Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MT2A (metallothionein 2A)

Identity

Alias_namesMT2
Other alias
HGNC (Hugo) MT2A
LocusID (NCBI) 4502
Atlas_Id 41441
Location 16q13  [Link to chromosome band 16q13]
Location_base_pair Starts at 56608566 and ends at 56609497 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		FAM120A (9q22.31) / MT2A (16q12.2)MT2A (16q12.2) / CDK2 (12q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MT2A   7406
Cards
Entrez_Gene (NCBI)MT2A  4502  metallothionein 2A
AliasesMT2
GeneCards (Weizmann)MT2A
Ensembl hg19 (Hinxton)ENSG00000125148 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125148 [Gene_View]  chr16:56608566-56609497 [Contig_View]  MT2A [Vega]
ICGC DataPortalENSG00000125148
TCGA cBioPortalMT2A
AceView (NCBI)MT2A
Genatlas (Paris)MT2A
WikiGenes4502
SOURCE (Princeton)MT2A
Genetics Home Reference (NIH)MT2A
Genomic and cartography
GoldenPath hg38 (UCSC)MT2A  -     chr16:56608566-56609497 +  16q13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MT2A  -     16q13   [Description]    (hg19-Feb_2009)
EnsemblMT2A - 16q13 [CytoView hg19]  MT2A - 16q13 [CytoView hg38]
Mapping of homologs : NCBIMT2A [Mapview hg19]  MT2A [Mapview hg38]
OMIM156360   
Gene and transcription
Genbank (Entrez)BC007034 BC062435 BC070289 BM746626 BT007315
RefSeq transcript (Entrez)NM_005953
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MT2A
Cluster EST : UnigeneHs.534330 [ NCBI ]
CGAP (NCI)Hs.534330
Alternative Splicing GalleryENSG00000125148
Gene ExpressionMT2A [ NCBI-GEO ]   MT2A [ EBI - ARRAY_EXPRESS ]   MT2A [ SEEK ]   MT2A [ MEM ]
Gene Expression Viewer (FireBrowse)MT2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4502
GTEX Portal (Tissue expression)MT2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP02795   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP02795  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP02795
Splice isoforms : SwissVarP02795
PhosPhoSitePlusP02795
Domaine pattern : Prosite (Expaxy)METALLOTHIONEIN_VRT (PS00203)   
Domains : Interpro (EBI)Metalthion    Metalthion_dom    Metalthion_dom_vert    Metalthion_vert    Metalthion_vert_metal_BS   
Domain families : Pfam (Sanger)Metallothio (PF00131)   
Domain families : Pfam (NCBI)pfam00131   
Conserved Domain (NCBI)MT2A
DMDM Disease mutations4502
Blocks (Seattle)MT2A
PDB (SRS)1MHU    2MHU   
PDB (PDBSum)1MHU    2MHU   
PDB (IMB)1MHU    2MHU   
PDB (RSDB)1MHU    2MHU   
Structural Biology KnowledgeBase1MHU    2MHU   
SCOP (Structural Classification of Proteins)1MHU    2MHU   
CATH (Classification of proteins structures)1MHU    2MHU   
SuperfamilyP02795
Human Protein AtlasENSG00000125148
Peptide AtlasP02795
HPRD08863
IPIIPI00022498   
Protein Interaction databases
DIP (DOE-UCLA)P02795
IntAct (EBI)P02795
FunCoupENSG00000125148
BioGRIDMT2A
STRING (EMBL)MT2A
ZODIACMT2A
Ontologies - Pathways
QuickGOP02795
Ontology : AmiGOprotein binding  nucleus  cytoplasm  cytosol  cellular copper ion homeostasis  drug binding  zinc ion binding  zinc ion binding  response to metal ion  cellular response to drug  cellular response to interleukin-3  cellular response to erythropoietin  negative regulation of growth  perinuclear region of cytoplasm  interferon-gamma-mediated signaling pathway  cellular response to zinc ion  
Ontology : EGO-EBIprotein binding  nucleus  cytoplasm  cytosol  cellular copper ion homeostasis  drug binding  zinc ion binding  zinc ion binding  response to metal ion  cellular response to drug  cellular response to interleukin-3  cellular response to erythropoietin  negative regulation of growth  perinuclear region of cytoplasm  interferon-gamma-mediated signaling pathway  cellular response to zinc ion  
Pathways : KEGGMineral absorption   
NDEx NetworkMT2A
Atlas of Cancer Signalling NetworkMT2A
Wikipedia pathwaysMT2A
Orthology - Evolution
OrthoDB4502
GeneTree (enSembl)ENSG00000125148
Phylogenetic Trees/Animal Genes : TreeFamMT2A
HOVERGENP02795
HOGENOMP02795
Homologs : HomoloGeneMT2A
Homology/Alignments : Family Browser (UCSC)MT2A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMT2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MT2A
dbVarMT2A
ClinVarMT2A
1000_GenomesMT2A 
Exome Variant ServerMT2A
ExAC (Exome Aggregation Consortium)MT2A (select the gene name)
Genetic variants : HAPMAP4502
Genomic Variants (DGV)MT2A [DGVbeta]
DECIPHERMT2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMT2A 
Mutations
ICGC Data PortalMT2A 
TCGA Data PortalMT2A 
Broad Tumor PortalMT2A
OASIS PortalMT2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMT2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMT2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MT2A
DgiDB (Drug Gene Interaction Database)MT2A
DoCM (Curated mutations)MT2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MT2A (select a term)
intoGenMT2A
Cancer3DMT2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM156360   
Orphanet
MedgenMT2A
Genetic Testing Registry MT2A
NextProtP02795 [Medical]
TSGene4502
GENETestsMT2A
Target ValidationMT2A
Huge Navigator MT2A [HugePedia]
snp3D : Map Gene to Disease4502
BioCentury BCIQMT2A
ClinGenMT2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4502
Chemical/Pharm GKB GenePA31214
Clinical trialMT2A
Miscellaneous
canSAR (ICR)MT2A (select the gene name)
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMT2A
EVEXMT2A
GoPubMedMT2A
iHOPMT2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:45:30 CEST 2017
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