Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MTDH (metadherin)

Identity

Alias (NCBI)3D3
AEG-1
AEG1
LYRIC
LYRIC/3D3
HGNC (Hugo) MTDH
HGNC Alias symbLYRIC
3D3
AEG-1
HGNC Alias nameastrocyte elevated gene 1
LocusID (NCBI) 92140
Atlas_Id 43863
Location 8q22.1  [Link to chromosome band 8q22]
Location_base_pair Starts at 97644184 and ends at 97730260 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BOLA2 (16p11.2) / MTDH (8q22.1)EXOC7 (17q25.1) / MTDH (8q22.1)MTDH (8q22.1) / CUL5 (11q22.3)
MTDH (8q22.1) / FAM167A-AS1 (8p23.1)MTDH (8q22.1) / HMGB2 (4q34.1)MTDH (8q22.1) / MTDH (8q22.1)
MTDH (8q22.1) / SNX31 (8q22.2)MTDH (8q22.1) / SPIDR (8q11.21)MTDH (8q22.1) / TRHR (8q23.1)
MTDH 8q22.1 KIAA0146MTDH 8q22.1 / SNX31 8q22.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MTDH   29608
Cards
Entrez_Gene (NCBI)MTDH    metadherin
Aliases3D3; AEG-1; AEG1; LYRIC; 
LYRIC/3D3
GeneCards (Weizmann)MTDH
Ensembl hg19 (Hinxton)ENSG00000147649 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000147649 [Gene_View]  ENSG00000147649 [Sequence]  chr8:97644184-97730260 [Contig_View]  MTDH [Vega]
ICGC DataPortalENSG00000147649
TCGA cBioPortalMTDH
AceView (NCBI)MTDH
Genatlas (Paris)MTDH
SOURCE (Princeton)MTDH
Genetics Home Reference (NIH)MTDH
Genomic and cartography
GoldenPath hg38 (UCSC)MTDH  -     chr8:97644184-97730260 +  8q22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTDH  -     8q22.1   [Description]    (hg19-Feb_2009)
GoldenPathMTDH - 8q22.1 [CytoView hg19]  MTDH - 8q22.1 [CytoView hg38]
ImmunoBaseENSG00000147649
Genome Data Viewer NCBIMTDH [Mapview hg19]  
OMIM610323   
Gene and transcription
Genbank (Entrez)AF411226 AF501310 AK000745 AK123083 AK308030
RefSeq transcript (Entrez)NM_001363136 NM_001363137 NM_001363138 NM_001363139 NM_178812
Consensus coding sequences : CCDS (NCBI)MTDH
Gene ExpressionMTDH [ NCBI-GEO ]   MTDH [ EBI - ARRAY_EXPRESS ]   MTDH [ SEEK ]   MTDH [ MEM ]
Gene Expression Viewer (FireBrowse)MTDH [ Firebrowse - Broad ]
GenevisibleExpression of MTDH in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)92140
GTEX Portal (Tissue expression)MTDH
Human Protein AtlasENSG00000147649-MTDH [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UE4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UE4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UE4
PhosPhoSitePlusQ86UE4
Domains : Interpro (EBI)LYRIC   
Domain families : Pfam (Sanger)LYRIC (PF15686)   
Domain families : Pfam (NCBI)pfam15686   
Conserved Domain (NCBI)MTDH
PDB (RSDB)4QMG   
PDB Europe4QMG   
PDB (PDBSum)4QMG   
PDB (IMB)4QMG   
Structural Biology KnowledgeBase4QMG   
SCOP (Structural Classification of Proteins)4QMG   
CATH (Classification of proteins structures)4QMG   
SuperfamilyQ86UE4
AlphaFold pdb e-kbQ86UE4   
Human Protein Atlas [tissue]ENSG00000147649-MTDH [tissue]
HPRD17459
Protein Interaction databases
DIP (DOE-UCLA)Q86UE4
IntAct (EBI)Q86UE4
BioGRIDMTDH
STRING (EMBL)MTDH
ZODIACMTDH
Ontologies - Pathways
QuickGOQ86UE4
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  fibrillar center  transcription coregulator activity  transcription coactivator activity  RNA binding  double-stranded RNA binding  protein binding  nucleus  nucleus  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  bicellular tight junction  regulation of transcription by RNA polymerase II  positive regulation of autophagy  integral component of membrane  apical plasma membrane  nuclear body  lipopolysaccharide-mediated signaling pathway  nuclear membrane  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of angiogenesis  positive regulation of transcription, DNA-templated  intercellular canaliculus  perinuclear region of cytoplasm  NF-kappaB binding  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  RNA polymerase II-specific DNA-binding transcription factor binding  bicellular tight junction assembly  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  fibrillar center  transcription coregulator activity  transcription coactivator activity  RNA binding  double-stranded RNA binding  protein binding  nucleus  nucleus  cytoplasm  endoplasmic reticulum  endoplasmic reticulum membrane  bicellular tight junction  regulation of transcription by RNA polymerase II  positive regulation of autophagy  integral component of membrane  apical plasma membrane  nuclear body  lipopolysaccharide-mediated signaling pathway  nuclear membrane  negative regulation of apoptotic process  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of angiogenesis  positive regulation of transcription, DNA-templated  intercellular canaliculus  perinuclear region of cytoplasm  NF-kappaB binding  NF-kappaB binding  positive regulation of NF-kappaB transcription factor activity  positive regulation of protein kinase B signaling  RNA polymerase II-specific DNA-binding transcription factor binding  bicellular tight junction assembly  
NDEx NetworkMTDH
Atlas of Cancer Signalling NetworkMTDH
Wikipedia pathwaysMTDH
Orthology - Evolution
OrthoDB92140
GeneTree (enSembl)ENSG00000147649
Phylogenetic Trees/Animal Genes : TreeFamMTDH
Homologs : HomoloGeneMTDH
Homology/Alignments : Family Browser (UCSC)MTDH
Gene fusions - Rearrangements
Fusion : MitelmanMTDH/SNX31 [8q22.1/8q22.2]  
Fusion : MitelmanMTDH/SPIDR [8q22.1/8q11.21]  
Fusion : QuiverMTDH
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTDH
dbVarMTDH
ClinVarMTDH
MonarchMTDH
1000_GenomesMTDH 
Exome Variant ServerMTDH
GNOMAD BrowserENSG00000147649
Varsome BrowserMTDH
ACMGMTDH variants
VarityQ86UE4
Genomic Variants (DGV)MTDH [DGVbeta]
DECIPHERMTDH [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTDH 
Mutations
ICGC Data PortalMTDH 
TCGA Data PortalMTDH 
Broad Tumor PortalMTDH
OASIS PortalMTDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTDH  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMTDH
Mutations and Diseases : HGMDMTDH
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMTDH
DgiDB (Drug Gene Interaction Database)MTDH
DoCM (Curated mutations)MTDH
CIViC (Clinical Interpretations of Variants in Cancer)MTDH
Cancer3DMTDH
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610323   
Orphanet
DisGeNETMTDH
MedgenMTDH
Genetic Testing Registry MTDH
NextProtQ86UE4 [Medical]
GENETestsMTDH
Target ValidationMTDH
Huge Navigator MTDH [HugePedia]
ClinGenMTDH
Clinical trials, drugs, therapy
MyCancerGenomeMTDH
Protein Interactions : CTDMTDH
Pharm GKB GenePA142671307
PharosQ86UE4
Clinical trialMTDH
Miscellaneous
canSAR (ICR)MTDH
HarmonizomeMTDH
DataMed IndexMTDH
Probes
Litterature
PubMed351 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMTDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:21:30 CEST 2021

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