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MSLN (mesothelin)

Identity

Alias_symbol (synonym)CAK1
MPF
Other aliasSMRP
HGNC (Hugo) MSLN
LocusID (NCBI) 10232
Atlas_Id 41433
Location 16p13.3  [Link to chromosome band 16p13]
Location_base_pair Starts at 810765 and ends at 818865 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)MSLN   7371
Cards
Entrez_Gene (NCBI)MSLN  10232  mesothelin
AliasesMPF; SMRP
GeneCards (Weizmann)MSLN
Ensembl hg19 (Hinxton)ENSG00000102854 [Gene_View]  chr16:810765-818865 [Contig_View]  MSLN [Vega]
Ensembl hg38 (Hinxton)ENSG00000102854 [Gene_View]  chr16:810765-818865 [Contig_View]  MSLN [Vega]
ICGC DataPortalENSG00000102854
TCGA cBioPortalMSLN
AceView (NCBI)MSLN
Genatlas (Paris)MSLN
WikiGenes10232
SOURCE (Princeton)MSLN
Genetics Home Reference (NIH)MSLN
Genomic and cartography
GoldenPath hg19 (UCSC)MSLN  -     chr16:810765-818865 +  16p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MSLN  -     16p13.3   [Description]    (hg38-Dec_2013)
EnsemblMSLN - 16p13.3 [CytoView hg19]  MSLN - 16p13.3 [CytoView hg38]
Mapping of homologs : NCBIMSLN [Mapview hg19]  MSLN [Mapview hg38]
OMIM601051   
Gene and transcription
Genbank (Entrez)AF180951 AL545401 AY743922 BC003512 BC009272
RefSeq transcript (Entrez)NM_001177355 NM_005823 NM_013404
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010393 NW_004929400
Consensus coding sequences : CCDS (NCBI)MSLN
Cluster EST : UnigeneHs.408488 [ NCBI ]
CGAP (NCI)Hs.408488
Alternative Splicing GalleryENSG00000102854
Gene ExpressionMSLN [ NCBI-GEO ]   MSLN [ EBI - ARRAY_EXPRESS ]   MSLN [ SEEK ]   MSLN [ MEM ]
Gene Expression Viewer (FireBrowse)MSLN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10232
GTEX Portal (Tissue expression)MSLN
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13421   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13421  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13421
Splice isoforms : SwissVarQ13421
PhosPhoSitePlusQ13421
Domains : Interpro (EBI)Mesothelin    Stereocilin-rel   
Domain families : Pfam (Sanger)Mesothelin (PF06060)   
Domain families : Pfam (NCBI)pfam06060   
Conserved Domain (NCBI)MSLN
DMDM Disease mutations10232
Blocks (Seattle)MSLN
PDB (SRS)4F3F   
PDB (PDBSum)4F3F   
PDB (IMB)4F3F   
PDB (RSDB)4F3F   
Structural Biology KnowledgeBase4F3F   
SCOP (Structural Classification of Proteins)4F3F   
CATH (Classification of proteins structures)4F3F   
SuperfamilyQ13421
Human Protein AtlasENSG00000102854
Peptide AtlasQ13421
HPRD03030
IPIIPI00793522   IPI00793649   IPI00025110   IPI00798210   
Protein Interaction databases
DIP (DOE-UCLA)Q13421
IntAct (EBI)Q13421
FunCoupENSG00000102854
BioGRIDMSLN
STRING (EMBL)MSLN
ZODIACMSLN
Ontologies - Pathways
QuickGOQ13421
Ontology : AmiGOprotein binding  extracellular space  Golgi apparatus  plasma membrane  cell adhesion  cell-matrix adhesion  cell surface  membrane  pancreas development  anchored component of membrane  
Ontology : EGO-EBIprotein binding  extracellular space  Golgi apparatus  plasma membrane  cell adhesion  cell-matrix adhesion  cell surface  membrane  pancreas development  anchored component of membrane  
NDEx NetworkMSLN
Atlas of Cancer Signalling NetworkMSLN
Wikipedia pathwaysMSLN
Orthology - Evolution
OrthoDB10232
GeneTree (enSembl)ENSG00000102854
Phylogenetic Trees/Animal Genes : TreeFamMSLN
HOVERGENQ13421
HOGENOMQ13421
Homologs : HomoloGeneMSLN
Homology/Alignments : Family Browser (UCSC)MSLN
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMSLN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MSLN
dbVarMSLN
ClinVarMSLN
1000_GenomesMSLN 
Exome Variant ServerMSLN
ExAC (Exome Aggregation Consortium)MSLN (select the gene name)
Genetic variants : HAPMAP10232
Genomic Variants (DGV)MSLN [DGVbeta]
DECIPHER (Syndromes)16:810765-818865  ENSG00000102854
CONAN: Copy Number AnalysisMSLN 
Mutations
ICGC Data PortalMSLN 
TCGA Data PortalMSLN 
Broad Tumor PortalMSLN
OASIS PortalMSLN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMSLN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMSLN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MSLN
DgiDB (Drug Gene Interaction Database)MSLN
DoCM (Curated mutations)MSLN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MSLN (select a term)
intoGenMSLN
Cancer3DMSLN(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601051   
Orphanet
MedgenMSLN
Genetic Testing Registry MSLN
NextProtQ13421 [Medical]
TSGene10232
GENETestsMSLN
Huge Navigator MSLN [HugePedia]
snp3D : Map Gene to Disease10232
BioCentury BCIQMSLN
ClinGenMSLN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10232
Chemical/Pharm GKB GenePA31176
Clinical trialMSLN
Miscellaneous
canSAR (ICR)MSLN (select the gene name)
Probes
Litterature
PubMed120 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMSLN
EVEXMSLN
GoPubMedMSLN
iHOPMSLN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:11:08 CEST 2017

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