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MTCP1 (Mature T Cell Proliferation 1)

Written1998-03Marc-Henri Stern
Unité INSERM U462, Centre Hayem, Hopital Saint Louis, 75475 Paris Cedex 10, France

(Note : for Links provided by Atlas : click)


Alias (NCBI)C6.1B
HGNC Alias symbP13MTCP1
HGNC Previous namemature T-cell proliferation 1
LocusID (NCBI) 4515
Atlas_Id 89
Location Xq28  [Link to chromosome band Xq28]
Location_base_pair Starts at 155064034 and ends at 155071136 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping MTCP1.png]
Local_order centromere- Factor VIII - c6.1A - MTCP1 - telomere
  MTCP1 (Xq28) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GID4 (17p11.2) / MTCP1 (Xq28)MTCP1 (Xq28) / MST1L (1p36.13)


  DNA Diagram
Description 7 exons; about 10 kb
Transcription complex; alternative splicing: two donor sites in exon 1; transcripts A, the most abondant, ubiquitous: splicing from exon 1 to exon 6; transcripts B, rare: splicing from exon 1 to exon 2; initiation of the transcription: an alternative site of initiation of the transcription in intron 1 has been found in one tumor with a translocation breakpoint in intron 1


Description p13 MTCP1: coded by transcripts B, 107 amino acides; one domain with a b-barrel topology
Expression protein expression undetectable in physiological conditions
Localisation cytosol
Function unknown
Homology TCL1 (39% identity, similar tridimentional structure)

Implicated in

Entity t(X;14)(q28;q12) / prolymphocytic leukaemia --> TCRA/TRA - MTCP1
Disease T-cell prolymphocytic leukaemia
Cytogenetics associated with i(8q)
Hybrid/Mutated Gene unconstant TCRA-c6.1A transcripts have been described
Abnormal Protein none
Oncogenesis over expression of p13 MTCP1 is considered as critical in the oncogenetic mechanism
Entity t(X;7)(q28;q35) / prolymphocytic leukaemia --> TCRB - MTCP1
Disease T-cell prolymphocytic leukemia
Oncogenesis over expression of p13 MTCP1


Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif.
Barthe P, Yang YS, Chiche L, Hoh F, Strub MP, Guignard L, Soulier J, Stern MH, van Tilbeurgh H, Lhoste JM, Roumestand C
Journal of molecular biology. 1997 ; 274 (5) : 801-815.
PMID 9405159
The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another.
Fisch P, Forster A, Sherrington PD, Dyer MJ, Rabbitts TH
Oncogene. 1993 ; 8 (12) : 3271-3276.
PMID 8247530
Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations.
Gritti C, Choukroun V, Soulier J, Madani A, Dastot H, Leblond V, Radford-Weiss I, Valensi F, Varet B, Sigaux F, Stern MH
Oncogene. 1997 ; 15 (11) : 1329-1335.
PMID 9315101
Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations.
Madani A, Choukroun V, Soulier J, Cacheux V, Claisse JF, Valensi F, Daliphard S, Cazin B, Levy V, Leblond V, Daniel MT, Sigaux F, Stern MH
Blood. 1996 ; 87 (5) : 1923-1927.
PMID 8634440
The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation.
Soulier J, Madani A, Cacheux V, Rosenzwajg M, Sigaux F, Stern MH
Oncogene. 1994 ; 9 (12) : 3565-3570.
PMID 7970717
A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia.
Thick J, Mak YF, Metcalfe J, Beatty D, Taylor AM
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 1994 ; 8 (4) : 564-573.
PMID 8152252
Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.
Thick J, Metcalfe JA, Mak YF, Beatty D, Minegishi M, Dyer MJ, Lucas G, Taylor AM
Oncogene. 1996 ; 12 (2) : 379-386.
PMID 8570215
Solution structure of the recombinant human oncoprotein p13MTCP1.
Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C
Journal of biomolecular NMR. 1998 ; 11 (3) : 337-354.
PMID 9691281


This paper should be referenced as such :
Stern, MH
MTCP1 (mature T cell proliferation 1)
Atlas Genet Cytogenet Oncol Haematol. 1998;2(2):37-38.
Free journal version : [ pdf ]   [ DOI ]

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 6 ]
  t(7;14)(q35;q32.1) TRB/TCL1A::inv(14)(q11q32.1) TRA-TRD/TCL1A::t(14;14)(q11;q32.1) TRA-TRD/TCL1A
T-lineage acute lymphoblastic leukemia (T-ALL)
Classification of T-Cell disorders
t(X;14)(q28;q11) TRA/MTCP1
T-cell prolymphocytic leukemia (T-PLL)
t(X;14)(q28;q11.2) TRA-TRD/MTCP1::t(X;7)(q28;q34) TRB/MTCP1

External links

HGNC (Hugo)MTCP1   7423
Entrez_Gene (NCBI)MTCP1    mature T cell proliferation 1
AliasesP13MTCP1; TCL1C; p8MTCP1
GeneCards (Weizmann)MTCP1
Ensembl hg19 (Hinxton)ENSG00000214827 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000214827 [Gene_View]  ENSG00000214827 [Sequence]  chrX:155064034-155071136 [Contig_View]  MTCP1 [Vega]
ICGC DataPortalENSG00000214827
TCGA cBioPortalMTCP1
Genatlas (Paris)MTCP1
SOURCE (Princeton)MTCP1
Genetics Home Reference (NIH)MTCP1
Genomic and cartography
GoldenPath hg38 (UCSC)MTCP1  -     chrX:155064034-155071136 -  Xq28   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTCP1  -     Xq28   [Description]    (hg19-Feb_2009)
GoldenPathMTCP1 - Xq28 [CytoView hg19]  MTCP1 - Xq28 [CytoView hg38]
genome Data Viewer NCBIMTCP1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AA744518 AW976554
RefSeq transcript (Entrez)NM_001018025 NM_014221
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTCP1
Alternative Splicing GalleryENSG00000214827
Gene ExpressionMTCP1 [ NCBI-GEO ]   MTCP1 [ EBI - ARRAY_EXPRESS ]   MTCP1 [ SEEK ]   MTCP1 [ MEM ]
Gene Expression Viewer (FireBrowse)MTCP1 [ Firebrowse - Broad ]
GenevisibleExpression of MTCP1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4515
GTEX Portal (Tissue expression)MTCP1
Human Protein AtlasENSG00000214827-MTCP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP56278   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP56278  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP56278
Splice isoforms : SwissVarP56278
Domains : Interpro (EBI)TCL1_MTCP1    TCL1_MTCP1_sf   
Domain families : Pfam (Sanger)TCL1_MTCP1 (PF01840)   
Domain families : Pfam (NCBI)pfam01840   
Conserved Domain (NCBI)MTCP1
Blocks (Seattle)MTCP1
PDB (RSDB)1A1X    1QTT    1QTU   
PDB Europe1A1X    1QTT    1QTU   
PDB (PDBSum)1A1X    1QTT    1QTU   
PDB (IMB)1A1X    1QTT    1QTU   
Structural Biology KnowledgeBase1A1X    1QTT    1QTU   
SCOP (Structural Classification of Proteins)1A1X    1QTT    1QTU   
CATH (Classification of proteins structures)1A1X    1QTT    1QTU   
Human Protein Atlas [tissue]ENSG00000214827-MTCP1 [tissue]
Peptide AtlasP56278
IPIIPI00447137   IPI00964570   
Protein Interaction databases
IntAct (EBI)P56278
Ontologies - Pathways
Ontology : AmiGOprotein kinase binding  protein-containing complex  positive regulation of peptidyl-serine phosphorylation  positive regulation of peptidyl-serine phosphorylation  protein serine/threonine kinase activator activity  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  
Ontology : EGO-EBIprotein kinase binding  protein-containing complex  positive regulation of peptidyl-serine phosphorylation  positive regulation of peptidyl-serine phosphorylation  protein serine/threonine kinase activator activity  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  
Pathways : KEGGPI3K-Akt signaling pathway   
NDEx NetworkMTCP1
Atlas of Cancer Signalling NetworkMTCP1
Wikipedia pathwaysMTCP1
Orthology - Evolution
GeneTree (enSembl)ENSG00000214827
Phylogenetic Trees/Animal Genes : TreeFamMTCP1
Homologs : HomoloGeneMTCP1
Homology/Alignments : Family Browser (UCSC)MTCP1
Gene fusions - Rearrangements
Fusion : MitelmanTRA/MTCP1 [-/Xq28]  
Fusion : Fusion_HubCMC4--MTCP1    MTCP1--NEDD1    MTCP1--TRA@    MTCP1--TRB@    TCL1--MTCP1   
Fusion : QuiverMTCP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTCP1 [hg38]
Exome Variant ServerMTCP1
GNOMAD BrowserENSG00000214827
Varsome BrowserMTCP1
Genomic Variants (DGV)MTCP1 [DGVbeta]
DECIPHERMTCP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTCP1 
ICGC Data PortalMTCP1 
TCGA Data PortalMTCP1 
Broad Tumor PortalMTCP1
OASIS PortalMTCP1 [ Somatic mutations - Copy number]
Cancer Gene: CensusMTCP1 
Somatic Mutations in Cancer : COSMICMTCP1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMTCP1
Mutations and Diseases : HGMDMTCP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MTCP1
DgiDB (Drug Gene Interaction Database)MTCP1
DoCM (Curated mutations)MTCP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTCP1 (select a term)
NCG6 (London) select MTCP1
Cancer3DMTCP1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry MTCP1
NextProtP56278 [Medical]
Target ValidationMTCP1
Huge Navigator MTCP1 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTD
Pharm GKB GenePA164742098
Clinical trialMTCP1
canSAR (ICR)MTCP1 (select the gene name)
DataMed IndexMTCP1
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 25 20:05:09 CET 2021

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