MSTN (myostatin)

2004-02-01  

Identity

HGNC
LOCATION
2q32.2
LOCUSID
ALIAS
GDF8,MSLHP

Other Information

Locus ID:

NCBI: 2660
MIM: 601788
HGNC: 4223
Ensembl: ENSG00000138379

Variants:

dbSNP: 2660
ClinVar: 2660
TCGA: ENSG00000138379
COSMIC: MSTN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138379ENST00000260950O14793
ENSG00000138379ENST00000260950Q53S46

Expression (GTEx)

0
1
2
3
4

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152154842004Myostatin mutation associated with gross muscle hypertrophy in a child.327
121949802002The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum.130
178232962007Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle.119
182409722008Human sarcopenia reveals an increase in SOCS-3 and myostatin and a reduced efficiency of Akt phosphorylation.83
188359292009Increased secretion and expression of myostatin in skeletal muscle from extremely obese women.75
273045122016Quantification of GDF11 and Myostatin in Human Aging and Cardiovascular Disease.60
181758042008Identification of a novel pool of extracellular pro-myostatin in skeletal muscle.55
168496342006GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle.54
270342752016Biochemistry and Biology of GDF11 and Myostatin: Similarities, Differences, and Questions for Future Investigation.53
241454312013Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB-mediated mechanism.49

Citation

Dessen P

MSTN (myostatin)

Atlas Genet Cytogenet Oncol Haematol. 2004-02-01

Online version: http://atlasgeneticsoncology.org/gene/40703/mstn