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MSTN (myostatin)

Identity

Other namesGDF8
MSLHP
HGNC (Hugo) MSTN
LocusID (NCBI) 2660
Location 2q32.2
Location_base_pair Starts at 190920426 and ends at 190927455 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MSTN   4223
Cards
Entrez_Gene (NCBI)MSTN  2660  myostatin
GeneCards (Weizmann)MSTN
Ensembl (Hinxton)ENSG00000138379 [Gene_View]  chr2:190920426-190927455 [Contig_View]  MSTN [Vega]
ICGC DataPortalENSG00000138379
AceView (NCBI)MSTN
Genatlas (Paris)MSTN
WikiGenes2660
SOURCE (Princeton)NM_005259
Genomic and cartography
GoldenPath (UCSC)MSTN  -  2q32.2   chr2:190920426-190927455 -  2q32.2   [Description]    (hg19-Feb_2009)
EnsemblMSTN - 2q32.2 [CytoView]
Mapping of homologs : NCBIMSTN [Mapview]
OMIM601788   614160   
Gene and transcription
Genbank (Entrez)AF019627 AF104922 AK291524 BC074757 BX093210
RefSeq transcript (Entrez)NM_005259
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_009800 NT_005403 NW_001838863 NW_004929305
Consensus coding sequences : CCDS (NCBI)MSTN
Cluster EST : UnigeneHs.41565 [ NCBI ]
CGAP (NCI)Hs.41565
Alternative Splicing : Fast-db (Paris)GSHG0018223
Alternative Splicing GalleryENSG00000138379
Gene ExpressionMSTN [ NCBI-GEO ]     MSTN [ SEEK ]   MSTN [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14793 (Uniprot)
NextProtO14793  [Medical]
With graphics : InterProO14793
Splice isoforms : SwissVarO14793 (Swissvar)
Domaine pattern : Prosite (Expaxy)TGF_BETA_1 (PS00250)    TGF_BETA_2 (PS51362)   
Domains : Interpro (EBI)Cystine-knot_cytokine    GDF_8    TGF-b_C    TGF-b_N    TGF-beta-rel    TGFb_CS   
Related proteins : CluSTrO14793
Domain families : Pfam (Sanger)TGF_beta (PF00019)    TGFb_propeptide (PF00688)   
Domain families : Pfam (NCBI)pfam00019    pfam00688   
Domain families : Smart (EMBL)TGFB (SM00204)  
DMDM Disease mutations2660
Blocks (Seattle)O14793
Human Protein AtlasENSG00000138379
Peptide AtlasO14793
HPRD03474
IPIIPI00023751   
Protein Interaction databases
DIP (DOE-UCLA)O14793
IntAct (EBI)O14793
FunCoupENSG00000138379
BioGRIDMSTN
InParanoidO14793
Interologous Interaction database O14793
IntegromeDBMSTN
STRING (EMBL)MSTN
Ontologies - Pathways
Ontology : AmiGOreceptor binding  receptor binding  cytokine activity  protein binding  extracellular space  cytoplasm  transforming growth factor beta receptor signaling pathway  muscle organ development  growth factor activity  heparin binding  response to heat  response to gravity  skeletal muscle atrophy  negative regulation of muscle hypertrophy  response to muscle activity  ovulation cycle process  response to testosterone  identical protein binding  skeletal muscle tissue regeneration  response to estrogen  response to ethanol  positive regulation of transcription, DNA-templated  negative regulation of skeletal muscle tissue growth  response to glucocorticoid  response to electrical stimulus  
Ontology : EGO-EBIreceptor binding  receptor binding  cytokine activity  protein binding  extracellular space  cytoplasm  transforming growth factor beta receptor signaling pathway  muscle organ development  growth factor activity  heparin binding  response to heat  response to gravity  skeletal muscle atrophy  negative regulation of muscle hypertrophy  response to muscle activity  ovulation cycle process  response to testosterone  identical protein binding  skeletal muscle tissue regeneration  response to estrogen  response to ethanol  positive regulation of transcription, DNA-templated  negative regulation of skeletal muscle tissue growth  response to glucocorticoid  response to electrical stimulus  
Protein Interaction DatabaseMSTN
Wikipedia pathwaysMSTN
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MSTN
SNP (GeneSNP Utah)MSTN
SNP : HGBaseMSTN
Genetic variants : HAPMAPMSTN
1000_GenomesMSTN 
ICGC programENSG00000138379 
CONAN: Copy Number AnalysisMSTN 
Somatic Mutations in Cancer : COSMICMSTN 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDMSTN
OMIM601788    614160   
MedgenMSTN
GENETestsMSTN
Disease Genetic AssociationMSTN
Huge Navigator MSTN [HugePedia]  MSTN [HugeCancerGEM]
Genomic VariantsMSTN  MSTN [DGVbeta]
Exome VariantMSTN
dbVarMSTN
ClinVarMSTN
snp3D : Map Gene to Disease2660
General knowledge
Homologs : HomoloGeneMSTN
Homology/Alignments : Family Browser (UCSC)MSTN
Phylogenetic Trees/Animal Genes : TreeFamMSTN
Chemical/Protein Interactions : CTD2660
Chemical/Pharm GKB GenePA162396253
Clinical trialMSTN
Cancer Resource (Charite)ENSG00000138379
Other databases
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
CoreMineMSTN
iHOPMSTN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 13:02:07 CEST 2014

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