MT1H (metallothionein 1H)

2003-08-01 Affiliation

Identity

HGNC

MT1H

LOCATION

16q13

LOCUSID

4496

ALIAS

MT-0,MT-1H,MT-IH,MT1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4496
MIM: 156354
HGNC: 7400
Ensembl: ENSG00000205358

Variants:

dbSNP: 4496
ClinVar: 4496
TCGA: ENSG00000205358
COSMIC: MT1H

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000205358	ENST00000332374	P80294
ENSG00000205358	ENST00000332374	A0A140VJP7
ENSG00000205358	ENST00000569155	H3BTC4

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Mineral absorption	KEGG	ko04978
Mineral absorption	KEGG	hsa04978
Metabolism	REACTOME	R-HSA-1430728
Response to metal ions	REACTOME	R-HSA-5660526
Metallothioneins bind metals	REACTOME	R-HSA-5661231

References

Pubmed ID	Year	Title	Citations
12081484	2002	S-nitrosothiols react preferentially with zinc thiolate clusters of metallothionein III through transnitrosation.	16
20551211	2010	Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.	16
28241806	2017	Metallothionein 1H (MT1H) functions as a tumor suppressor in hepatocellular carcinoma through regulating Wnt/β-catenin signaling pathway.	9
24662736	2015	An epigenetic screen unmasks metallothioneins as putative contributors to renal cell carcinogenesis.	4
15747776	2003	Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line.	3

Citation

Dessen P

MT1H (metallothionein 1H)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41440/mt1h