MTDH (metadherin)

2007-02-01  

Identity

HGNC
LOCATION
8q22.1
LOCUSID
ALIAS
3D3,AEG-1,AEG1,LYRIC,LYRIC/3D3
FUSION GENES

Other Information

Locus ID:

NCBI: 92140
MIM: 610323
HGNC: 29608
Ensembl: ENSG00000147649

Variants:

dbSNP: 92140
ClinVar: 92140
TCGA: ENSG00000147649
COSMIC: MTDH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000147649ENST00000336273Q86UE4
ENSG00000147649ENST00000336273A0A024R9D2
ENSG00000147649ENST00000519293H0YBE0
ENSG00000147649ENST00000519934E5RJU9
ENSG00000147649ENST00000521933H0YBJ8
ENSG00000147649ENST00000522313H0YB56

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191118772009MTDH activation by 8q22 genomic gain promotes chemoresistance and metastasis of poor-prognosis breast cancer.171
192214382009Astrocyte elevated gene-1 regulates hepatocellular carcinoma development and progression.131
185197592008Astrocyte elevated gene-1 is a novel prognostic marker for breast cancer progression and overall patient survival.129
150935432004Metadherin, a cell surface protein in breast tumors that mediates lung metastasis.124
220568812012MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo.121
183166122008Molecular basis of nuclear factor-kappaB activation by astrocyte elevated gene-1.103
208024792010Genome-wide association study of migraine implicates a common susceptibility variant on 8q22.1.100
177048082008Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling.92
209525132011Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer.89
175637452007Knockdown of astrocyte-elevated gene-1 inhibits prostate cancer progression through upregulation of FOXO3a activity.88

Citation

Dessen P

MTDH (metadherin)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43863/mtdh