Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MT3 (metallothionein 3)

Identity

Alias_namesmetallothionein 3 (growth inhibitory factor (neurotrophic))
Alias_symbol (synonym)GIF
Other aliasGIFB
GRIF
ZnMT3
HGNC (Hugo) MT3
LocusID (NCBI) 4504
Atlas_Id 41442
Location 16q12.2  [Link to chromosome band 16q12]
Location_base_pair Starts at 56623267 and ends at 56625000 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MT3   7408
Cards
Entrez_Gene (NCBI)MT3  4504  metallothionein 3
AliasesGIF; GIFB; GRIF; ZnMT3
GeneCards (Weizmann)MT3
Ensembl hg19 (Hinxton)ENSG00000087250 [Gene_View]  chr16:56623267-56625000 [Contig_View]  MT3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000087250 [Gene_View]  chr16:56623267-56625000 [Contig_View]  MT3 [Vega]
ICGC DataPortalENSG00000087250
TCGA cBioPortalMT3
AceView (NCBI)MT3
Genatlas (Paris)MT3
WikiGenes4504
SOURCE (Princeton)MT3
Genetics Home Reference (NIH)MT3
Genomic and cartography
GoldenPath hg19 (UCSC)MT3  -     chr16:56623267-56625000 +  16q12.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MT3  -     16q12.2   [Description]    (hg38-Dec_2013)
EnsemblMT3 - 16q12.2 [CytoView hg19]  MT3 - 16q12.2 [CytoView hg38]
Mapping of homologs : NCBIMT3 [Mapview hg19]  MT3 [Mapview hg38]
OMIM139255   
Gene and transcription
Genbank (Entrez)BC013081 BC035624 BC047694 BI752092 BI820409
RefSeq transcript (Entrez)NM_005954
RefSeq genomic (Entrez)NC_000016 NC_018927 NT_010498 NW_004929402
Consensus coding sequences : CCDS (NCBI)MT3
Cluster EST : UnigeneHs.73133 [ NCBI ]
CGAP (NCI)Hs.73133
Alternative Splicing GalleryENSG00000087250
Gene ExpressionMT3 [ NCBI-GEO ]   MT3 [ EBI - ARRAY_EXPRESS ]   MT3 [ SEEK ]   MT3 [ MEM ]
Gene Expression Viewer (FireBrowse)MT3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4504
GTEX Portal (Tissue expression)MT3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25713   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25713  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25713
Splice isoforms : SwissVarP25713
PhosPhoSitePlusP25713
Domaine pattern : Prosite (Expaxy)METALLOTHIONEIN_VRT (PS00203)   
Domains : Interpro (EBI)Metalthion    Metalthion_dom    Metalthion_dom_vert    Metalthion_vert    Metalthion_vert_metal_BS   
Domain families : Pfam (Sanger)Metallothio (PF00131)   
Domain families : Pfam (NCBI)pfam00131   
Conserved Domain (NCBI)MT3
DMDM Disease mutations4504
Blocks (Seattle)MT3
PDB (SRS)2F5H    2FJ4    2FJ5   
PDB (PDBSum)2F5H    2FJ4    2FJ5   
PDB (IMB)2F5H    2FJ4    2FJ5   
PDB (RSDB)2F5H    2FJ4    2FJ5   
Structural Biology KnowledgeBase2F5H    2FJ4    2FJ5   
SCOP (Structural Classification of Proteins)2F5H    2FJ4    2FJ5   
CATH (Classification of proteins structures)2F5H    2FJ4    2FJ5   
SuperfamilyP25713
Human Protein AtlasENSG00000087250
Peptide AtlasP25713
HPRD00752
IPIIPI00016666   
Protein Interaction databases
DIP (DOE-UCLA)P25713
IntAct (EBI)P25713
FunCoupENSG00000087250
BioGRIDMT3
STRING (EMBL)MT3
ZODIACMT3
Ontologies - Pathways
QuickGOP25713
Ontology : AmiGOprotein import into nucleus, translocation  response to hypoxia  positive regulation of protein phosphorylation  copper ion binding  copper ion binding  protein binding  extracellular space  intracellular  cytoplasm  mitochondrial outer membrane  rough endoplasmic reticulum  cytosol  ribosome  microtubule  plasma membrane  energy reserve metabolic process  cholesterol catabolic process  zinc II ion transport  cellular metal ion homeostasis  cellular metal ion homeostasis  cellular zinc ion homeostasis  brain development  synaptic vesicle  drug binding  zinc ion binding  cell proliferation  response to metal ion  negative regulation of autophagy  positive regulation of gene expression  positive regulation of gene expression  positive regulation of necrotic cell death  positive regulation of cell death  positive regulation of cell death  astrocyte development  postsynaptic density  antioxidant activity  inclusion body  histone modification  removal of superoxide radicals  protein kinase activator activity  negative regulation of cell growth  negative regulation of cell growth  negative regulation of cell growth  axon  negative regulation of axon extension  positive regulation of vascular endothelial growth factor receptor signaling pathway  regulation of response to food  activation of protein kinase B activity  leptin-mediated signaling pathway  cellular response to oxidative stress  cellular response to drug  positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  positive regulation of catalytic activity  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  dendritic spine  protein kinase B signaling  negative regulation of neuron apoptotic process  cellular lipid catabolic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  cadmium ion binding  perinuclear region of cytoplasm  protein stabilization  negative regulation of oxidoreductase activity  zinc ion homeostasis  cadmium ion homeostasis  regulation of protein glycosylation  negative regulation of necrotic cell death  negative regulation of necrotic cell death  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to cadmium ion  cellular response to hypoxia  cellular response to nitric oxide  positive regulation of lysosomal membrane permeability  astrocyte end-foot  negative regulation of cysteine-type endopeptidase activity  negative regulation of hydrogen peroxide catabolic process  positive regulation of oxygen metabolic process  negative regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIprotein import into nucleus, translocation  response to hypoxia  positive regulation of protein phosphorylation  copper ion binding  copper ion binding  protein binding  extracellular space  intracellular  cytoplasm  mitochondrial outer membrane  rough endoplasmic reticulum  cytosol  ribosome  microtubule  plasma membrane  energy reserve metabolic process  cholesterol catabolic process  zinc II ion transport  cellular metal ion homeostasis  cellular metal ion homeostasis  cellular zinc ion homeostasis  brain development  synaptic vesicle  drug binding  zinc ion binding  cell proliferation  response to metal ion  negative regulation of autophagy  positive regulation of gene expression  positive regulation of gene expression  positive regulation of necrotic cell death  positive regulation of cell death  positive regulation of cell death  astrocyte development  postsynaptic density  antioxidant activity  inclusion body  histone modification  removal of superoxide radicals  protein kinase activator activity  negative regulation of cell growth  negative regulation of cell growth  negative regulation of cell growth  axon  negative regulation of axon extension  positive regulation of vascular endothelial growth factor receptor signaling pathway  regulation of response to food  activation of protein kinase B activity  leptin-mediated signaling pathway  cellular response to oxidative stress  cellular response to drug  positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress  cysteine-type endopeptidase inhibitor activity involved in apoptotic process  negative regulation of apoptotic process  positive regulation of catalytic activity  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  dendritic spine  protein kinase B signaling  negative regulation of neuron apoptotic process  cellular lipid catabolic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  cadmium ion binding  perinuclear region of cytoplasm  protein stabilization  negative regulation of oxidoreductase activity  zinc ion homeostasis  cadmium ion homeostasis  regulation of protein glycosylation  negative regulation of necrotic cell death  negative regulation of necrotic cell death  ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  positive regulation of ERK1 and ERK2 cascade  cellular response to cadmium ion  cellular response to hypoxia  cellular response to nitric oxide  positive regulation of lysosomal membrane permeability  astrocyte end-foot  negative regulation of cysteine-type endopeptidase activity  negative regulation of hydrogen peroxide catabolic process  positive regulation of oxygen metabolic process  negative regulation of reactive oxygen species metabolic process  
NDEx NetworkMT3
Atlas of Cancer Signalling NetworkMT3
Wikipedia pathwaysMT3
Orthology - Evolution
OrthoDB4504
GeneTree (enSembl)ENSG00000087250
Phylogenetic Trees/Animal Genes : TreeFamMT3
HOVERGENP25713
HOGENOMP25713
Homologs : HomoloGeneMT3
Homology/Alignments : Family Browser (UCSC)MT3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMT3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MT3
dbVarMT3
ClinVarMT3
1000_GenomesMT3 
Exome Variant ServerMT3
ExAC (Exome Aggregation Consortium)MT3 (select the gene name)
Genetic variants : HAPMAP4504
Genomic Variants (DGV)MT3 [DGVbeta]
DECIPHER (Syndromes)16:56623267-56625000  ENSG00000087250
CONAN: Copy Number AnalysisMT3 
Mutations
ICGC Data PortalMT3 
TCGA Data PortalMT3 
Broad Tumor PortalMT3
OASIS PortalMT3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMT3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMT3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MT3
DgiDB (Drug Gene Interaction Database)MT3
DoCM (Curated mutations)MT3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MT3 (select a term)
intoGenMT3
Cancer3DMT3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139255   
Orphanet
MedgenMT3
Genetic Testing Registry MT3
NextProtP25713 [Medical]
TSGene4504
GENETestsMT3
Huge Navigator MT3 [HugePedia]
snp3D : Map Gene to Disease4504
BioCentury BCIQMT3
ClinGenMT3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4504
Chemical/Pharm GKB GenePA31216
Clinical trialMT3
Miscellaneous
canSAR (ICR)MT3 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMT3
EVEXMT3
GoPubMedMT3
iHOPMT3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:17:33 CET 2017

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