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MTF1 (metal regulatory transcription factor 1)

Identity

Other aliasMTF-1
ZRF
HGNC (Hugo) MTF1
LocusID (NCBI) 4520
Atlas_Id 51363
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 37809567 and ends at 37859620 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ASB3 (2p16.2) / MTF1 (1p34.3)MTF1 (1p34.3) / MTF1 (1p34.3)MTF1 (1p34.3) / SERINC2 (1p35.2)
MTF1 (1p34.3) / SF3A3 (1p34.3)MTF1 1p34.3 / SERINC2 1p35.2MTF1 1p34.3 / SF3A3 1p34.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MTF1   7428
Cards
Entrez_Gene (NCBI)MTF1  4520  metal regulatory transcription factor 1
AliasesMTF-1; ZRF
GeneCards (Weizmann)MTF1
Ensembl hg19 (Hinxton)ENSG00000188786 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188786 [Gene_View]  chr1:37809567-37859620 [Contig_View]  MTF1 [Vega]
ICGC DataPortalENSG00000188786
TCGA cBioPortalMTF1
AceView (NCBI)MTF1
Genatlas (Paris)MTF1
WikiGenes4520
SOURCE (Princeton)MTF1
Genetics Home Reference (NIH)MTF1
Genomic and cartography
GoldenPath hg38 (UCSC)MTF1  -     chr1:37809567-37859620 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MTF1  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblMTF1 - 1p34.3 [CytoView hg19]  MTF1 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIMTF1 [Mapview hg19]  MTF1 [Mapview hg38]
OMIM600172   
Gene and transcription
Genbank (Entrez)AI915521 AK125603 AK225923 AK298751 AK309584
RefSeq transcript (Entrez)NM_005955
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MTF1
Cluster EST : UnigeneHs.471991 [ NCBI ]
CGAP (NCI)Hs.471991
Alternative Splicing GalleryENSG00000188786
Gene ExpressionMTF1 [ NCBI-GEO ]   MTF1 [ EBI - ARRAY_EXPRESS ]   MTF1 [ SEEK ]   MTF1 [ MEM ]
Gene Expression Viewer (FireBrowse)MTF1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4520
GTEX Portal (Tissue expression)MTF1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14872   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14872  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14872
Splice isoforms : SwissVarQ14872
PhosPhoSitePlusQ14872
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)MTF1
DMDM Disease mutations4520
Blocks (Seattle)MTF1
SuperfamilyQ14872
Human Protein AtlasENSG00000188786
Peptide AtlasQ14872
HPRD02546
IPIIPI00025546   IPI00816030   IPI01014104   
Protein Interaction databases
DIP (DOE-UCLA)Q14872
IntAct (EBI)Q14872
FunCoupENSG00000188786
BioGRIDMTF1
STRING (EMBL)MTF1
ZODIACMTF1
Ontologies - Pathways
QuickGOQ14872
Ontology : AmiGORNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  response to oxidative stress  response to metal ion  histone acetyltransferase binding  positive regulation of transcription from RNA polymerase II promoter  response to cadmium ion  metal ion binding  
Ontology : EGO-EBIRNA polymerase II core promoter proximal region sequence-specific DNA binding  RNA polymerase II core promoter sequence-specific DNA binding  core promoter binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  DNA binding  transcription factor activity, sequence-specific DNA binding  transcription coactivator activity  protein binding  nucleus  nucleoplasm  regulation of transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  response to oxidative stress  response to metal ion  histone acetyltransferase binding  positive regulation of transcription from RNA polymerase II promoter  response to cadmium ion  metal ion binding  
NDEx NetworkMTF1
Atlas of Cancer Signalling NetworkMTF1
Wikipedia pathwaysMTF1
Orthology - Evolution
OrthoDB4520
GeneTree (enSembl)ENSG00000188786
Phylogenetic Trees/Animal Genes : TreeFamMTF1
HOVERGENQ14872
HOGENOMQ14872
Homologs : HomoloGeneMTF1
Homology/Alignments : Family Browser (UCSC)MTF1
Gene fusions - Rearrangements
Fusion : MitelmanMTF1/SERINC2 [1p34.3/1p35.2]  
Fusion : MitelmanMTF1/SF3A3 [1p34.3/1p34.3]  [t(1;1)(p34;p34)]  
Fusion: TCGAMTF1 1p34.3 SERINC2 1p35.2 KIRC
Fusion: TCGAMTF1 1p34.3 SF3A3 1p34.3 BRCA GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMTF1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MTF1
dbVarMTF1
ClinVarMTF1
1000_GenomesMTF1 
Exome Variant ServerMTF1
ExAC (Exome Aggregation Consortium)MTF1 (select the gene name)
Genetic variants : HAPMAP4520
Genomic Variants (DGV)MTF1 [DGVbeta]
DECIPHERMTF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMTF1 
Mutations
ICGC Data PortalMTF1 
TCGA Data PortalMTF1 
Broad Tumor PortalMTF1
OASIS PortalMTF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMTF1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMTF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MTF1
DgiDB (Drug Gene Interaction Database)MTF1
DoCM (Curated mutations)MTF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MTF1 (select a term)
intoGenMTF1
Cancer3DMTF1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600172   
Orphanet
MedgenMTF1
Genetic Testing Registry MTF1
NextProtQ14872 [Medical]
TSGene4520
GENETestsMTF1
Target ValidationMTF1
Huge Navigator MTF1 [HugePedia]
snp3D : Map Gene to Disease4520
BioCentury BCIQMTF1
ClinGenMTF1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4520
Chemical/Pharm GKB GenePA31235
Clinical trialMTF1
Miscellaneous
canSAR (ICR)MTF1 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMTF1
EVEXMTF1
GoPubMedMTF1
iHOPMTF1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:20:48 CEST 2017

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