MT2A (metallothionein 2A)

2003-08-01  

Identity

HGNC
LOCATION
16q13
LOCUSID
ALIAS
MT-2,MT-II,MT2
FUSION GENES

Other Information

Locus ID:

NCBI: 4502
MIM: 156360
HGNC: 7406
Ensembl: ENSG00000125148

Variants:

dbSNP: 4502
ClinVar: 4502
TCGA: ENSG00000125148
COSMIC: MT2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125148ENST00000245185P02795
ENSG00000125148ENST00000561491H3BSP9

Expression (GTEx)

0
500
1000
1500
2000
2500
3000
3500
4000

Pathways

PathwaySourceExternal ID
Mineral absorptionKEGGko04978
Mineral absorptionKEGGhsa04978
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon gamma signalingREACTOMER-HSA-877300
MetabolismREACTOMER-HSA-1430728
Response to metal ionsREACTOMER-HSA-5660526
Metallothioneins bind metalsREACTOMER-HSA-5661231

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
235539902013MiR-23a in amplified 19p13.13 loci targets metallothionein 2A and promotes growth in gastric cancer cells.26
127142542003Metallothioneins/PARP-1/IL-6 interplay on natural killer cell activity in elderly: parallelism with nonagenarians and old infected humans. Effect of zinc supply.24
161667382006The role of metallothionein in the pathogenesis of acute lung injury.24
211870892011Metallothionein-2A overexpression increases the expression of matrix metalloproteinase-9 and invasion of breast cancer cells.23
164029172006Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells.21
183491102008Polymorphisms in metallothionein-1 and -2 genes associated with the risk of type 2 diabetes mellitus and its complications.20
189963712009Restoring wtp53 activity in HIPK2 depleted MCF7 cells by modulating metallothionein and zinc.20
150412472004Metallothionein can function as a chaperone for zinc uptake transport into prostate and liver mitochondria.18
182086032008Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues.18

Citation

Dessen P

MT2A (metallothionein 2A)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/41441/mt2a