Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MTDH (metadherin)

Identity

Alias_symbol (synonym)LYRIC
3D3
AEG-1
Other aliasAEG1
LYRIC/3D3
HGNC (Hugo) MTDH
LocusID (NCBI) 92140
Atlas_Id 43863
Location 8q22.1  [Link to chromosome band 8q22]
Location_base_pair Starts at 97644179 and ends at 97730260 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BOLA2 (16p11.2) / MTDH (8q22.1)EXOC7 (17q25.1) / MTDH (8q22.1)MTDH (8q22.1) / CUL5 (11q22.3)
MTDH (8q22.1) / FAM167A-AS1 (8p23.1)MTDH (8q22.1) / HMGB2 (4q34.1)MTDH (8q22.1) / MTDH (8q22.1)
MTDH (8q22.1) / SNX31 (8q22.2)MTDH (8q22.1) / SPIDR (8q11.21)MTDH (8q22.1) / TRHR (8q23.1)
MTDH 8q22.1 KIAA0146MTDH 8q22.1 / SNX31 8q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Male breast cancer


External links

Nomenclature
HGNC (Hugo)MTDH   29608
Cards
Entrez_Gene (NCBI)MTDH  92140  metadherin
Aliases3D3; AEG-1; AEG1; LYRIC; 
LYRIC/3D3
GeneCards (Weizmann)MTDH
Ensembl hg19 (Hinxton)ENSG00000147649 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147649 [Gene_View]  chr8:97644179-97730260 [Contig_View]  MTDH [Vega]
ICGC DataPortalENSG00000147649
TCGA cBioPortalMTDH
AceView (NCBI)MTDH
Genatlas (Paris)MTDH
WikiGenes92140
SOURCE (Princeton)MTDH
Genetics Home Reference (NIH)MTDH
Genomic and cartography
GoldenPath hg38 (UCSC)MTDH  -     chr8:97644179-97730260 +  8q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTDH  -     8q22.1   [Description]    (hg19-Feb_2009)
EnsemblMTDH - 8q22.1 [CytoView hg19]  MTDH - 8q22.1 [CytoView hg38]
Mapping of homologs : NCBIMTDH [Mapview hg19]  MTDH [Mapview hg38]
OMIM610323   
Gene and transcription
Genbank (Entrez)AF411226 AF501310 AK000745 AK123083 AK308030
RefSeq transcript (Entrez)NM_178812
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTDH
Cluster EST : UnigeneHs.377155 [ NCBI ]
CGAP (NCI)Hs.377155
Alternative Splicing GalleryENSG00000147649
Gene ExpressionMTDH [ NCBI-GEO ]   MTDH [ EBI - ARRAY_EXPRESS ]   MTDH [ SEEK ]   MTDH [ MEM ]
Gene Expression Viewer (FireBrowse)MTDH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92140
GTEX Portal (Tissue expression)MTDH
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UE4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UE4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UE4
Splice isoforms : SwissVarQ86UE4
PhosPhoSitePlusQ86UE4
Domains : Interpro (EBI)LYRIC   
Domain families : Pfam (Sanger)LYRIC (PF15686)   
Domain families : Pfam (NCBI)pfam15686   
Conserved Domain (NCBI)MTDH
DMDM Disease mutations92140
Blocks (Seattle)MTDH
PDB (SRS)4QMG   
PDB (PDBSum)4QMG   
PDB (IMB)4QMG   
PDB (RSDB)4QMG   
Structural Biology KnowledgeBase4QMG   
SCOP (Structural Classification of Proteins)4QMG   
CATH (Classification of proteins structures)4QMG   
SuperfamilyQ86UE4
Human Protein AtlasENSG00000147649
Peptide AtlasQ86UE4
HPRD17459
IPIIPI00328715   IPI00973911   IPI00983638   IPI00976550   IPI00977203   
Protein Interaction databases
DIP (DOE-UCLA)Q86UE4
IntAct (EBI)Q86UE4
FunCoupENSG00000147649
BioGRIDMTDH
STRING (EMBL)MTDH
ZODIACMTDH
Ontologies - Pathways
QuickGOQ86UE4
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor binding  fibrillar center  transcription coactivator activity  RNA binding  double-stranded RNA binding  protein binding  nucleus  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  bicellular tight junction  positive regulation of autophagy  integral component of membrane  apical plasma membrane  nuclear body  lipopolysaccharide-mediated signaling pathway  nuclear membrane  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of angiogenesis  intercellular canaliculus  perinuclear region of cytoplasm  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  bicellular tight junction assembly  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II transcription factor binding  fibrillar center  transcription coactivator activity  RNA binding  double-stranded RNA binding  protein binding  nucleus  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  bicellular tight junction  positive regulation of autophagy  integral component of membrane  apical plasma membrane  nuclear body  lipopolysaccharide-mediated signaling pathway  nuclear membrane  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of angiogenesis  intercellular canaliculus  perinuclear region of cytoplasm  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  bicellular tight junction assembly  
NDEx NetworkMTDH
Atlas of Cancer Signalling NetworkMTDH
Wikipedia pathwaysMTDH
Orthology - Evolution
OrthoDB92140
GeneTree (enSembl)ENSG00000147649
Phylogenetic Trees/Animal Genes : TreeFamMTDH
HOVERGENQ86UE4
HOGENOMQ86UE4
Homologs : HomoloGeneMTDH
Homology/Alignments : Family Browser (UCSC)MTDH
Gene fusions - Rearrangements
Fusion : MitelmanMTDH/SNX31 [8q22.1/8q22.2]  
Fusion : MitelmanMTDH/SPIDR [8q22.1/8q11.21]  [t(8;8)(q11;q22)]  
Fusion: TCGAMTDH 8q22.1 KIAA0146 BRCA
Fusion: TCGAMTDH 8q22.1 SNX31 8q22.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTDH
dbVarMTDH
ClinVarMTDH
1000_GenomesMTDH 
Exome Variant ServerMTDH
ExAC (Exome Aggregation Consortium)MTDH (select the gene name)
Genetic variants : HAPMAP92140
Genomic Variants (DGV)MTDH [DGVbeta]
DECIPHERMTDH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTDH 
Mutations
ICGC Data PortalMTDH 
TCGA Data PortalMTDH 
Broad Tumor PortalMTDH
OASIS PortalMTDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTDH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTDH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MTDH
DgiDB (Drug Gene Interaction Database)MTDH
DoCM (Curated mutations)MTDH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTDH (select a term)
intoGenMTDH
Cancer3DMTDH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610323   
Orphanet
MedgenMTDH
Genetic Testing Registry MTDH
NextProtQ86UE4 [Medical]
TSGene92140
GENETestsMTDH
Target ValidationMTDH
Huge Navigator MTDH [HugePedia]
snp3D : Map Gene to Disease92140
BioCentury BCIQMTDH
ClinGenMTDH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD92140
Chemical/Pharm GKB GenePA142671307
Clinical trialMTDH
Miscellaneous
canSAR (ICR)MTDH (select the gene name)
Probes
Litterature
PubMed206 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTDH
EVEXMTDH
GoPubMedMTDH
iHOPMTDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 17:08:19 CEST 2017

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