Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MSX1 (msh homeobox 1)

Identity

Other namesECTD3
HOX7
HYD1
STHAG1
HGNC (Hugo) MSX1
LocusID (NCBI) 4487
Location 4p16.2
Location_base_pair Starts at 4861392 and ends at 4865660 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

External links

Nomenclature
HGNC (Hugo)MSX1   7391
Entrez_Gene (NCBI)MSX1  4487  msh homeobox 1
Cards
GeneCards (Weizmann)MSX1
Ensembl (Hinxton)ENSG00000163132 [Gene_View]  chr4:4861392-4865660 [Contig_View]  MSX1 [Vega]
AceView (NCBI)MSX1
Genatlas (Paris)MSX1
SOURCE (Stanford)NM_002448
Genomic and cartography
GoldenPath (UCSC)MSX1  -  4p16.2   chr4:4861392-4865660 +  4p16.2   [Description]    (hg19-Feb_2009)
EnsemblMSX1 - 4p16.2 [CytoView]
Mapping of homologs : NCBIMSX1 [Mapview]
OMIM106600   142983   189500   608874   
Gene and transcription
Genbank (Entrez)AK290636 AU117561 BC021285 BC067353 BU624994
RefSeq transcript (SRS)NM_002448
RefSeq transcript (Entrez)NM_002448
RefSeq genomic (SRS)AC_000136 NC_000004 NC_018915 NG_008121 NT_006051 NW_001838897 NW_004929314
RefSeq genomic (Entrez)AC_000136 NC_000004 NC_018915 NG_008121 NT_006051 NW_001838897 NW_004929314
Consensus coding sequences : CCDS (NCBI)MSX1
Cluster EST : UnigeneHs.424414 [ SRS ] Hs.424414 [ NCBI ]
CGAP (NCI)Hs.424414
Alternative Splicing : Fast-db (Paris)GSHG0022438
Alternative Splicing GalleryENSG00000163132
Gene ExpressionMSX1 [ NCBI-GEO ]   MSX1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28360 (SRS) P28360 (Uniprot)
NextProtP28360  [Medical]
With graphics : InterProP28360
Splice isoforms : SwissVarP28360(Swissvar)
Domaine pattern : Prosite (SRS)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (SRS)Homeobox_CS    Homeobox_dom    Homeobox_metazoa    Homeodomain-like   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeobox_metazoa    Homeodomain-like   
Related proteins : CluSTrP28360
Domain families : Pfam (SRS)Homeobox (PF00046)   
Domain families : Pfam (Sanger)Homeobox (PF00046)   
Domain families : Pfam (NCBI)pfam00046   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM4487
Blocks (Seattle)P28360
Human Protein AtlasENSG00000163132
HPRD00866
IPIIPI01021380   IPI00002939   
Protein Interaction databases
DIP (DOE-UCLA)P28360
IntAct (EBI)P28360
FunCoupENSG00000163132
REACTOMEMSX1
Protein Interaction Database4487
BioGRIDMSX1
InParanoidP28360
Interologous Interaction database P28360
IntegromeDBMSX1
Gene fusion - rearrangments
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MSX1
SNP (GeneSNP Utah)MSX1
SNP : HGBaseMSX1
Genetic variants : HAPMAPMSX1
Somatic Mutations in Cancer : COSMICMSX1 
CONAN: Copy Number AnalysisMSX1 
Mutations and Diseases : HGMDMSX1
OMIM106600    142983    189500    608874   
GENETests106600    142983    189500    608874   
Disease Genetic AssociationMSX1
Huge Navigator MSX1 [HugePedia]  MSX1 [HugeCancerGEM]
Genomic VariantsMSX1  MSX1 [DGVbeta]
ClinVarMSX1
snp3D : Map Gene to Disease4487
General knowledge
Homologs : HomoloGeneMSX1
Homology/Alignments : Family Browser (UCSC)MSX1
Phylogenetic Trees/Animal Genes : TreeFamMSX1
Chemical/Protein Interactions : CTD4487
Chemical/Pharm GKB GenePA31196
Clinical trialMSX1
Cancer Resource (Charite)ENSG00000163132
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  cell morphogenesis  p53 binding  sequence-specific DNA binding transcription factor activity  nucleus  transcription, DNA-templated  apoptotic nuclear changes  negative regulation of cell growth  protein localization to nucleus  negative regulation of histone acetylation  embryonic nail plate morphogenesis  odontogenesis of dentin-containing tooth  positive regulation of DNA damage response, signal transduction by p53 class mediator  sequence-specific DNA binding  protein stabilization  face morphogenesis  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  cell morphogenesis  p53 binding  sequence-specific DNA binding transcription factor activity  nucleus  transcription, DNA-templated  apoptotic nuclear changes  negative regulation of cell growth  protein localization to nucleus  negative regulation of histone acetylation  embryonic nail plate morphogenesis  odontogenesis of dentin-containing tooth  positive regulation of DNA damage response, signal transduction by p53 class mediator  sequence-specific DNA binding  protein stabilization  face morphogenesis  positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator  
Other databases
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
PubGeneMSX1
iHOPMSX1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Dec 3 20:05:02 CET 2013
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