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MTCL1 (microtubule crosslinking factor 1)

Identity

Alias_namesKIAA0802
CCDC165
SOGA2
KIAA0802
coiled-coil domain containing 165
SOGA family member 2
Other alias
HGNC (Hugo) MTCL1
LocusID (NCBI) 23255
Atlas_Id 54475
Location 18p11.22  [Link to chromosome band 18p11]
Location_base_pair Starts at 8717369 and ends at 8832775 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MTCL1 (18p11.22) / CCT8 (21q21.3)MTCL1 (18p11.22) / DLGAP1 (18p11.31)MTCL1 (18p11.22) / LRRC41 (1p34.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTCL1   29121
Cards
Entrez_Gene (NCBI)MTCL1  23255  microtubule crosslinking factor 1
AliasesCCDC165; KIAA0802; SOGA2
GeneCards (Weizmann)MTCL1
Ensembl hg19 (Hinxton)ENSG00000168502 [Gene_View]  chr18:8717369-8832775 [Contig_View]  MTCL1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168502 [Gene_View]  chr18:8717369-8832775 [Contig_View]  MTCL1 [Vega]
ICGC DataPortalENSG00000168502
TCGA cBioPortalMTCL1
AceView (NCBI)MTCL1
Genatlas (Paris)MTCL1
WikiGenes23255
SOURCE (Princeton)MTCL1
Genetics Home Reference (NIH)MTCL1
Genomic and cartography
GoldenPath hg19 (UCSC)MTCL1  -     chr18:8717369-8832775 +  18p11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MTCL1  -     18p11.22   [Description]    (hg38-Dec_2013)
EnsemblMTCL1 - 18p11.22 [CytoView hg19]  MTCL1 - 18p11.22 [CytoView hg38]
Mapping of homologs : NCBIMTCL1 [Mapview hg19]  MTCL1 [Mapview hg38]
OMIM615766   
Gene and transcription
Genbank (Entrez)AB018345 AK131528 AK307830 BC040542 BX648455
RefSeq transcript (Entrez)NM_015210
RefSeq genomic (Entrez)NC_000018 NC_018929 NT_010859 NW_004929409
Consensus coding sequences : CCDS (NCBI)MTCL1
Cluster EST : UnigeneHs.707920 [ NCBI ]
CGAP (NCI)Hs.707920
Alternative Splicing GalleryENSG00000168502
Gene ExpressionMTCL1 [ NCBI-GEO ]   MTCL1 [ EBI - ARRAY_EXPRESS ]   MTCL1 [ SEEK ]   MTCL1 [ MEM ]
Gene Expression Viewer (FireBrowse)MTCL1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23255
GTEX Portal (Tissue expression)MTCL1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y4B5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y4B5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y4B5
Splice isoforms : SwissVarQ9Y4B5
PhosPhoSitePlusQ9Y4B5
Domains : Interpro (EBI)DUF4482    SOGA   
Domain families : Pfam (Sanger)DUF3166 (PF11365)    DUF4482 (PF14818)   
Domain families : Pfam (NCBI)pfam11365    pfam14818   
Conserved Domain (NCBI)MTCL1
DMDM Disease mutations23255
Blocks (Seattle)MTCL1
SuperfamilyQ9Y4B5
Human Protein AtlasENSG00000168502
Peptide AtlasQ9Y4B5
HPRD11110
IPIIPI00792611   IPI00829780   IPI00477620   IPI00375286   IPI00794856   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y4B5
IntAct (EBI)Q9Y4B5
FunCoupENSG00000168502
BioGRIDMTCL1
STRING (EMBL)MTCL1
ZODIACMTCL1
Ontologies - Pathways
QuickGOQ9Y4B5
Ontology : AmiGOspindle pole  microtubule bundle formation  microtubule bundle formation  protein binding  extracellular space  cytoplasm  cytoskeleton  microtubule binding  regulation of autophagy  apical plasma membrane  apicolateral plasma membrane  apicolateral plasma membrane  lateral plasma membrane  lateral plasma membrane  midbody  protein homodimerization activity  poly(A) RNA binding  establishment or maintenance of epithelial cell apical/basal polarity  establishment or maintenance of epithelial cell apical/basal polarity  positive regulation of protein targeting to membrane  microtubule bundle  microtubule bundle  positive regulation of microtubule motor activity  
Ontology : EGO-EBIspindle pole  microtubule bundle formation  microtubule bundle formation  protein binding  extracellular space  cytoplasm  cytoskeleton  microtubule binding  regulation of autophagy  apical plasma membrane  apicolateral plasma membrane  apicolateral plasma membrane  lateral plasma membrane  lateral plasma membrane  midbody  protein homodimerization activity  poly(A) RNA binding  establishment or maintenance of epithelial cell apical/basal polarity  establishment or maintenance of epithelial cell apical/basal polarity  positive regulation of protein targeting to membrane  microtubule bundle  microtubule bundle  positive regulation of microtubule motor activity  
NDEx NetworkMTCL1
Atlas of Cancer Signalling NetworkMTCL1
Wikipedia pathwaysMTCL1
Orthology - Evolution
OrthoDB23255
GeneTree (enSembl)ENSG00000168502
Phylogenetic Trees/Animal Genes : TreeFamMTCL1
HOVERGENQ9Y4B5
HOGENOMQ9Y4B5
Homologs : HomoloGeneMTCL1
Homology/Alignments : Family Browser (UCSC)MTCL1
Gene fusions - Rearrangements
Fusion : MitelmanMTCL1/CCT8 [18p11.22/21q21.3]  
Fusion : MitelmanMTCL1/DLGAP1 [18p11.22/18p11.31]  [t(18;18)(p11;p11)]  
Fusion : MitelmanMTCL1/LRRC41 [18p11.22/1p34.1]  [t(1;18)(p34;p11)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTCL1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTCL1
dbVarMTCL1
ClinVarMTCL1
1000_GenomesMTCL1 
Exome Variant ServerMTCL1
ExAC (Exome Aggregation Consortium)MTCL1 (select the gene name)
Genetic variants : HAPMAP23255
Genomic Variants (DGV)MTCL1 [DGVbeta]
DECIPHER (Syndromes)18:8717369-8832775  ENSG00000168502
CONAN: Copy Number AnalysisMTCL1 
Mutations
ICGC Data PortalMTCL1 
TCGA Data PortalMTCL1 
Broad Tumor PortalMTCL1
OASIS PortalMTCL1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMTCL1
BioMutasearch MTCL1
DgiDB (Drug Gene Interaction Database)MTCL1
DoCM (Curated mutations)MTCL1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTCL1 (select a term)
intoGenMTCL1
Cancer3DMTCL1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM615766   
Orphanet
MedgenMTCL1
Genetic Testing Registry MTCL1
NextProtQ9Y4B5 [Medical]
TSGene23255
GENETestsMTCL1
Huge Navigator MTCL1 [HugePedia]
snp3D : Map Gene to Disease23255
BioCentury BCIQMTCL1
ClinGenMTCL1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23255
Chemical/Pharm GKB GenePA128394616
Clinical trialMTCL1
Miscellaneous
canSAR (ICR)MTCL1 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTCL1
EVEXMTCL1
GoPubMedMTCL1
iHOPMTCL1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:11:12 CEST 2017

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