| Nomenclature |
|---|
| HGNC (Hugo) | MSX1 7391 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MSX1 4487 msh homeobox 1 |
| Aliases | ECTD3; HOX7; HYD1; STHAG1 |
| GeneCards (Weizmann) | MSX1 |
| Ensembl hg19 (Hinxton) | ENSG00000163132 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000163132 [Gene_View] chr4:4859665-4863933 [Contig_View] MSX1 [Vega] |
| ICGC DataPortal | ENSG00000163132 |
| TCGA cBioPortal | MSX1 |
| AceView (NCBI) | MSX1 |
| Genatlas (Paris) | MSX1 |
| WikiGenes | 4487 |
| SOURCE (Princeton) | MSX1 |
| Genetics Home Reference (NIH) | MSX1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MSX1 - chr4:4859665-4863933 + 4p16.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MSX1 - 4p16.2 [Description] (hg19-Feb_2009) |
| Ensembl | MSX1 - 4p16.2 [CytoView hg19] MSX1 - 4p16.2 [CytoView hg38] |
| Mapping of homologs : NCBI | MSX1 [Mapview hg19] MSX1 [Mapview hg38] |
| OMIM | 106600 142983 189500 608874 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK290636 AU117561 BC021285 BC067353 BU624994 |
| RefSeq transcript (Entrez) | NM_002448 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | MSX1 |
| Cluster EST : Unigene | Hs.424414 [ NCBI ] |
| CGAP (NCI) | Hs.424414 |
| Alternative Splicing Gallery | ENSG00000163132 |
| Gene Expression | MSX1 [ NCBI-GEO ] MSX1 [ EBI - ARRAY_EXPRESS ]
MSX1 [ SEEK ] MSX1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MSX1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4487 |
| GTEX Portal (Tissue expression) | MSX1 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P28360 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P28360 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P28360 |
| Splice isoforms : SwissVar | P28360 |
| PhosPhoSitePlus | P28360 |
| Domaine pattern : Prosite (Expaxy) | HOMEOBOX_1 (PS00027) HOMEOBOX_2 (PS50071) |
| Domains : Interpro (EBI) | Homeobox-like Homeobox_CS Homeobox_dom Homeobox_metazoa |
| Domain families : Pfam (Sanger) | Homeobox (PF00046) |
| Domain families : Pfam (NCBI) | pfam00046 |
| Domain families : Smart (EMBL) | HOX (SM00389) |
| Conserved Domain (NCBI) | MSX1 |
| DMDM Disease mutations | 4487 |
| Blocks (Seattle) | MSX1 |
| Superfamily | P28360 |
| Human Protein Atlas | ENSG00000163132 |
| Peptide Atlas | P28360 |
| HPRD | 00866 |
| IPI | IPI01021380 IPI00002939 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P28360 |
| IntAct (EBI) | P28360 |
| FunCoup | ENSG00000163132 |
| BioGRID | MSX1 |
| STRING (EMBL) | MSX1 |
| ZODIAC | MSX1 |
| Ontologies - Pathways |
|---|
| QuickGO | P28360 |
| Ontology : AmiGO | negative regulation of transcription from RNA polymerase II promoter cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development p53 binding epithelial to mesenchymal transition involved in endocardial cushion formation nucleus nucleoplasm transcription from RNA polymerase II promoter muscle organ development negative regulation of cell proliferation anterior/posterior pattern specification mesenchymal cell proliferation pituitary gland development signal transduction involved in regulation of gene expression negative regulation of cell growth positive regulation of BMP signaling pathway midbrain development protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis enhancer binding embryonic nail plate morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth regulation of odontogenesis negative regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription from RNA polymerase II promoter stem cell differentiation protein stabilization negative regulation of striated muscle cell differentiation palate development face morphogenesis bone morphogenesis cartilage morphogenesis mammary gland epithelium development BMP signaling pathway involved in heart development cellular response to nicotine activation of meiosis positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process |
| Ontology : EGO-EBI | negative regulation of transcription from RNA polymerase II promoter cell morphogenesis RNA polymerase II regulatory region sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding in utero embryonic development p53 binding epithelial to mesenchymal transition involved in endocardial cushion formation nucleus nucleoplasm transcription from RNA polymerase II promoter muscle organ development negative regulation of cell proliferation anterior/posterior pattern specification mesenchymal cell proliferation pituitary gland development signal transduction involved in regulation of gene expression negative regulation of cell growth positive regulation of BMP signaling pathway midbrain development protein localization to nucleus embryonic forelimb morphogenesis embryonic hindlimb morphogenesis enhancer binding embryonic nail plate morphogenesis middle ear morphogenesis odontogenesis of dentin-containing tooth regulation of odontogenesis negative regulation of apoptotic process positive regulation of DNA damage response, signal transduction by p53 class mediator positive regulation of transcription from RNA polymerase II promoter stem cell differentiation protein stabilization negative regulation of striated muscle cell differentiation palate development face morphogenesis bone morphogenesis cartilage morphogenesis mammary gland epithelium development BMP signaling pathway involved in heart development cellular response to nicotine activation of meiosis positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of transcription regulatory region DNA binding positive regulation of mesenchymal cell apoptotic process |
| Pathways : KEGG | HTLV-I infection |
| NDEx Network | MSX1 |
| Atlas of Cancer Signalling Network | MSX1 |
| Wikipedia pathways | MSX1 |
| Orthology - Evolution |
|---|
| OrthoDB | 4487 |
| GeneTree (enSembl) | ENSG00000163132 |
| Phylogenetic Trees/Animal Genes : TreeFam | MSX1 |
| HOVERGEN | P28360 |
| HOGENOM | P28360 |
| Homologs : HomoloGene | MSX1 |
| Homology/Alignments : Family Browser (UCSC) | MSX1 |
| Gene fusions - Rearrangements |
|---|
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MSX1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MSX1 |
| dbVar | MSX1 |
| ClinVar | MSX1 |
| 1000_Genomes | MSX1 |
| Exome Variant Server | MSX1 |
| ExAC (Exome Aggregation Consortium) | MSX1 (select the gene name) |
| Genetic variants : HAPMAP | 4487 |
| Genomic Variants (DGV) | MSX1 [DGVbeta] |
| DECIPHER | MSX1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MSX1 |
| Mutations |
|---|
| ICGC Data Portal | MSX1 |
| TCGA Data Portal | MSX1 |
| Broad Tumor Portal | MSX1 |
| OASIS Portal | MSX1 [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | MSX1 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | MSX1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search MSX1 |
| DgiDB (Drug Gene Interaction Database) | MSX1 |
| DoCM (Curated mutations) | MSX1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MSX1 (select a term) |
| intoGen | MSX1 |
| Cancer3D | MSX1(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 106600 142983 189500 608874 |
| Orphanet | 2102 14371 |
| Medgen | MSX1 |
| Genetic Testing Registry | MSX1
|
| NextProt | P28360 [Medical] |
| TSGene | 4487 |
| GENETests | MSX1 |
| Target Validation | MSX1 |
| Huge Navigator |
MSX1 [HugePedia] |
| snp3D : Map Gene to Disease | 4487 |
| BioCentury BCIQ | MSX1 |
| ClinGen | MSX1 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 4487 |
| Chemical/Pharm GKB Gene | PA31196 |
| Clinical trial | MSX1 |
| Miscellaneous |
|---|
| canSAR (ICR) | MSX1 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 125 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | MSX1 |
| EVEX | MSX1 |
| GoPubMed | MSX1 |
| iHOP | MSX1 |
