMSH4
Homology/Alignments : Family Browser (UCSC)MSH4
Gene fusions - Rearrangements
Fusion: TCGAMSH4 1p31.1 RABGGTB 1p31.1 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerMSH4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MSH4
dbVarMSH4
ClinVarMSH4
1000_GenomesMSH4 
Exome Variant ServerMSH4
ExAC (Exome Aggregation Consortium)MSH4 (select the gene name)
Genetic variants : HAPMAP4438
Genomic Variants (DGV)MSH4 [DGVbeta]
Mutations
ICGC Data PortalMSH4 
TCGA Data PortalMSH4 
Broad Tumor PortalMSH4
OASIS PortalMSH4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMSH4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MSH4
DgiDB (Drug Gene Interaction Database)MSH4
DoCM (Curated mutations)MSH4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MSH4 (select a term)
intoGenMSH4
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:76262556-76378923  ENSG00000057468
CONAN: Copy Number AnalysisMSH4 
Mutations and Diseases : HGMDMSH4
OMIM602105   
MedgenMSH4
Genetic Testing Registry MSH4
NextProtO15457 [Medical]
TSGene4438
GENETestsMSH4
Huge Navigator MSH4 [HugePedia]
snp3D : Map Gene to Disease4438
BioCentury BCIQMSH4
ClinGenMSH4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4438
Chemical/Pharm GKB GenePA31135
Clinical trialMSH4
Miscellaneous
canSAR (ICR)MSH4 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMSH4
EVEXMSH4
GoPubMedMSH4
iHOPMSH4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 19:03:13 CEST 2016

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