| Nomenclature |
|---|
| HGNC (Hugo) | MSX1 7391 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MSX1 4487 msh homeobox 1 |
| Aliases | ECTD3; HOX7; HYD1; STHAG1 |
| GeneCards (Weizmann) | MSX1 |
| Ensembl hg19 (Hinxton) | ENSG00000163132 [Gene_View] chr4:4861392-4865660 [Contig_View] MSX1 [Vega] |
| Ensembl hg38 (Hinxton) | ENSG00000163132 [Gene_View] chr4:4861392-4865660 [Contig_View] MSX1 [Vega] |
| ICGC DataPortal | ENSG00000163132 |
| TCGA cBioPortal | MSX1 |
| AceView (NCBI) | MSX1 |
| Genatlas (Paris) | MSX1 |
| WikiGenes | 4487 |
| SOURCE (Princeton) | MSX1 |
| Genomic and cartography |
|---|
| GoldenPath hg19 (UCSC) | MSX1 - chr4:4861392-4865660 + 4p16.2 [Description] (hg19-Feb_2009) |
| GoldenPath hg38 (UCSC) | MSX1 - 4p16.2 [Description] (hg38-Dec_2013) |
| Ensembl | MSX1 - 4p16.2 [CytoView hg19] MSX1 - 4p16.2 [CytoView hg38] |
| Mapping of homologs : NCBI | MSX1 [Mapview hg19] MSX1 [Mapview hg38] |
| OMIM | 106600 142983 189500 608874 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK290636 AU117561 BC021285 BC067353 BU624994 |
| RefSeq transcript (Entrez) | NM_002448 |
| RefSeq genomic (Entrez) | NC_000004 NC_018915 NG_008121 NT_006051 NW_004929314 |
| Consensus coding sequences : CCDS (NCBI) | MSX1 |
| Cluster EST : Unigene | Hs.424414 [ NCBI ] |
| CGAP (NCI) | Hs.424414 |
| Alternative Splicing Gallery | ENSG00000163132 |
| Gene Expression | MSX1 [ NCBI-GEO ] MSX1 [ EBI - ARRAY_EXPRESS ]
MSX1 [ SEEK ] MSX1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MSX1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4487 |
| GTEX Portal (Tissue expression) | MSX1 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P28360 (Uniprot) |
| NextProt | P28360 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P28360 |
| Splice isoforms : SwissVar | P28360 (Swissvar) |
| PhosPhoSitePlus | P28360 |
| Domaine pattern : Prosite (Expaxy) | HOMEOBOX_1 (PS00027) HOMEOBOX_2 (PS50071) |
| Domains : Interpro (EBI) | Homeobox_CS Homeobox_dom Homeobox_metazoa Homeodomain-like |
| Domain families : Pfam (Sanger) | Homeobox (PF00046) |
| Domain families : Pfam (NCBI) | pfam00046 |
| Domain families : Smart (EMBL) | HOX (SM00389) |
| DMDM Disease mutations | 4487 |
| Blocks (Seattle) | MSX1 |
| Superfamily | P28360 |
| Human Protein Atlas | ENSG00000163132 |
| Peptide Atlas | P28360 |
| HPRD | 00866 |
| IPI | IPI01021380 IPI00002939 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P28360 |
| IntAct (EBI) | P28360 |
| FunCoup | ENSG00000163132 |
| BioGRID | MSX1 |
| STRING (EMBL) | MSX1 |
| ZODIAC | MSX1 |
| Ontologies - Pathways |
|---|
| QuickGO | P28360 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development p53 binding epithelial to mesenchymal transition involved in endocardial cushion formation nucleus nucleoplasm cytoplasm transcription from RNA polymerase II promoter muscle organ development negative regulation of cell proliferation anterior/posterior pattern specification mesenchymal cell proliferation signal transduction involved in regulation of gene expression negative regulation of cell growth positive regulation of BMP signaling pathway forebrain development midbrain development protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth regulation of odontogenesis negative regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription from RNA polymerase II promoter protein stabilization negative regulation of striated muscle cell differentiation palate development face morphogenesis bone morphogenesis cartilage morphogenesis mammary gland epithelium development BMP signaling pathway involved in heart development activation of meiosis positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development p53 binding epithelial to mesenchymal transition involved in endocardial cushion formation nucleus nucleoplasm cytoplasm transcription from RNA polymerase II promoter muscle organ development negative regulation of cell proliferation anterior/posterior pattern specification mesenchymal cell proliferation signal transduction involved in regulation of gene expression negative regulation of cell growth positive regulation of BMP signaling pathway forebrain development midbrain development protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic nail plate morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth regulation of odontogenesis negative regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription from RNA polymerase II promoter protein stabilization negative regulation of striated muscle cell differentiation palate development face morphogenesis bone morphogenesis cartilage morphogenesis mammary gland epithelium development BMP signaling pathway involved in heart development activation of meiosis positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process |
| Pathways : KEGG | HTLV-I infection |
| NDEx Network | MSX1 |
| Atlas of Cancer Signalling Network | MSX1 |
| Wikipedia pathways | MSX1 |
| Orthology - Evolution |
|---|
| OrthoDB | 4487 |
| GeneTree (enSembl) | ENSG00000163132 |
| Phylogenetic Trees/Animal Genes : TreeFam | MSX1 |
| Homologs : HomoloGene | MSX1 |
| Homology/Alignments : Family Browser (UCSC) | MSX1 |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP, variants |
|---|
| NCBI Variation Viewer | MSX1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MSX1 |
| dbVar | MSX1 |
| ClinVar | MSX1 |
| 1000_Genomes | MSX1 |
| Exome Variant Server | MSX1 |
| ExAC (Exome Aggregation Consortium) | MSX1 (select the gene name) |
| Genetic variants : HAPMAP | 4487 |
| Genomic Variants (DGV) | MSX1 [DGVbeta] |
| Mutations |
|---|
| ICGC Data Portal | MSX1 |
| TCGA Data Portal | MSX1 |
| Broad Tumor Portal | MSX1 |
| OASIS Portal | MSX1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | MSX1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search MSX1 |
| DgiDB (Drug Gene Interaction Database) | MSX1 |
| DoCM (Curated mutations) | MSX1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MSX1 (select a term) |
| intoGen | MSX1 |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] |
| Diseases |
|---|
| DECIPHER (Syndromes) | 4:4861392-4865660 ENSG00000163132 |
| CONAN: Copy Number Analysis | MSX1 |
| Mutations and Diseases : HGMD | MSX1 |
| OMIM | 106600 142983 189500 608874 |
| Medgen | MSX1 |
| Genetic Testing Registry | MSX1
|
| NextProt | P28360 [Medical] |
| TSGene | 4487 |
| GENETests | MSX1 |
| Huge Navigator |
MSX1 [HugePedia] |
| snp3D : Map Gene to Disease | 4487 |
| BioCentury BCIQ | MSX1 |
| ClinGen | MSX1 |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 4487 |
| Chemical/Pharm GKB Gene | PA31196 |
| Clinical trial | MSX1 |
| Miscellaneous |
|---|
| canSAR (ICR) | MSX1 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 113 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | MSX1 |
| EVEX | MSX1 |
| GoPubMed | MSX1 |
| iHOP | MSX1 |
