Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MSRB2 (methionine sulfoxide reductase B2)

Identity

Alias_namesMSRB
methionine sulfoxide reductase B
Alias_symbol (synonym)PILB
CGI-131
CBS1
CBS-1
Other alias
HGNC (Hugo) MSRB2
LocusID (NCBI) 22921
Atlas_Id 43001
Location 10p12.2  [Link to chromosome band 10p12]
Location_base_pair Starts at 23095498 and ends at 23122013 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MSRB2 (10p12.2) / MALRD1 (10p12.31)MSRB2 10p12.2 C10orf112

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;10)(p12;p12) MSRB2/MALRD1

External links

Nomenclature
HGNC (Hugo)MSRB2   17061
Cards
Entrez_Gene (NCBI)MSRB2  22921  methionine sulfoxide reductase B2
AliasesCBS-1; CBS1; CGI-131; MSRB; 
PILB
GeneCards (Weizmann)MSRB2
Ensembl hg19 (Hinxton)ENSG00000148450 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148450 [Gene_View]  ENSG00000148450 [Sequence]  chr10:23095498-23122013 [Contig_View]  MSRB2 [Vega]
ICGC DataPortalENSG00000148450
TCGA cBioPortalMSRB2
AceView (NCBI)MSRB2
Genatlas (Paris)MSRB2
WikiGenes22921
SOURCE (Princeton)MSRB2
Genetics Home Reference (NIH)MSRB2
Genomic and cartography
GoldenPath hg38 (UCSC)MSRB2  -     chr10:23095498-23122013 +  10p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MSRB2  -     10p12.2   [Description]    (hg19-Feb_2009)
EnsemblMSRB2 - 10p12.2 [CytoView hg19]  MSRB2 - 10p12.2 [CytoView hg38]
Mapping of homologs : NCBIMSRB2 [Mapview hg19]  MSRB2 [Mapview hg38]
OMIM613782   
Gene and transcription
Genbank (Entrez)AF122004 AF151889 BC018030 BC066305 BC117471
RefSeq transcript (Entrez)NM_012228
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MSRB2
Cluster EST : UnigeneHs.461420 [ NCBI ]
CGAP (NCI)Hs.461420
Alternative Splicing GalleryENSG00000148450
Gene ExpressionMSRB2 [ NCBI-GEO ]   MSRB2 [ EBI - ARRAY_EXPRESS ]   MSRB2 [ SEEK ]   MSRB2 [ MEM ]
Gene Expression Viewer (FireBrowse)MSRB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22921
GTEX Portal (Tissue expression)MSRB2
Human Protein AtlasENSG00000148450-MSRB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3D2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3D2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3D2
Splice isoforms : SwissVarQ9Y3D2
Catalytic activity : Enzyme1.8.4.- [ Enzyme-Expasy ]   1.8.4.-1.8.4.- [ IntEnz-EBI ]   1.8.4.- [ BRENDA ]   1.8.4.- [ KEGG ]   
PhosPhoSitePlusQ9Y3D2
Domaine pattern : Prosite (Expaxy)MSRB (PS51790)   
Domains : Interpro (EBI)Met_Sox_Rdtase    Met_Sox_Rdtase_MsrB    Mss4-like   
Domain families : Pfam (Sanger)SelR (PF01641)   
Domain families : Pfam (NCBI)pfam01641   
Conserved Domain (NCBI)MSRB2
DMDM Disease mutations22921
Blocks (Seattle)MSRB2
SuperfamilyQ9Y3D2
Human Protein Atlas [tissue]ENSG00000148450-MSRB2 [tissue]
Peptide AtlasQ9Y3D2
HPRD17606
IPIIPI00743141   IPI00032871   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3D2
IntAct (EBI)Q9Y3D2
FunCoupENSG00000148450
BioGRIDMSRB2
STRING (EMBL)MSRB2
ZODIACMSRB2
Ontologies - Pathways
QuickGOQ9Y3D2
Ontology : AmiGODNA binding transcription factor activity  actin binding  mitochondrion  cytosol  regulation of transcription, DNA-templated  response to oxidative stress  zinc ion binding  actin filament polymerization  protein repair  protein repair  peptide-methionine (R)-S-oxide reductase activity  peptide-methionine (R)-S-oxide reductase activity  L-methionine-(R)-S-oxide reductase activity  oxidation-reduction process  
Ontology : EGO-EBIDNA binding transcription factor activity  actin binding  mitochondrion  cytosol  regulation of transcription, DNA-templated  response to oxidative stress  zinc ion binding  actin filament polymerization  protein repair  protein repair  peptide-methionine (R)-S-oxide reductase activity  peptide-methionine (R)-S-oxide reductase activity  L-methionine-(R)-S-oxide reductase activity  oxidation-reduction process  
NDEx NetworkMSRB2
Atlas of Cancer Signalling NetworkMSRB2
Wikipedia pathwaysMSRB2
Orthology - Evolution
OrthoDB22921
GeneTree (enSembl)ENSG00000148450
Phylogenetic Trees/Animal Genes : TreeFamMSRB2
HOVERGENQ9Y3D2
HOGENOMQ9Y3D2
Homologs : HomoloGeneMSRB2
Homology/Alignments : Family Browser (UCSC)MSRB2
Gene fusions - Rearrangements
Fusion : MitelmanMSRB2/MALRD1 [10p12.2/10p12.31]  
Fusion PortalMSRB2 10p12.2 C10orf112 BRCA
Fusion : QuiverMSRB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMSRB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MSRB2
dbVarMSRB2
ClinVarMSRB2
1000_GenomesMSRB2 
Exome Variant ServerMSRB2
ExAC (Exome Aggregation Consortium)ENSG00000148450
GNOMAD BrowserENSG00000148450
Genetic variants : HAPMAP22921
Genomic Variants (DGV)MSRB2 [DGVbeta]
DECIPHERMSRB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMSRB2 
Mutations
ICGC Data PortalMSRB2 
TCGA Data PortalMSRB2 
Broad Tumor PortalMSRB2
OASIS PortalMSRB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMSRB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMSRB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MSRB2
DgiDB (Drug Gene Interaction Database)MSRB2
DoCM (Curated mutations)MSRB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MSRB2 (select a term)
intoGenMSRB2
Cancer3DMSRB2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM613782   
Orphanet
DisGeNETMSRB2
MedgenMSRB2
Genetic Testing Registry MSRB2
NextProtQ9Y3D2 [Medical]
TSGene22921
GENETestsMSRB2
Target ValidationMSRB2
Huge Navigator MSRB2 [HugePedia]
snp3D : Map Gene to Disease22921
BioCentury BCIQMSRB2
ClinGenMSRB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22921
Chemical/Pharm GKB GenePA134979691
Clinical trialMSRB2
Miscellaneous
canSAR (ICR)MSRB2 (select the gene name)
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMSRB2
EVEXMSRB2
GoPubMedMSRB2
iHOPMSRB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:38:42 CEST 2018
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