MTARC2 (mitochondrial amidoxime reducing component 2)

2014-11-01  

Identity

HGNC
MTARC2
LOCATION
1q41
LOCUSID
54996
ALIAS
MARC2,MOSC2

Other Information

Locus ID:

NCBI: 54996
MIM: 614127
HGNC: 26064
Ensembl: ENSG00000117791

Variants:

dbSNP: 54996
ClinVar: 54996
TCGA: ENSG00000117791
COSMIC: MTARC2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117791ENST00000359316Q969Z3
ENSG00000117791ENST00000366913Q969Z3
ENSG00000117791ENST00000425560X1WI34
ENSG00000117791ENST00000469583F6V6Z1

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase 1 - Functionalization of compoundsREACTOMER-HSA-211945

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
245007102014Nitrite reductase and nitric-oxide synthase activity of the mitochondrial molybdopterin enzymes mARC1 and mARC2.40
208610212010Biochemical and spectroscopic characterization of the human mitochondrial amidoxime reducing components hmARC-1 and hmARC-2 suggests the existence of a new molybdenum enzyme family in eukaryotes.30
210290452011Reduction of N(ω)-hydroxy-L-arginine by the mitochondrial amidoxime reducing component (mARC).21
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
208088252010Novel association strategy with copy number variation for identifying new risk Loci of human diseases.11
218038662011The Chlamydomonas reinhardtii molybdenum cofactor enzyme crARC has a Zn-dependent activity and protein partners similar to those of its human homologue.8
257130762015The pivotal role of the mitochondrial amidoxime reducing component 2 in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine.6
219164122011Structural studies of the molybdenum center of mitochondrial amidoxime reducing component (mARC) by pulsed EPR spectroscopy and 17O-labeling.5
237036162013The involvement of mitochondrial amidoxime reducing components 1 and 2 and mitochondrial cytochrome b5 in N-reductive metabolism in human cells.5

Citation

Dessen P

MTARC2 (mitochondrial amidoxime reducing component 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68805/mtarc2