Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MTA2 (metastasis associated 1 family member 2)

Identity

Alias_namesMTA1L1
metastasis associated gene family
Alias_symbol (synonym)MTA1-L1
Other aliasPID
HGNC (Hugo) MTA2
LocusID (NCBI) 9219
Atlas_Id 41444
Location 14q32.33  [Link to chromosome band 14q32]
Location_base_pair Starts at 62593203 and ends at 62601840 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CAPNS1 (19q13.12) / MTA2 (11q12.3)EEF1G (11q12.3) / MTA2 (11q12.3)MTA2 (11q12.3) / MS4A18 (11q12.2)
MTA2 (11q12.3) / MTA2 (11q12.3)MTA2 (11q12.3) / PTMA (2q37.1)MTA2 (11q12.3) / SPIDR (8q11.21)
CAPNS1 19q13.12 / MTA2 11q12.3MTA2 11q12.3 / MS4A18 11q12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(11;11)(q12;q12) MTA2/MS4A18
t(11;19)(q12;q13) CAPNS1/MTA2


External links

Nomenclature
HGNC (Hugo)MTA2   7411
Cards
Entrez_Gene (NCBI)MTA2  9219  metastasis associated 1 family member 2
AliasesMTA1L1; PID
GeneCards (Weizmann)MTA2
Ensembl hg19 (Hinxton)ENSG00000149480 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149480 [Gene_View]  ENSG00000149480 [Sequence]  chr11:62593203-62601840 [Contig_View]  MTA2 [Vega]
ICGC DataPortalENSG00000149480
TCGA cBioPortalMTA2
AceView (NCBI)MTA2
Genatlas (Paris)MTA2
WikiGenes9219
SOURCE (Princeton)MTA2
Genetics Home Reference (NIH)MTA2
Genomic and cartography
GoldenPath hg38 (UCSC)MTA2  -     chr11:62593203-62601840 -  14q32.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTA2  -     14q32.33   [Description]    (hg19-Feb_2009)
EnsemblMTA2 - 14q32.33 [CytoView hg19]  MTA2 - 14q32.33 [CytoView hg38]
Mapping of homologs : NCBIMTA2 [Mapview hg19]  MTA2 [Mapview hg38]
OMIM603947   
Gene and transcription
Genbank (Entrez)AB016591 AF295807 AI380395 AK301569 AL561056
RefSeq transcript (Entrez)NM_001330292 NM_004739
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTA2
Cluster EST : UnigeneHs.173043 [ NCBI ]
CGAP (NCI)Hs.173043
Alternative Splicing GalleryENSG00000149480
Gene ExpressionMTA2 [ NCBI-GEO ]   MTA2 [ EBI - ARRAY_EXPRESS ]   MTA2 [ SEEK ]   MTA2 [ MEM ]
Gene Expression Viewer (FireBrowse)MTA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9219
GTEX Portal (Tissue expression)MTA2
Human Protein AtlasENSG00000149480-MTA2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO94776   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO94776  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO94776
Splice isoforms : SwissVarO94776
PhosPhoSitePlusO94776
Domaine pattern : Prosite (Expaxy)BAH (PS51038)    ELM2 (PS51156)    SANT (PS51293)   
Domains : Interpro (EBI)BAH_dom    ELM2_dom    Homeobox-like_sf    MTA1_R1    MTA2    SANT/Myb    SANT_dom    Znf_GATA   
Domain families : Pfam (Sanger)BAH (PF01426)    ELM2 (PF01448)    GATA (PF00320)    MTA_R1 (PF17226)   
Domain families : Pfam (NCBI)pfam01426    pfam01448    pfam00320    pfam17226   
Domain families : Smart (EMBL)BAH (SM00439)  ELM2 (SM01189)  SANT (SM00717)  ZnF_GATA (SM00401)  
Conserved Domain (NCBI)MTA2
DMDM Disease mutations9219
Blocks (Seattle)MTA2
SuperfamilyO94776
Human Protein Atlas [tissue]ENSG00000149480-MTA2 [tissue]
Peptide AtlasO94776
HPRD07233
IPIIPI00171798   IPI00976971   
Protein Interaction databases
DIP (DOE-UCLA)O94776
IntAct (EBI)O94776
FunCoupENSG00000149480
BioGRIDMTA2
STRING (EMBL)MTA2
ZODIACMTA2
Ontologies - Pathways
QuickGOO94776
Ontology : AmiGOhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  transcription regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, transcription factor binding  transcription factor activity, transcription factor binding  core promoter sequence-specific DNA binding  RNA polymerase II transcription factor binding  RNA polymerase II repressing transcription factor binding  RNA polymerase II repressing transcription factor binding  transcription coactivator activity  transcription corepressor activity  histone deacetylase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  transcription factor complex  DNA methylation  chromatin assembly or disassembly  zinc ion binding  regulation of fibroblast migration  membrane  histone deacetylation  histone deacetylation  NuRD complex  NuRD complex  nucleosomal DNA binding  protein-containing complex  histone deacetylase binding  histone deacetylase binding  ATP-dependent chromatin remodeling  positive regulation of transcription by RNA polymerase II  
Ontology : EGO-EBIhistone deacetylase complex  negative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  transcription regulatory region sequence-specific DNA binding  RNA polymerase II transcription factor activity, sequence-specific DNA binding  transcription factor activity, transcription factor binding  transcription factor activity, transcription factor binding  core promoter sequence-specific DNA binding  RNA polymerase II transcription factor binding  RNA polymerase II repressing transcription factor binding  RNA polymerase II repressing transcription factor binding  transcription coactivator activity  transcription corepressor activity  histone deacetylase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  nucleoplasm  transcription factor complex  DNA methylation  chromatin assembly or disassembly  zinc ion binding  regulation of fibroblast migration  membrane  histone deacetylation  histone deacetylation  NuRD complex  NuRD complex  nucleosomal DNA binding  protein-containing complex  histone deacetylase binding  histone deacetylase binding  ATP-dependent chromatin remodeling  positive regulation of transcription by RNA polymerase II  
NDEx NetworkMTA2
Atlas of Cancer Signalling NetworkMTA2
Wikipedia pathwaysMTA2
Orthology - Evolution
OrthoDB9219
GeneTree (enSembl)ENSG00000149480
Phylogenetic Trees/Animal Genes : TreeFamMTA2
HOVERGENO94776
HOGENOMO94776
Homologs : HomoloGeneMTA2
Homology/Alignments : Family Browser (UCSC)MTA2
Gene fusions - Rearrangements
Fusion : MitelmanCAPNS1/MTA2 [19q13.12/11q12.3]  [t(11;19)(q12;q13)]  
Fusion : MitelmanMTA2/MS4A18 [11q12.3/11q12.2]  [t(11;11)(q12;q12)]  
Fusion PortalCAPNS1 19q13.12 MTA2 11q12.3 PRAD
Fusion PortalMTA2 11q12.3 MS4A18 11q12.2 LGG
Fusion : QuiverMTA2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTA2
dbVarMTA2
ClinVarMTA2
1000_GenomesMTA2 
Exome Variant ServerMTA2
ExAC (Exome Aggregation Consortium)ENSG00000149480
GNOMAD BrowserENSG00000149480
Varsome BrowserMTA2
Genetic variants : HAPMAP9219
Genomic Variants (DGV)MTA2 [DGVbeta]
DECIPHERMTA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTA2 
Mutations
ICGC Data PortalMTA2 
TCGA Data PortalMTA2 
Broad Tumor PortalMTA2
OASIS PortalMTA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MTA2
DgiDB (Drug Gene Interaction Database)MTA2
DoCM (Curated mutations)MTA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTA2 (select a term)
intoGenMTA2
Cancer3DMTA2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603947   
Orphanet
DisGeNETMTA2
MedgenMTA2
Genetic Testing Registry MTA2
NextProtO94776 [Medical]
TSGene9219
GENETestsMTA2
Target ValidationMTA2
Huge Navigator MTA2 [HugePedia]
snp3D : Map Gene to Disease9219
BioCentury BCIQMTA2
ClinGenMTA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9219
Chemical/Pharm GKB GenePA31219
Clinical trialMTA2
Miscellaneous
canSAR (ICR)MTA2 (select the gene name)
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTA2
EVEXMTA2
GoPubMedMTA2
iHOPMTA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 15:05:25 CEST 2018

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